Clinical trials: Glucose Regulation
Blood Glucose, Low, Hunger
Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake
The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose…
- Trial name
- NCT04991714
- Testing
- Lactisole, Rebaudioside M, Sucrose
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Insulin Resistance
IRAPs (Secreted Insulin Regulated AminoPeptidase): a New Insulin Sensitivity Biomarker
Previous studies have demonstrated defects in the trafficking and translocation of GLUT4 glucose transporter in skeletal muscle and adipose tissue to be a major cause of insulin resistance in humans.
- Trial name
- IRAP (NCT01648478)
- Testing
- It is a hyperinsulinemic-euglycemic clamp.
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Serious Games, Psychological Flow
Flow Regulation in Medical Serious Games
The goal of this study is to access the effect of facilitation on amount of psychological Flow generated in medical students playing a medical serious game.
- Conditions
- Serious Games, Psychological Flow, Diabetes Mellitus
- Trial name
- NCT05637749
- Testing
- Medical serious game intervention (educational)
- Where
- Singapore
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Diabetes Mellitus, Type 2
SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.
The aim of this study is to investigate the cause for the discrepancy in predicted and observed weight loss with Empagliflozin (Jardiance™) by measuring appetite regulation.
- Trial name
- SEESAW (NCT02798744)
- Testing
- Empagliflozin, Diet
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Leicester
Obesity, Diabetes
Fibre and Appetite Regulation Trial (FART)
High intake of cereal fibre has been shown to be associated with reduced weight gain and improved insulin sensitivity. We hypothesize these effects are due to the short chain fatty acids derived from the bacterial fermentation…
- Trial name
- NCT00247455
- Testing
- Low fibre breakfast cereal (puffed rice/cornflakes), High fibre cereal (All Bran/Bran Flakes)
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 1 Diabetes
Pancreatic Enzyme Replacement and Glucose Regulation in Type 1 Diabetes
Recent studies have demonstrated reduced pancreatic volume is present within months of T1D diagnosis in children, adolescents, and adults.
- Trial name
- CREON (NCT05266963)
- Testing
- CREON
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes, Cardiometabolic Syndrome
PDE3B in Metabolic Regulation
Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes.
- Conditions
- Type 2 Diabetes, Cardiometabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT06533007
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Overweight and Obesity
Lifestyle Intervention for Patients With Impaired Glucose Regulation
Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs.
- Trial name
- NCT04469400
- Testing
- Low fat diet intensive intervention, Low-Carbon Water Diet Intensive Intervention
- Where
- 8 sites in China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pre-diabetes
High Protein Diet on Transcriptomic, Metabolomics, Hepatic and Pancreatic Fat Anatomy and Physiology in Asian Indians With Pre-diabetes
Diabetes/ prediabetes is a substantial problem in India not only because it itself can be associated with morbidities such as coronary artery disease but also because it is a point of importance for the prevention of other…
- Trial name
- NCT05925933
- Testing
- Intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Post Bariatricsurgery, Hypoglycemia
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
RYGB (roux-en-y gastric bypass) has been reported to reverse type 2 diabetes (T2DM) immediately after surgery before any significant weight loss.
- Trial name
- NCT00992901
- Testing
- Exendin-(9-39), Atropine, GLP-1 and GIP
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Stroke, Hyperglycemia
Glucose Regulation in Acute Stroke Patients (GRASP) Study
The purpose of this study is to assess the feasibility, safety and preliminary efficacy of the use of insulin infusions as treatment for hyperglycemic acute ischemic stroke patients.
