Clinical trials: Glucose Regulation
Overweight, Weight Loss
Study to Evaluate Benefit of ProbioSatys™ on Weight Reduction in Overweight Subjects
The study aims to evaluate the effects of ProbioSatys™ on body weight and related parameters in overweight subjects during a 12-week consumption period. In addition, tolerability and safety of ProbioSatys™ will be assessed.
- Trial name
- NCT03657186
- Testing
- ProbioSatys™
- Where
- 3 sites in Germany
- Volunteers
- 236 people
- Sponsor
- TargEDys
Diabetes
Nutritional Regulation of Wound Inflammation: Part II
Fermented Papaya Preparation (FPP) is a sweet and granular substance available over the counter. FPP possesses antioxidant properties, which provide benefit against age-related complications, and is also known to protect red…
- Trial name
- FPPT2DM-II (NCT01618045)
- Testing
- Fermented Papaya Preparation (FPP)
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Ohio State University
Insulin Resistance
Determining of Normal Values and Conformity Assessment of the Dosage of a Plasmatic Marker of the Cellular Captation of Glucose: the IRAP Protein
The purpose of this study is on one hand to verify the measurement conformity of the IRAP dosage and on the other hand to obtain normal values of the blood IRAP concentration on healthy volunteers.
- Trial name
- IRAP (NCT02941874)
- Testing
- Blood sample collection during an OGTT to assess IRAP blood concentration
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Obesity
A Comparison of the Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Aged 20-60 Years Old
The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.
- Trial name
- NCT01797042
- Testing
- Dietary Compliance
- Where
- United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Rippe Lifestyle Institute
Polycystic Ovary Syndrome, Overweight and Obesity
Research of Exenatide for Overweight/Obese PCOS Patients With IGR
Compare the therapeutic effects of exenatide, metformin and their combination for 3 months on reproductive and metabolic improvements of overweight/obese PCOS patients with impaired glucose regulation.
- Conditions
- Polycystic Ovary Syndrome, Overweight and Obesity, Disorder of Glucose Regulation
- Trial name
- NCT03352869
- Testing
- Exenatide, Metformin
- Where
- China
- Volunteers
- 183 people
- Sponsor
- RenJi Hospital
Impaired Glucose Tolerance
Mechanisms Underlying the Regulation of Impaired Glucose Tolerance by Auricular Concha Electro-acupuncture
Impaired Glucose Tolerance (IGT) is an abnormal metabolic state following glucose metabolic steady state but prior to diabetes. IGT is an important stage during the progression of diabetes, with an underlying mechanism of insulin…
- Trial name
- NCT03343262
- Testing
- ta-VNS, Electro-acupuncture
- Volunteers
- 158 people
- Sponsor
- China Academy of Chinese Medical Sciences
Diabetes Mellitus, Type 1
Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus
Processed carbohydrates cause rapid changes in blood sugar and have been associated with overeating and obesity. We have shown that test meals high in processed carbohydrate affect brain areas involved in addiction, craving and…
- Trial name
- NCT02772783
- Testing
- high GI meal, low GI meal, euglycemic insulin clamp
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Gestational Diabetes Mellitus in Pregnancy
Decreased Insulin Regulated Aminopeptidase (IRAP) Levels in Gestational Diabetes Mellitus
This cohort study investigated whether IRAP levels could be a marker for predicting gestational diabetes mellitus. 80 women were included in the study, including the control group.
- Trial name
- (IRAP) (NCT06716320)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- OSMAN KÖSE, MD
PreDiabetes
Is Teaching People to be Self-compassionate Feasible and Acceptable for People Who Are Pre-diabetic
The investigators plan to examine the feasibility and acceptability of an online, two arm intervention ([self-compassion intervention + ideal care] versus [health information + ideal care]) designed to increase physical activity…
- Trial name
- NCT04402710
- Testing
- Self-compassion, Control Group
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Positive Regulation of Oxidative Stress Process
A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus
This study was performed to assess the efficacy of systemic lycopene (8 mgms Daily for two months) as an adjunct to scaling and root planing in chronic periodontitis patients with type 2 diabetes mellitus.
