Clinical trials: Glucose Regulation
Bariatric Surgery
The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition
This study is being conducted to evaluate changes in sugar, metabolism, heart function and changes in body composition as patients lose weight following bariatric surgery.
- Trial name
- NCT00686972
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Appetite and General Nutritional Disorders
The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in…
- Trial name
- PROTEIN (NCT04876495)
- Testing
- Whey protein isolate, Potato protein isolate, Rice protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Obesity, Insulin Resistance
Inflammation Regulation in Obese Patients
Insulin resistance is one of the main mechanisms involved in metabolic diseases. inflammation has been implicated in its pathogenesis, due to innate immunity activation by free fatty acids, lipopolysaccharides (LPS) and lactate.
- Trial name
- NCT01561664
- Testing
- muscle and fat biopsy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Postprandial Glucose Regulation
Effect of the Imera Cultivar Carob in Postprandial Glycemia
An acute randomized crossover study on the effect of a carob beverage on postprandial glycemic response
- Trial name
- IMERACAROBGLUC (NCT06906965)
- Testing
- Carob beverage, Sucrose beverage
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Depression, Insulin Resistance
Endogenous Opioid Activity and Affective State in Insulin Resistant Women
Insulin resistance, a primary component of the metabolic syndrome, is an escalating phenomenon in the United States, and confers an increased risk of depression and mood disorder, particularly in women.
- Conditions
- Depression, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT02069379
- Testing
- Metformin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Relapsing Remitting Multiple Sclerosis, Clinically Isolated Syndrome
Clinical Importance of Glucose Regulation in Relapsing MS
The purpose of this study is to assess the relationship of blood glucose levels in persons with Multiple Sclerosis (MS) who have experienced a relapse and will be receiving intravenous steroids for the relapse, to their recovery…
- Trial name
- NCT03004079
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Virginia
Appetite
Metabolic Responses After 12-week Hypocaloric Diet Supplemented With a Cereal-based Plant Protein Biscuit
Biscuits enjoy high popularity in the human diet and can be excellent snack alternatives and potential carriers of ingredients with appetite regulating properties.
- Trial name
- NCT05213559
- Testing
- wheat biscuit enriched with plant proteins, common wheat biscuit
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Appetite Regulation
The Effects of Rye Crisp Bread on Appetite and Metabolic Function
The aim of this study is to contribute to a better understanding of how dietary fibre in rye affects appetite and metabolic processes.
- Trial name
- S2RBAM (NCT02011217)
- Testing
- Rye crisp bread A, Rye crisp bread B, Wheat crisp bread C
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Obesity, Morbid Obesity
Energy Balance and Inflammation in Obese Adults Bariatric Surgery Follow-up
The prevalence of obesity is steadily growing in many parts of the world in order to reach epidemic proportions. Changes in signaling pathways state of hunger and satiety contribute to the increase in obesity and metabolic…
- Conditions
- Obesity, Morbid Obesity, Metabolic Syndrome, Inflammation
- Trial name
- NCT02101814
- Testing
- Roux-en-Y gastric bypass (bariatric surgery)
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Federal University of São Paulo
PreDiabetes
MINDD 3: Prediabetes and Delay Discounting
The proposed research will translate research on delay discounting to the prevention of Type 2 diabetes (T2D) in persons with prediabetes.
- Trial name
- MINDD (NCT03664726)
- Testing
- Episodic Future Thinking, Episodic Recent Thinking, Scarcity Narrative
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Leonard Epstein
Dehydration, Diabetes Mellitus, Type 2
INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers
Previous studies have indicated increased vasopressin due to hypertonic saline infusion impairs glucose regulation. The current study will examine the effect of low water intake on glucose regulation.
- Trial name
- INDIGO-2 (NCT04076995)
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Type-1 Diabetes
Comparison of Closed-loop Operation After Morning Meal With and Without Carbohydrate Counting
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosage based on the sensor's…
- Trial name
- CLASS02 (NCT01519102)
- Testing
- Dual Hormone closed-loop system
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
Obesity
Role of Sweetness in Glucose Regulation
Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of…
- Trial name
- STS (NCT03844230)
- Testing
- Control - Inhibition, Experimental I- Inhibition, Experimental II- Inhibition
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Disorder of Glucose Regulation
SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important…
- Trial name
- SEGATROM (NCT02219295)
- Testing
- sweet block, bitter block, umami-block
- Where
- Germany
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Diabetes Mellitus, Type 2
Pioglitazone Incretin Study
Incretin hormones are hormones produced by the gut in response to food intake. These hormones help the body to control the metabolism of glucose (sugar).
- Trial name
- NCT00656864
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Vermont
Obesity, Diabetes
Endocrine Regulation of Lipolysis in Obesity and Diabetes
Adipose tissue (AT) dysfunction is a commonly observed feature of metabolic dysfunction in obesity and diabetes. An important characteristic when examining AT function is the capacity to break down stored lipids (i.e.
- Trial name
- ERLO (NCT02598544)
- Testing
- adipose tissue sampling
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Shift Work, Eating Behaviors
The Feasibility of Overnight Time Restricted Eating and Impact on Glucose Levels in Shift Workers
The aim of this clinical trial is to assess whether it is feasible for shift workers to follow a time-restricted eating diet. The trial will investigate the impact of time-restricted eating on blood glucose levels during day and…
- Trial name
- TREsh (NCT06686667)
- Testing
- Time Restricted Eating
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Woolcock Institute of Medical Research
Type 2 Diabetes, Insulin Requiring
The Effect of Ethanol on Overnight Glucose Regulation in Type 2
Hypoglycemia is the principal barrier to the achievement of target glycemic goals in type 2 diabetes. Alcohol consumption is very prevalent in our society and a proven cause of hypoglycemia.
- Trial name
- NCT00566592
- Testing
- oral ethanol, overnight, IV ethanol, soda water
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)