- Trial name
- NCT00282867
- Testing
- IV glucose insulin and potassium, GIK, standard care
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of Virginia
Hyperglycemia, Critical Illness
Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)
The primary aim of the study is to compare the effects of the two blood glucose targets on 90 day all-cause mortality in Intensive Care patients who are predicted on admission to stay in the ICU for at least one full calendar…
- Trial name
- NCT00220987
- Testing
- Intensive Insulin Therapy, Conventional Insulin therapy
- Where
- Australia
- Volunteers
- 6,104 people
- Sponsor
- The George Institute
Diabetes Mellitus, Type 2
Effects of Nurse-Led Diabetes Education and Telephone Follow-Up in Newly Diagnosed Type 2 Diabetes
This randomized controlled trial evaluated the effects of nurse-led diabetes self-management education supported by telephone follow-up on diabetes knowledge, self-management behaviors, and glycemic control in adults newly…
- Trial name
- NCT06963073
- Testing
- Nurse-Led Diabetes Self-Management Education and Telephone Follow-Up
- Where
- Cyprus
- Volunteers
- 60 people
- Sponsor
- Naile ALANKAYA
Healthy Volunteers
Marine Protein Hydrolysate as Dietary Supplement in Elderly Part I
The aim of this study is to investigate the potential effect of a marine protein hydrolysate (MPH) supplement before a meal on postprandial glucose tolerance in healthy subjects, to achieve more knowledge on this presumed…
- Trial name
- MPH-BS (NCT03669796)
- Testing
- Marine protein hydrolysate (mph), Control
- Where
- 2 sites in Norway
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Helse Møre og Romsdal HF
Diabetes
The Effect of Wild Blueberry Consumption on Glucose Regulation in Healthy Adults
The objective of the study is to determine how wild blueberry consumption affects glucose regulation, gastrointestinal hormones and satiety in healthy adults.
- Trial name
- NCT03192605
- Testing
- Blueberry
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma
Monitoring and Managing Glucose Levels in People With Pancreatic Cancer
This study will investigate the prevalence of hyperglycemia (high blood sugar) in approximately 50 participants with pancreatic cancer.
- Conditions
- Pancreatic Cancer, PDAC - Pancreatic Ductal Adenocarcinoma, Hyperglycemia
- Trial name
- PEGASUS (NCT05132244)
- Testing
- Glucose Measurements via Blood Draw
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Polycystic Ovary Syndrome
Development of a Structured Education Programme for Women With Polycystic Ovary Syndrome
Polycystic Ovary syndrome (PCOS) is a common hormonal imbalance affecting about 12% of women in the UK. The number of women with PCOS is rising.
- Trial name
- SUCCESS (NCT01462864)
- Testing
- Structured Lifestyle Education
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University of Leicester
Diabetes Mellitus, Impaired Glucose Tolerance
Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial)
The objective of this trial is to investigate the effect of early treatment of glucose toxicity with acarbose, a drug to control postprandial hyperglycemia, on the occurence of cardiovascular events and the inhibition of…
- Conditions
- Diabetes Mellitus, Impaired Glucose Tolerance, Coronary Artery Disease
- Trial name
- NCT00858676
- Testing
- acarbose
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Aichi Gakuin University
Markers of Inflammation, Hyperglycemia, Postprandial
Effect of Hibiscus Sabdariffa Beverage
There are numerous plant foods that are a source of bioactive compounds, which can induce an anti-inflammatory effect on various pathways of inflammatory processes in the body as it may be useful in decreasing markers of…
- Conditions
- Markers of Inflammation, Hyperglycemia, Postprandial, Hyperinsulinism
- Trial name
- Hibiscus (NCT05774613)
- Testing
- Effect of a Hibiscus sabdariffa beverage
- Where
- Mexico
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnológico y de Estudios Superiores de Occidente
Diabetes Prevention, Obesity Prevention
Fluid Dairy Products Consumed Before and Within a Pizza Meal on Glycemic Response, Food Intake and Satiety in Children
The purpose of this study is to examine the effects of fluid dairy products on blood glucose and insulin, satiety and energy intake in normal weight and overweight/obese children in the age range of 9-14 y.
- Trial name
- NCT02147496
- Testing
- Dietary Intervention
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Toronto