Clinical trials: Glucose Response, open to volunteers
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Type 1 Diabetes, Hypoglycemia
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
The objectives of this study are to examine how sex hormones (use of hormonal birth control, menstrual cycle phase) impact glycemic control among women with type 1 diabetes (T1D), and to test adjustments to insulin dosing and…
- Conditions
- Type 1 Diabetes, Hypoglycemia, Hyperglycaemia Due to Type 1 Diabetes Mellitus, Menstruation Disturbances
- Trial name
- MERIT (NCT06297980)
- Testing
- Personalized modifications to treatment to address menstrual cycle effects on glycemia
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Glucose, High Blood
Dose Response Study of Transdermal Human Insulin in Patients
A 21-Day open label study of transdermally delivered human insulin in Type 2 Diabetics as measured by response of down modulation of glucose after dosing of Insulin as compared to historic patient response to injected insulins.
- Trial name
- LEVPS (NCT05159453)
- Testing
- Human Insulin, Finger-actuated, Metered Pump Sprayer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Transdermal Delivery Solutions Corp
Diabetes Mellitus, Blood Sugar
Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit
Researchers at the Department of Intensive Internal Medicine and the Department of Endocrinology and Diabetology will conduct a study to verify the accuracy and safety of the new Syai Tag system for continuous glucose monitoring…
- Conditions
- Diabetes Mellitus, Blood Sugar, Sepsis, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT07448805
- Testing
- continuous glucose monitor
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Prediabetes / Type 2 Diabetes
A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes
This is a randomized, single-blind, controlled, parallel clinical trial to examine the efficacy and safety of AMPK Charge+® with and without use of semaglutide on glycemic response in adults with prediabetes or Type 2 Diabetes.
- Trial name
- NCT07195994
- Testing
- AMPK Charge+®, AMPK Charge+® with semaglutide
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- QuickSilver Scientific
Gestational Diabetes, Pregnancy Related
Studying Phenotypes of Gestational Diabetes Mellitus in an Asian Pregnant Cohort
Gestational diabetes mellitus (GDM) is a transient hyperglycemic condition identified during pregnancy in women without a history of chronic diabetes.
- Conditions
- Gestational Diabetes, Pregnancy Related, Pregnancy Complications, Birth Weight
- Trial name
- GDM-CARE (NCT06542718)
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- National University Health System, Singapore
Diabetes
Body Composition, Fitness, and Thermoregulation in Young Boys With Type I Diabetes vs. Healthy Soccer Players
The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers.
- Trial name
- BCFTYR (NCT06676878)
- Testing
- Incremental exercise
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paweł Korman
Post Bariatricsurgery, Hypoglycemia
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
RYGB (roux-en-y gastric bypass) has been reported to reverse type 2 diabetes (T2DM) immediately after surgery before any significant weight loss.
- Trial name
- NCT00992901
- Testing
- Exendin-(9-39), Atropine, GLP-1 and GIP
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Exercise, Healthy Participants
Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial
The goal of this clinical trial is to investigate if blood glucose responses are similar between and within individuals in response to standardized exercise in adults with and without Type 1 diabetes.
- Conditions
- Exercise, Healthy Participants, Glucose Variability, Type 1 Diabetes (T1D)
- Trial name
- NCT07209930
- Testing
- Exercise, Rest
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Obesity, Metabolic Syndrome
Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)
This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly…
- Conditions
- Obesity, Metabolic Syndrome, Brown Adipose Tissue
- Trial name
- BAT-Sema (NCT07621640)
- Testing
- Semaglutide (Wegovy®), ¹⁸FDG-PET/CT with cold stimulation, Liver MRI (PDFF + MRE)
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University
Gestational Diabetes Mellitus (GDM), Type 2 Diabetes (T2DM)
Women With Previous GDM and the Effects of HIIT.
The goal of this clinical trial is to investigate if women with previous gestational diabetes (pGDM) are characterized with unique metabolic and molecular alterations compared to women without pGDM.
- Conditions
- Gestational Diabetes Mellitus (GDM), Type 2 Diabetes (T2DM), High-intensity Interval Training
- Trial name
- GDM-HIIT (NCT07566845)
- Testing
- High-intensity interval training
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Glucose Metabolism Disorders (Including Diabetes Mellitus)
The Effect of Chlorhexidine Mouthwash on Postprandial Glucose Response in Healthy Individuals
The digestion of carbohydrates begins in the mouth through the salivary enzyme amylase which breaks food starches into maltose and disaccharides.
- Trial name
- NCT07172009
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Overweight, Obesity
Glycaemic Response of Arabic Bread
Bread remains one of the most widely consumed staple foods worldwide, with wheat flour serving as its traditional foundation. However, the widespread dependence on refined wheat-based bread has paralleled the rising prevalence of…
- Conditions
- Overweight, Obesity, Glycaemic Response
- Trial name
- NCT07652320
- Testing
- Control Bread, Chickpea-Enriched Arabic Bread, Pea-Enriched Arabic Bread
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
PreDiabetes, Diabetes Mellitus, Type 2
Post Prandial Individual Responses to Different Foods
This study aims to understand why people respond differently to the same foods, especially when it comes to changes in blood sugar after eating.
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT06989164
- Testing
- Post prandial testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Insulin Response, Type 1 Diabetes
Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring
Noninvasively monitoring insulin is crucial for advancing precision nutrition and promoting healthy living by enabling a deeper understanding of individual metabolic responses to dietary intake.
- Trial name
- NCT07254364
- Testing
- Standardized meal 1
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Type 1 Diabetes Mellitus
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin
Sodium glucose cotransporter 2 (SGLT2) inhibitors are a type of medicine that help the kidneys get rid of extra sugar in the blood through urine.
- Trial name
- KETO-TRACK (NCT07225465)
- Testing
- FORXIGA
- Where
- 4 sites in Australia
- Volunteers
- 115 people
- Sponsor
- St Vincent's Hospital Melbourne
PreDiabetes
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes.
- Trial name
- NCT05119179
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cystic Fibrosis
Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis
In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this…
- Trial name
- NCT06163482
- Testing
- Mixed meal
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Exercise Physiology, Nutritional Supplementation
Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run
This study will examine how three commonly used pre-run nutritional supplements-caffeine, L-citrulline, and an exogenous ketone supplement-affect physiological and perceptual responses during a fixed-pace 5 km treadmill run in…
- Trial name
- NCT07854223
- Testing
- Caffeine, L-Citrulline, Exogenous Ketone (Beta-Hydroxybutyrate)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Type 2 Diabetes, Insulin Dependent Diabetes
Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test.
- Trial name
- MT2D (NCT07650682)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology