Clinical trials: Glucose Variability
Diabetes Mellitus, Type 2
Post Prandial Glucose (PPG) Study of Empagliflozin in Japanese Patients With Type 2 Diabetes Mellitus
To evaluate the efficacy of empagliflozin administered orally once daily in postprandial glucose and 24-hour glycaemic variability compared to placebo given for 4 weeks as mono-therapy in Japanese patients with type 2 diabetes…
- Trial name
- NCT01947855
- Testing
- Empagliflozin
- Where
- 2 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus Type 2
Medium-term Effects of a Polyphenol-rich Beverage Based on Red Grape Pomace Extract on Non-alcoholic Fatty Liver Disease, Cardiometabolic Risk Profile and Gut Microbiota in Subjects with Type 2 Diabetes
Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by an abnormal accumulation of fat not due to alcohol or drug consumption that can evolve into steatohepatitis (NASH), fibrosis and cirrhosis.
- Trial name
- PoLiFat (NCT06895018)
- Testing
- Supplementation with Polyphenol Rich Drink
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Critical Illness, Hyperglycemia
Stress Hyperglycemia Ratio and Glucose Variability in Critically Ill Patients
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.
- Trial name
- NCT07892222
- Volunteers
- 75 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Coronary Heart Disease
Glycemic Variability, Gut Microbiota, and Prognosis in T2DM With ACS
Patients with type 2 diabetes mellitus (T2DM) diagnosed with acute coronary syndrome (ACS) by coronary angiography in the Second Affiliated Hospital of Nanchang University were consecutively included in a prospective cohort…
- Trial name
- NCT06573060
- Testing
- Continuous glucose monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Diabetes
Effect of Preoperative Oral Carbohydrates on the Glycemic Variability of Diabetic Patients
Preoperative carbohydrate drink intake attenuate insulin resistance. However, carbohydrate loading may compromise blood glucose control in patients with diabetes.
- Trial name
- NCT04013594
- Testing
- carbohydrate group
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Gestational Diabetes, Continuous Glucose Monitoring
Glucose Variability in Pregnancy Complicated by Diabetes
Continuous glucose monitoring (CGM) methods provide details of magnitude and duration of glucose fluctuations, giving a unique insight on daily blood sugar control.
- Conditions
- Gestational Diabetes, Continuous Glucose Monitoring, Glycemic Variability
- Trial name
- NCT01883622
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova
Type-2 Diabetes
Walnuts and Glucose Variability
Persons with type 2 diabetes mellitus (T2DM) have swings in their blood sugar levels that may lead to a higher risk of developing heart disease.
- Trial name
- NCT01787214
- Testing
- Full dose, Half dose, Control
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Loma Linda University
Blood Glucose Variability, Cardiac Surgical Procedures
Glycemic Variability and Autonomic Nervous System in Cardiac Surgery Patients
On-pump coronary artery bypass graft (CABG) and valve replacement surgeries are high-risk procedures. Among the risk factors for postoperative complications, perioperative hyperglycemia and blood glucose variability have been…
- Conditions
- Blood Glucose Variability, Cardiac Surgical Procedures, Autonomic Nervous System
- Trial name
- CAESAR (NCT05454735)
- Testing
- coronary artery bypass surgery, aortic valve replacement surgery
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Type 1 Diabetes (T1D), Nutrition Therapy
Meal Frequency and Glycemic Control in Individuals With Type 1 Diabetes
The goal of this clinical trial is to examine the effect of 3 versus 6 daily meals of isocaloric diets on glycemic control and variability in individuals with type 1 diabetes.
- Conditions
- Type 1 Diabetes (T1D), Nutrition Therapy, Glycemic Control for Diabetes Mellitus
- Trial name
- NCT06934707
- Testing
- Three meals a day, Six meals a day
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline
Glucose Variability and Cognition in Prediabetes
This study examines the association of variability in glucose values over a 10-day period with cognitive function and AD risk markers among individuals with prediabetes, aged 50 or older.
