Clinical trials: Glucose Regulation
Growth Hormone Deficiency
Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates
Study hypothesis: Growth hormone (GH), through its generation of free 'bioavailable' insulin-like growth factor (IGF)-I, can improve insulin sensitivity in adults with GH deficiency.
- Trial name
- NCT00517062
- Testing
- Growth hormone (Genotropin)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Weight Loss, Obesity
Effects of Negative Energy Balance on Muscle Mass Regulation
The investigators here propose to perform a prospective randomized intervention trial in post-menopausal women to investigate the endocrine network, which contributes to the changes in skeletal muscle mass during weight loss.
- Conditions
- Weight Loss, Obesity, Skeletal Muscle, Insulin Sensitivity/Resistance
- Trial name
- NCT01105143
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 2
Efficacy of Educational Nutrition and Exercise on the Regulation of Appetite Through Exosomes in Type 2 Diabetics
The aim of this randomized controlled trial is to investigate the effects of different aerobic modalities: moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), and a nutritional intervention…
- Trial name
- APETEX (NCT05259449)
- Testing
- Nutritional Intervention, High-intensity interval training (HIIT), Moderate-intensity continuous training (MICT)
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- University of Cadiz
Obesity, Healthy
Meal-regulated Substrate Metabolism, Influence of Obesity and IL-6
The overall purpose of this explorative yet quantitative study project is to understand how blocking IL-6 signaling leads to the expansion of adipose tissue mass in humans in vivo.
- Trial name
- NCT04687540
- Testing
- Tocilizumab, Saline 0.9%
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetes Mellitus, Heart Failure
Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment
The purpose of this study is to investigate the effects of Dapagliflozin (FORXIGA) 10mg (n=20) and placebo (n=20) on the renal concentration mechanism, mobilization of Na+ from tissue stores, and mobilization of muscle glycogen…
- Trial name
- DAPA-Shuttle1 (NCT04080518)
- Testing
- Dapagliflozin 10 MG [Forxiga]
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National Heart Centre Singapore
Type 2 Diabetes, Binge Eating
Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes
The purpose of this 6-month randomized clinical trial is to examine the feasibility of recruitment, attendance, retention, program adherence, and satisfaction of a digital application designed, Centering Appetite to improve…
- Trial name
- NCT05741125
- Testing
- DSME + ASE intervention (Centering Appetite)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gestational Diabetes, Pregnancy Related
Glycemic Observation and Metabolic Outcomes in Mothers and Offspring
The overarching goal of Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs) is to perform a comprehensive, longitudinal description of maternal glycemia over the course of pregnancy and to evaluate how…
- Trial name
- GO MOMs (NCT04860336)
- Testing
- Observational
- Where
- 9 sites in United States
- Volunteers
- 2,179 people
- Sponsor
- Northwestern University
Fetal Macrosomia, Gestational Diabetes
Regulation Of Maternal Fuel Supply And Neonatal Adiposity
The purpose of this study is to determine whether unrecognized maternal hyperglycemia and postprandial lipemia early or late in gestation predicts excess neonatal adiposity.
- Trial name
- NCT00826904
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Disease
Identifying the Effect and Working Mechanisms of MyPlan 2.0 in Adults With Type 2 Diabetes
The aim of this study is to investigate whether and how 'MyPlan 2.0' helps adults with type 2 diabetes to be more physically active or less sedentary.
- Trial name
- NCT03291171
- Testing
- MyPlan 2.0
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University Ghent
Healthy Adult
SweetSpot - The Effect of Non-nutritive Sweeteners on Health
The aim of the study is to investigate the effect of non-nutritive sweeteners on glucose regulation. Secondary objectives are to investigate the effect of NNS on gut microbiome, gut hormone secretion, sweet taste sensitivity and…
- Trial name
- NCT07361406
- Testing
- Diet with non-nutritive sweeteners, Diet without non-nutritive sweeteners
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Type II Diabetes
Evaluation of Effects of Dibifree® on Regulation of Blood Sugar and HbA1c in Patients With Type II Diabetes
At present, diabetic patients mainly use drugs to control blood sugar. However, drugs have side effects and the control effect varies among individuals.
- Trial name
- NCT06224803
- Testing
- Compound plant extracts, Indigestible dextrin
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Global Preventive Medicine Biotech Co., Ltd.
Aging, Healthy, Blood Sugar; High
Circadian Health Regulation and Optimization for Rejuvenation Outcomes
In this single arm intervention trial, the investigators will assess the impact of a personalized lifestyle plan, centered on supporting biological rhythms, on blood sugar levels, physical, cognitive and immune function in older…
- Conditions
- Aging, Healthy, Blood Sugar; High, Blood Sugar (Glucose) Control, Time Restricted Eating
- Trial name
- CHRONO (NCT07203196)
- Testing
- Circadian Rhythm Optimization
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Salk Institute for Biological Studies
Diabetes Mellitus, Type 2
Incidence of Type 2 Diabetes in the di@Bet.es Study
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population.
- Trial name
- NCT02542735
- Where
- Spain
- Volunteers
- 2,408 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Physiology - Regulation of Appetite and Food Intake
Neurotensin - an Important Regulator of Appetite in Humans?
Neurotensin (NT) is a gut peptide released postprandially from the small intestine. It is known to exert a range of enterogastrone effects and in animal models it reduces food intake when administered by parenteral routes.
- Trial name
- NIRAH (NCT03522792)
- Testing
- Neurotensin, Saline, Ad libitum meal
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Blood Glucose Fluctuations, Hunger
Impact Hesperetin in Combination with Sucrose on Blood Glucose Regulation
The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only…
- Trial name
- NCT06340087
- Testing
- 10% Sucrose, Sucrose+ Hesperetin, 7% Sucrose
- Where
- Austria
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Vienna
PreDiabetes, Appetitive Behavior
Prediabetes, Exercise, and Appetite Regulation
The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.
- Trial name
- PEAR (NCT04910763)
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetes Mellitus, Type 2
Experimental Studies of the Effects of Caffeine on Glucose Regulation
This project contains experimental studies of the effects of the drug caffeine on glucose regulation in adults who have Type 2 diabetes.
- Trial name
- NCT00432887
- Testing
- caffeine administration
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
FAMS-T1D Self-Regulation and Social Support for T1D
The goal of this clinical trial is to evaluate how effective the FAMS-T1D intervention is for improving self-regulation (e.g., setting and meeting goals for type 1 diabetes) and social support for meeting those goals for young…
- Trial name
- FAMS-T1D (NCT05820477)
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Utah