Clinical trials: Glucose Regulation
Weight Loss, Obesity
Effects of Negative Energy Balance on Muscle Mass Regulation
The investigators here propose to perform a prospective randomized intervention trial in post-menopausal women to investigate the endocrine network, which contributes to the changes in skeletal muscle mass during weight loss.
- Conditions
- Weight Loss, Obesity, Skeletal Muscle, Insulin Sensitivity/Resistance
- Trial name
- NCT01105143
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Obesity
Sleep and Obesity in Teenagers
This study aims to investigate 1. whether sleep extension results in improvements of endocrine and metabolic markers of obesity and diabetes in obese teenagers, 2.
- Trial name
- NCT00841347
- Testing
- habitual sleep length period + extended sleep length period, extended sleep length period + habitual sleep length period
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Postprandial Blood Glucose, Gut Microbiota
Effect of Fat Quality on Glycemic Regulation and Gut Microbiota After a Short-time Intervention in Healthy Individuals
The overall aim is to investigate effects of saturated versus polyunsaturated fat on glycemic regulation and satiety in a postprandial study with healthy individuals.
- Conditions
- Postprandial Blood Glucose, Gut Microbiota, Satiety
- Trial name
- NCT03658681
- Testing
- Saturated fat 14.9 E%, Polyunsaturated fat 13.6 E%
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Obesity, Diabetes Mellitus, Type 2
Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia, appetite, plasma amino acid concentrations, and gastrointestinal hormones…
- Trial name
- NCT05919667
- Testing
- Dairy and plant-based dairy beverages and solids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes
Regulation of Hepatic Insulin Extraction
This study is in the area of Type 2 diabetes and genetics Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate This study is searching for genes that may affect the body's processing/digestion of…
- Trial name
- RHIE (NCT00811044)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Adult
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and…
- Trial name
- NCT07361406
- Testing
- Diet with non-nutritive sweeteners, Diet without non-nutritive sweeteners
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Obesity, Prader Willi Syndrome
Macronutrient Regulation of Ghrelin and Peptide YY
The hyperghrelinemia of children with PWS provides a unique model by which to explore the hormonal and metabolic effects of orexigenic hormones in normal and pathologic conditions.
- Trial name
- NCT02464514
- Testing
- High carbohydrate meal, High fat meal
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Insulin Resistance Syndrome
Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
There is currently no reliable, diagnostic tests of insulin resistance other than the hyperinsulinemic euglycemic clamp which, due to its constraints and cost, is reserved for research.
- Trial name
- IRAP-IR (NCT04028895)
- Testing
- Dosage of IRAP during OGTT
- Where
- 4 sites in France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Overweight and Obesity
Lifestyle Intervention for Patients With Impaired Glucose Regulation
Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs.
- Trial name
- NCT04469400
- Testing
- Low fat diet intensive intervention, Low-Carbon Water Diet Intensive Intervention
- Where
- 8 sites in China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Type 2 Diabetes, Glucose Metabolism Disorders
The CGM-OGTT Glycemic Homeostasis Study
This is a prospective, exploratory, observational study aimed at investigating the mechanisms of glycemic homeostasis by comparing continuous glucose monitoring (CGM) data with results from the oral glucose tolerance test (OGTT).
- Trial name
- NCT07288372
- Volunteers
- 225 people
- Sponsor
- Shanghai 6th People's Hospital
Type2 Diabetes, Cardiovascular Diseases
Peanuts and Glycemic Control
A two-period randomized crossover study will be conducted to determine the effect of peanuts on glycemic control, and elucidate the role of the microbiome in glucose regulation, in individuals with impaired fasting glucose.
- Trial name
- NCT03654651
- Testing
- Peanut, High carbohydrate snack
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Penn State University
Diabete Type 2, Obesity
Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables
The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT05276128
- Testing
- lipids
- Where
- 2 sites in Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Metabolic Syndrome, Pre-Diabetes
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome
In a randomized controlled trial, the investigators intend to measure the health impact of TRE in patients with metabolic syndrome (with three or more of the following criteria: increased waist circumference, abnormal cholesterol…
- Trial name
- TIMET (NCT04057339)
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, San Diego
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM)
Research on Gut Microbiota and Metabolomics in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by high prevalence, multiple pathogenesis, and lack of effective treatment and management strategies.
- Conditions
- Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- NCT06833541
- Where
- China
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Type 1 Diabetes
Technology-delivered Physical Activity Program for Adolescents With Type 1 Diabetes
This project is comprised of a two-arm randomized control trial (RCT) testing the feasibility, acceptability, and preliminary efficacy of a nationally scalable program, Activate, a 12-week, technology-delivered diabetes…
- Trial name
- Activate (NCT05319600)
- Testing
- Diabetes behavior change skills training, Physical activity promotion program
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Obesity
Effect of Flaxseed on Lipid Uptake and Appetite
Randomized trial to test the effect of flaxseed fractions on appetite regulation and intestinal lipid absorption.
- Trial name
- NCT00465036
- Testing
- Whole flaxseeds, flaxseed mucilage, glucomannan
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypertriglyceridaemia
Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Sugars on Liver Fat Metabolism
High levels of fatty substances in the blood increase the risk of developing coronary heart disease and having a heart attack. The investigators know a lot about one of these fatty substances, cholesterol.
- Trial name
- NCT02478541
- Testing
- Sugar study
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Dietary Prevention
Effects of Legumes on Glucose Regulation
Dietary prevention strategies are increasingly recognized as essential to combat the current epidemic of obesity and related metabolic disorders.
- Trial name
- NCT01706042
- Testing
- legume meal, white bread
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lund University
Hyperglycemias, Prediabetes
Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With Hyperglycemia
This study will evaluate the effects of pA1c®HI, a heat-inactivated postbiotic derived from the bacterium Pediococcus acidilactici, on blood glucose regulation and other aspects of metabolic health in adults with elevated blood…
- Trial name
- CR2027 (NCT07903870)
- Testing
- Postbiotic
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genbioma Aplicaciones SL
Diabetes Mellitus, Type 1
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
Glutathione is normally present at high levels in the blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by several reactive oxygen species produced by…
- Trial name
- NCT00858273
- Testing
- Antioxidant supplement, Diabetes treatment, Regular Insulin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Nemours Children's Clinic