- Trial name
- "SLSRPD" (NCT02263352)
- Testing
- Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day, Scaling and root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
PreDiabetes
Examining the Impact of a Self-compassion Intervention on Physical Activity Behaviour Among People With Prediabetes
The investigators plan to examine whether teaching people at risk for type two diabetes to use self-compassion (orientation to care for oneself during difficult situations) helps them self-manage and increase their physical…
- Trial name
- NCT04863235
- Testing
- Control Group, Intervention Group
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Impaired Glucose Tolerance
Breaks in Sedentary Time and Glucose Regulation in Women
The number of people diagnosed with Type 2 diabetes (T2DM) is increasing rapidly and about 2.9 million people in the UK currently have diabetes.
- Trial name
- ACUTE (NCT02135172)
- Testing
- Sitting, Standing, Walking
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Leicester
Healthy Subjects
On the Impact of Common Sweetening Agents on Glucose Regulation, Cognitive Functioning and Gut Microbiota
The study intention is to investigate, in healthy humans, effects of 3 commonly used sweeteners on cardiometabolic risk markers, cognitive functions, and influences on gut microbiota composition.
- Trial name
- NCT02580110
- Testing
- Sucrose, Stevia glycosides, saccharin
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Lund University
Fatty Liver Disease, Type 2 Diabetes
Effect of Intermittent Calorie Restriction on MASLD Patients With Abnormal Glucose Metabolism
This study is designed to observe the effect of 5:2 intermittent calorie restriction (fasting 2 days each week) on liver fat content in MASLD patients with abnormal blood glucose.
- Conditions
- Fatty Liver Disease, Type 2 Diabetes, Impaired Glucose Regulation
- Trial name
- NCT04283942
- Testing
- Intermittent calorie restriction (ICR), Continuous calorie restriction (CCR)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Obesity
The Effects of Dairy Products on Energy Balance
The aim of the study is to investigate the long time effects of high and low intake of dairy products on fecal fat excretion, weight loss, blood pressure, lipid profile, lipid oxidation and appetite regulation in moderately…
- Trial name
- MEPEB (NCT01199835)
- Testing
- High Calcium intake from dairy products
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sleep Disturbance, Fatigue Syndrome, Chronic
Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation
Certain classical formulas in traditional Chinese medicine and dietary prebiotics have demonstrated beneficial effects on various aspects of suboptimal health status in previous studies.
- Conditions
- Sleep Disturbance, Fatigue Syndrome, Chronic, Endocrine Disorder, Glucose Metabolism Disorder
- Trial name
- NCT07774897
- Testing
- Combination product (Bao Yuan Tang full-component extract 2.0g and galactooligosaccharides 2.0g), Galactooligosaccharides 2.0g
- Where
- 6 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Appetite, Satiety
Effect of Sourdough Bread Consumption on Postprandial Responses, Appetite Regulation and Energy Intake
During this project the effect of yeast bread and sourdough breads consumption on satiety, energy intake at subsequent meal and postprandial metabolic responses, will be investigated.
- Conditions
- Appetite, Satiety, Energy Intake, Glucose Response
- Trial name
- SPAR (NCT06015867)
- Testing
- Dietary Intervention with Wholemeal Bread with Yeast, Dietary Intervention with Wholemeal Sourdough Bread
- Where
- 2 sites in Belgium
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Postprandial Glucose Regulation
Health Effects of Oat and Oat Polar Lipids in Human
Aim of the study is to investigate health effects of oats and oat derived components, in human intervention studies, with the purpose to build new knowledge for development of cardiometabolic protective foods.
- Trial name
- NCT05139355
- Testing
- Effects of Oat and Oat Components on Cardiometabolic risk variables
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity, Dyslipidemia
Regulation of Lipoprotein Metabolism in Obese Men
Visceral obesity is strongly associated with dyslipidaemia (hypertriglyceridaemia, low HDL-cholesterol and mildly elevated LDL-cholesterol) and insulin resistance, key characteristics of metabolic syndrome (MetS).
- Conditions
- Obesity, Dyslipidemia, Insulin Resistance
- Trial name
- NCT00392717
- Testing
- Atorvastatin, Fish oils
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The University of Western Australia
Pre Diabetes
Assessment of the Impact of a Personalised Nutrition Intervention in Impaired Glucose Regulation
This study will determine if DNA-based dietary guidelines can improve glucose regulation in pre-diabetic individuals significantly more than standard dietary guidelines following 6 weeks of the intervention.
- Trial name
- ASPIRE-DNA (NCT03702465)
- Testing
- DNA-based dietary intervention, DNA-based dietary intervention using an app, Control arm
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London