Clinical trials: Glucose Regulation
Type 2 Diabetes Mellitus
Insulin Receptor Substrate 1 (IRS-1) Regulation in Insulin Resistance
The study is being conducted to find out why too much fat in your blood stream may cause insulin resistance in your muscles. Insulin is the hormone, produced normally by your body, which causes your blood sugar to return to…
- Trial name
- NCT01240252
- Testing
- Human insulin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Food Intake Regulation, Substrate Oxidation
Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men
The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.
- Trial name
- NCT01888991
- Testing
- Glucose Preload and Exercise Intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Myocardial Ischemia, Autonomic Neuropathy
Coronary Blood Flow Regulation During General Anesthesia
The central hypothesis in the present project is that general anesthesia may alter autonomic control such that perioperative coronary blood flow (CBF) is significantly disturbed.
- Conditions
- Myocardial Ischemia, Autonomic Neuropathy, Healthy, Diabetes
- Trial name
- NCT00866801
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Metabolic Syndrome X, Type 2 Diabetes Mellitus
Effect of Fish Oil on Insulin Sensitivity
The purpose of this study is to determine whether a prolonged (9 month) high (6g/d) of marine oil improves insulin sensitivity and glucose control in subjects with impaired glucose regulation.
- Conditions
- Metabolic Syndrome X, Type 2 Diabetes Mellitus, Sarcopenia
- Trial name
- NCT01241474
- Testing
- EPAX 6000 (marine omega 3 EPA/DHA fatty acid concentrates, Maize (corn) oil
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Aberdeen
Appetite
Cereal-based Products Fortified With Legumes and Effects on Glycemic Control and Appetite Regulation
Legumes are rich source of proteins and dietary fibers which are associated with satiety and amelioration of postprandial glycemic response.
- Trial name
- NCT03974165
- Testing
- Cereal-legume product 1, Cereal-legume product 2, Cereal product
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482675
- Testing
- Glucose, Glucose with Non-fat Milk, Glucose with Whey Protein Isolate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Type 1 Diabetes
Ultrarapid Insulin Administered by a Bihormonal Closed Loop System in Patients With Type 1 Diabetes
The main objective is to determine the efficacy of Lyumjev (insulin) in a bi-hormonal reactive closed loop system for automated glucose regulation (artificial pancreas; AP®) in patients with diabetes mellitus type 1.
- Trial name
- FAST 1 (NCT05508061)
- Testing
- Insulin Lispro Cartridge [Lyumjev], Insulin Lispro Cartridge
- Where
- 3 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- Inreda Diabetic B.V.
Nonalcoholic Fatty Liver Disease
Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease
The purpose of this study is to evaluate the effects and safety of pioglitazone and berberine on the basis of lifestyle intervention to non-alcoholic fatty liver disease patients with impaired glucose regulation or type 2…
- Trial name
- NCT00633282
- Testing
- Life style intervention, pioglitazone, berberine
- Where
- 3 sites in China
- Volunteers
- 184 people
- Sponsor
- Xin Gao
Inflammation, Glucose Regulation
Tart Cherry Supplementation & Gut Microbiome and Inflammation
There has been a rapid increase in researching the use of tart cherry supplements in the past 5 years, particularly for inflammatory conditions.
- Conditions
- Inflammation, Glucose Regulation, Sleep
- Trial name
- NCT04467372
- Testing
- Tart cherry juice concentrate, Freeze dried tart cherry powder
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio University
Glucose Regulation, Low-grade Inflammation
Effect of Milk Ingredients on Glucose Regulation and Inflammation
Background: Recent advances in science have established a fundamental role for low grade chronic inflammation in mediating all stages of most of the non-communicable diseases associated with ageing.
- Trial name
- NCT02011672
- Testing
- nutrient-enriched milk, regular milk
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Diabetes
Diabetes Management Personal Trainer
This 1-year study will test the feasibility and effectiveness of a diabetes personal trainer in helping youth with diabetes manage their treatment.
- Trial name
- NCT00340093
- Testing
- Managing Diabetes
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NAFLD, Overweight and Obesity
The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content
The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.
- Conditions
- NAFLD, Overweight and Obesity, Metabolic Syndrome, Diabetes
- Trial name
- LICARB (NCT04581421)
- Testing
- High Carb Low Fat Diet, Low Carb High Fat Diet
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Insulin Resistance
Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin
The purpose of this study is to learn more about how insulin resistance (inability to process glucose correctly resulting in mildly elevated glucose levels) affects the hormone ghrelin.
- Trial name
- NCT00843791
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Schizophrenia, Type 2 Diabetes Mellitus
Pfizer/IVGTT/Ziprasidone/Olanzapine
Abnormalities in peripheral glucose regulation and type 2 diabetes can occur more commonly in individuals with schizophrenia than in healthy subjects or in other psychiatric conditions.
- Trial name
- NCT00205725
- Testing
- Ziprasidone, Olanzapine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Blood Sugar (Glucose) Control, Postprandial Glucose
Effect of SugarLock® Peanut Skin Extract on Postprandial Blood Glucose Control
The objective of this study is to investigate the effects of pre-meal supplementation with SugarLock® peanut skin extract and white kidney bean extract on reducing or delaying postprandial blood glucose elevation and glycemic…
- Trial name
- NCT07705191
- Testing
- Peanut skin extract, White kidney bean extract, Water
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Healthy
CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men
The original purpose of this research study was to understand the effects of testosterone (T) and estrogen on stem cells in the blood.
- Trial name
- CEP-1 (NCT00729859)
- Testing
- Acyline, Acyline + Testosterone gel, Acyline + testosterone gel + anastrozole
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Washington
Aging, Insulin Sensitivity
Antecedent Metabolic Health and Metformin Aging Study
Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan.
- Conditions
- Aging, Insulin Sensitivity, Chronic Disease, Mitochondria
- Trial name
- ANTHEM (NCT04264897)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Type 1 Diabetes Mellitus
Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas
BACKGROUND. Optimal glucose control can prevent/relent tissue damage in patients with type 1 diabetes mellitus (T1DM). Ongoing efforts aim at developing closed loop control (CLC) algorithms linking subcutaneous continuous glucose…
- Trial name
- NCT02003274
- Testing
- Clamp-Mixed Meal, IVGTT-Mixed Meal Arm
- Where
- 2 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Blood Glucose, Energy Intake
The Effect of Snacks on Glycaemic Regulation in Children
Dairy products have a potential to be healthy snack foods for children. The purpose of this project is to investigate the short-term effects of Greek yogurt, a new popular dairy product on the regulation of glucose homeostasis…
- Trial name
- NCT02484313
- Testing
- dietary treatments
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mount Saint Vincent University