- Conditions
- Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging
- Trial name
- NCT04201600
- Testing
- Continuous Glucose Monitoring System (CGMS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 2, Metabolic Disease
The Effect on Metabolism, Food Intake and Preferences of a Knockout Gene Variant Involved in Carbohydrate Metabolism
Around 10% has type 2 diabetes in Greenland, despite being a practically unknown disease only six decades ago. The drastic increase is of great concern, especially considering the transition that have occurred during the same…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Disease, Sucrose Intolerance Congenital, Sucrase Isomaltase Deficiency
- Trial name
- NCT05375656
- Testing
- Cross-over study
- Where
- 2 sites in Greenland
- Volunteers
- 38 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes Mellitus
Comparison of Vildagliptin vs. Glimepiride on Glucose Variability in Metformin Uncontrolled Type 2 Diabetic Patients
Compare the effect of Vildagliptin plus Metformin versus Glimepiride plus Metformin on glucose variability in T2DM patients.
- Trial name
- VARIABLE (NCT01910441)
- Testing
- Vildagliptin, Glimepiride, Metformin
- Volunteers
- 95 people
- Sponsor
- Novartis Pharmaceuticals
Type 1 Diabetes, Continuous Glucose Monitoring
The Effect of Frequent Continuous Glucose Monitoring Use on Glucose Variability in Preschoolers With Type 1 Diabetes
The purpose of this study is to determine whether continuous glucose monitoring will improve glucose variability as measured by the coefficient of variation of glucose levels in very young children with T1D.
- Conditions
- Type 1 Diabetes, Continuous Glucose Monitoring, Children, Glucose Variability
- Trial name
- NCT04558710
- Where
- Slovenia
- Volunteers
- 339 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Diabetes Mellitus, Type 1
Dapagliflozin in Physical Exercise in Type 1 Diabetes
Inhibitors of sodium-dependent glucose-transporter 2 (SGLT-2 inhibitors, including dapagliflozin) inhibit glucose reabsorption in renal tubular cells, hereby increasing glycosuria in the hyperglycemic state.
- Trial name
- NCT04049110
- Testing
- Forxiga 10mg
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 1 Diabetes
Expanding Coverage of Continuous Subcutaneous Insulin Infusion in Pediatric Patients With Diabetes
The purpose of the study is to present evidence based literature and clinical data to the medical directors at Missouri Medicaid to help modify the existing policy regarding insulin pump therapy in pediatric patients with…
- Trial name
- NCT00829062
- Testing
- Continuous glucose glucose sensor- physician ordered
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Type 1 Diabetes Mellitus
Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patients
The transition from the Pediatric clinic to the adult care is a challenging period for young adults with type 1 diabetes, due to the high risk of poor glycemic control.
- Trial name
- METRO (NCT03463564)
- Testing
- Insulin pump, Insulin injections
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hypoglycemia
Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide
Idiopathic reactive hypoglycemia (IRH) describes a condition where recurrent episodes of symptomatic hypoglycemia occurs one to four hours after a meal, usually following meals rich in carbohydrates.
- Trial name
- NCT00802971
- Testing
- FOS
- Volunteers
- 12 people
- Sponsor
- Asker & Baerum Hospital
Diabetes Mellitus, Type 2
Effectiveness of Exenatide Plus Dapagliflozin on 24 Hour Glucose Variability Measured by CGM. A Proof of Concept.
This is a Phase IV, single site, randomized, open-label, parallel study comparing BYDUREON-BCise plus FARXIGA to BYDUREON-BCise alone and FARXIGA alone in patients diagnosed with Type 2 Diabetes Mellitus (T2DM) on a stable dose…
- Trial name
- NCT03970044
- Testing
- Exenatide 2 MG, Dapagliflozin 10 MG
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Consano Clinical Research, LLC
Diabetes Mellitus, Type 1, Hypoglycemia
International Navigator Hypoglycaemia Study
The purpose of this study is to determine if the incidence and duration of hypoglycaemia (low blood sugar) is reduced through the use of the FreeStyle Navigator Continuous Glucose Monitoring System in people with Type 1 diabetes…
- Trial name
- NCT00843609
- Testing
- Navigator continuous glucose monitor (Freestyle Navigator®)
- Where
- 3 sites in Israel, Slovenia and 1 more
- Volunteers
- 122 people
- Sponsor
- University Medical Centre Ljubljana
Critical Illness
Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets.
- Trial name
- NCT03003507
- Testing
- Enteral Formula With Fructose, Enteral Formula Without Fructose
- Volunteers
- 25 people
- Sponsor
- Hospital Moinhos de Vento