Clinical trials: Glucose Regulation
Hypertriglyceridaemia
Understanding Liver Fat Metabolism: Studies to Understand the Role of Dietary Sugars on Liver Fat Metabolism
High levels of fatty substances in the blood increase the risk of developing coronary heart disease and having a heart attack. The investigators know a lot about one of these fatty substances, cholesterol.
- Trial name
- NCT02478541
- Testing
- Sugar study
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Type 2 Diabetes
SIT LESS 2: Effect of Sitting Less on Glucose Regulation in People With Diabetes Mellitus Type 2
Introduction: Changes in lifestyle are responsible for an important part of the type 2 diabetes epidemic of the last decennia. Current guidelines for physical activity focus mainly on high energy expenditure advising 30 minutes…
- Trial name
- SIT LESS 2 (NCT02371239)
- Testing
- Physical activity intervention
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus Nos New Onset, Hypertrophy, Left Ventricular
New-onset Diabetes and Left Ventricular Hypertrophy in Renal Transplantation
New-onset diabetes (NODAT) after solid organ transplantation is an important clinical challenge associated to increased risk of cardiovascular (CV) events.
- Conditions
- Diabetes Mellitus Nos New Onset, Hypertrophy, Left Ventricular, Vascular Stiffness
- Trial name
- NCT01976689
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Baskent University
Substrate Absorption, Substrate Oxidation
Effect of Lactose, Fructose, Sucrose, Whey Protein, and Soy Protein on Substrate Absorption and Oxidation: a Pilot Study
Does the consumption of various combinations of mono and disaccharides (lactose, sucrose and fructose) and protein isolates (whey or soy) result in altered substrate absorption, substrate oxidation, and glucose regulation? This…
- Conditions
- Substrate Absorption, Substrate Oxidation, Glucose Regulation
- Trial name
- NCT00942513
- Testing
- trt 1, trt 2, trt 3
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Hypoglycemia Unawareness, Diabetes Mellitus, Type 1
Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
This is a prospective, randomized, controlled, double-blind, parallel 4-group trial with the primary analysis after 4 weeks of treatment with continuous subcutaneous glucagon infusion (CSGI) or placebo.
- Trial name
- NCT03490942
- Testing
- Glucagon
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- Xeris Pharmaceuticals
Diabetes
Walking Away: Structured Education Versus Written Information for Individuals With High Risk of Developing Type 2 Diabetes
Diabetes is a debilitating chronic disease reaching epidemic proportions. Lack of physical activity is a key factor driving this epidemic and it is therefore vital that workable methods of encouraging people to exercise and…
- Trial name
- NCT00941954
- Testing
- Structured Education, Written Information
- Where
- United Kingdom
- Volunteers
- 833 people
- Sponsor
- University Hospitals, Leicester
Type 2 Diabetes
Effect of Rosiglitazone on Myocardial Blood Flow Regulation in Type 2 Diabetes
The overall hypothesis to be tested is that increased insulin resistance contributes to abnormal cardiac blood flow regulation in type 2 diabetic patients, which can be reversed by 6 months treatment with rosiglitazone.
- Trial name
- NCT00549874
- Testing
- Rosiglitazone, Glyburide
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Michigan
Overweight and Obesity
Effects of Oral vs Intravenous Glucose Administration on Novel Candidates of Energy Regulation
Energy regulation in humans is controlled through complicated mechanisms involving among others hormones secreted from different tissues, such as gut, muscle and adipose tissue.
- Trial name
- NCT04888325
- Testing
- Oral glucose, Intravenous glucose
- Where
- Greece
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Type 2
The Effect of Esomeprazole on Type 2 Diabetes
The investigators aimed to prospectively investigate the effects of esomeprazole on glycaemic control in patients with type 2 diabetes mellitus. The investigators also aimed to associate this effect with gastrin levels.
- Trial name
- NCT03598738
- Testing
- Esomeprazole 40mg
- Volunteers
- 32 people
- Sponsor
- Baskent University Ankara Hospital
Postprandial Glucose Regulation
Health Effects of Oat and Oat Bioactive in Human
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods
- Trial name
- NCT04542265
- Testing
- Effects of Oat and Oat Components on Cardiometabolic risk variables
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Glucose Tolerance, Appetite Sensations
Effects of Nopal Fractions on Postprandial Glucose Regulation and Appetite Variables in Healthy Humans
Postprandial effects of Nopal fractions on glucose and appetite regulation will be investigated in healthy humans, in a randomised controlled crossover trial
- Trial name
- NCT04439630
- Testing
- Nopal fractions, Test product without the active components
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 1 Diabetes (T1D)
The T1D Talks Pilot Study
Despite recent technological advances in type 1 diabetes (T1D) treatment, adolescents are the only age group for which glycemic levels have not improved.
- Trial name
- NCT07109128
- Testing
- The T1D Talks: A Virtual Group for Teens and Tweens with T1D
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Western Michigan University School of Medicine
Type 2 Diabetes Mellitus
The Effects of Soy Isoflavones to Improve the Metabolism of Glucose and Lipids
Many studies showed that soy foods or soy isoflavones can lower the risk of cardiovascular disease (CVD), osteoporosis and some cancers, but few human studies assessed effects of purified isoflavone components (genistein and…
- Trial name
- NCT00951912
- Testing
- Daidzein, Genistein
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Sun Yat-sen University
Diabetic Peripheral Neuropathy, Balance
Effects of Virtual Reality-Based Balance Training Compared to Conventional Balance Training to Reduce Risk of Fall in Patients With Diabetic Peripheral Neuropathy: A Randomized Control Trial
The objective of this study is to determine the effects of virtual reality based balance training compared to conventional balance training to reduce risk of fall in patients with diabetic peripheral neuropathy in terms of fall…
- Conditions
- Diabetic Peripheral Neuropathy, Balance, Fall Risk
- Trial name
- NCT06740227
- Testing
- Virtual Reality-Based Balance Training, Conventional Balance Training
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Insulin Sensitivity, Multiple Mitochondrial Dysfunctions Syndrome
Study of Dapagliflozin on Mitochondrial Dysfunction and Impaired Insulin Signaling/Action
The purpose of this study is to examine the effect of the chronic treatment of type 2 diabetes (T2DM) with dapagliflozin on: (1) mitochondrial gene function/expression and insulin signaling/action and (2) oral glucose tolerance…
- Trial name
- DAPA MITO (NCT01439854)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Glucose Intolerance
Effects of Two Doses of Thylakoids on OGTT
This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy…
- Trial name
- NCT02702245
- Testing
- Experimental: Thylakoids 5 g, Experimental: Thylakoids 10 g
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Region Skane
Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb
The Impact of Sexual Health and Amputation Focused Education on Regulation of Glucose and Amputation Prevention
The purpose of this study is to investigate the effect of two types of education on HbA1c level and future amputations in inpatient diabetics after initial minor foot amputation
- Conditions
- Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb, Sexual Dysfunction, Diabetic Foot Ulcer Ischemic
- Trial name
- NCT04078854
- Testing
- Diabetes education
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Montefiore Medical Center
Type 2 Diabetes, Impaired Insulin Secretion
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans
Insulin resistance and the depletion of insulin secretion are major pathogenetic aspects of type 2 diabetes mellitus. Recently, inceptor, a receptor on the surface of beta cells was dicovered.
- Trial name
- NCT05575206
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes, Impaired Glucose Regulation
Plasma Transthyretin Levels and Risk of Type 2 Diabetes Mellitus and Impaired Glucose Regulation
Objective: To investigate the association between plasma transthyretin levels and risk of newly diagnosed type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR) in a Chinese population.
- Trial name
- NCT05370560
- Testing
- Plasma transthyretin concentration
- Volunteers
- 3,325 people, healthy volunteers welcome
- Sponsor
- Liegang Liu