Clinical trials: Glutathione
Repetitive Head Impacts
Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation
The goal of this clinical trial is to test whether the gamma - glutamylcystiene (GGC) oral supplement can reach the brain and subsequently increase antioxidant glutathione (GSH) level in people with repetitive head impact (RHI).
- Trial name
- RHIGSH (NCT07050173)
- Testing
- Gamma-glutamylcysteine (GGC)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pravat Mandal
Non-alcoholic Fatty Liver Disease
Serine Supplementation for Obese Subjects With Fatty Liver Disease
In this study, the investigators aim to increase the liver tissue level of GSH in NAFLD patients by short-term dietary serine supplementation and improve their liver function by lowering the oxidative stress resulting from…
- Trial name
- NCT02599038
- Testing
- Serine supplementation
- Where
- 2 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- Hanns-Ulrich Marschall
Healthy
The Efficacy of Topical Serum X for Skin Brightening
This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening.
- Trial name
- NCT05693948
- Testing
- Other: Serum X
- Where
- Malaysia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- USMARI Research & Innovation Centre
Type 2 Diabetes
The Impact of Oral Glutathione on Oxidative Damage and Glycated Hemoglobin (HbA1c) Levels in Type 2 Diabetes Patients
This trial aims to assess the effectiveness of L-glutathione, supplemented with bioavailability boosters (tannin, low molecular weight chitosan, and polyethylene glycol), on improving antioxidant levels and glycemic control in…
- Trial name
- NCT06313164
- Testing
- enhanced glutathione
- Where
- Russia
- Volunteers
- 217 people
- Sponsor
- S.LAB (SOLOWAYS)
Amyotrophic Lateral Sclerosis
Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)
This is a multi-center, 20-week study of inosine treatment. Study Objectives and Endpoints The primary objective of the study is to determine the safety and tolerability of oral administration of inosine (administered daily)…
- Trial name
- SURE-ALS2 (NCT03168711)
- Testing
- Inosine
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Tuberculosis, Pulmonary, HIV/AIDS
RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection
Although tuberculosis is a treatable disease, it is currently the infectious disease with the highest mortality in the world. It is estimated that one-third of the world's population is infected.
- Trial name
- RIPENACTB (NCT03281226)
- Testing
- RIPE (2m) and RI (4m), RIPE+NAC (2m) and RI (4m)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Oxidative Stress, Alzheimer's Disease
Human Brain Antioxidants During Oxidative Stress
Antioxidants are important for having a good memory and for smart thinking when people get old, and that is important for everyone's quality of life.
- Conditions
- Oxidative Stress, Alzheimer's Disease, Aging
- Trial name
- NCT01713816
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Skeletal Muscle Performance, Gene Polymorphisms
Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance
Study aims to verify the hypothesis: N-acetylcysteine (NAC) supplementation improves exercise capacity in people training endurance sports and the effectiveness of this supplementation depends on the polymorphism of genes related…
- Trial name
- NCT05604586
- Testing
- N-acetylcysteine
- Where
- Poland
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Protein-energy Malnutrition, Kwashiorkor
Study of Antioxidants and Oxidants in Malnourished Children
It is believed that the organs of severely malnourished children malfunction because harmful compounds called oxidants injure the tissues in these organs.
- Conditions
- Protein-energy Malnutrition, Kwashiorkor, Marasmus
- Trial name
- NCT00069134
- Testing
- sulfur amino acids
- Where
- Jamaica
- Volunteers
- 86 people
- Sponsor
- Baylor College of Medicine
Covid19
Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19
COVID-19 is associated with increased mortality, and has been linked to a 'cytokine inflammatory storm'. Populations at higher risk of COVID complications and mortality include the elderly, diabetic patients and immunocompromised…
- Trial name
- NCT04703036
- Testing
- Glycine, N-acetylcysteine, Alanine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
Post-polio Syndrome, Physical Activity
Glutathione and Health With Post-Polio Syndrome
In this study, people who have symptoms of post polio will take oral glutathione supplements for three months. Their levels of fatigue, physical activity and sleep efficiency will be assessed.
- Conditions
- Post-polio Syndrome, Physical Activity, Depression, Pain
- Trial name
- NCT01402570
- Testing
- Glutathione
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Parkinson Disease
N-Acetylcysteine for Neuroprotection in Parkinson's Disease
The overall objective of this developmental/exploratory study is to use noninvasive proton magnetic resonance spectroscopy (1H MRS) to assess (a) whether brain levels of the antioxidant glutathione (GSH) are decreased in vivo, as…
- Trial name
- NAC for PD (NCT01470027)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Busulfan Pharmacokinetic Analysis, Busulfan Dosing
26DT052; Scaling Busulfan Dose to Body Surface Area in Children
The goal of this pilot study is to determine if scaling the first busulfan dose to Body Surface Area (BSA) in children with a BSA ≥0.5 m2 and using a BSA-banded dosing table for infants (BSA <0.5 m2) increases the fraction of…
- Conditions
- Busulfan Pharmacokinetic Analysis, Busulfan Dosing, Hematopoietic Stem Cell Transplant (HSCT), Busulfan
- Trial name
- NCT07792369
- Testing
- Busulfan (BU)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital of Philadelphia
Alcohol Drinking
Effect of Glutathione on Blood Alcohol and Hangover Symptoms
Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.
- Trial name
- NCT00127309
- Testing
- Glutathione
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Piyavate Hospital
Busulfan Pharmacokinetic Analysis, GST Genetic Polymorphism
Busulfan Pharmacokinetic Analysis and GST Polymorphism in Adults Undergoing Hematological Stem Cell Transplantation
Between 100 up to 200 adults undergoing HSCT for their primary disease will be included in this pharmacokinetic/pharmacogenetic study. In the preparative protocol Busulfan (BU)will be included as indicated in a known protocol.
- Trial name
- NCT01071486
- Testing
- Hematological Stem Cell Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Non-Small Cell Lung Cancer, Chemotherapy
Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC
Chemotherapeutic agents exert significant immunomodulatory effects by influencing tumor-infiltrating immune cells. However, the sequence and combination of chemotherapy regimens differentially modulate immune cell dynamics…
- Conditions
- Non-Small Cell Lung Cancer, Chemotherapy, PD1 Antibody, Glutathione
- Trial name
- NCT06896422
- Testing
- Glutathione, PD1 Inhibitor, Chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Low-Calorie Diet, Diet, High-Protein
The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases.
- Conditions
- Low-Calorie Diet, Diet, High-Protein, Obesity; Pituitary, Weight Cycling
- Trial name
- NCT03374150
- Testing
- diet counseling
- Where
- 2 sites in Indonesia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
HIE - Perinatal Hypoxic - Ischemic Encephalopathy
NVD in Hypothermic HIE Neonates
Neonatal hypoxic ischemic (HI) injury is an unpredictable neurologic injury with devastating, long term consequences for parents who are expecting a normal child.
- Trial name
- NCT04643821
- Testing
- N-acetylcysteine, NAC, and calcitriol
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Chronic Pain, Elderly
Paracetamol and Glutathion
Paracetamol is one of the most widely used analgesics in the world especially for chronic pain in the elderly. The metabolism of paracetamol occurs in the liver and involves the use of glutamyl-cysteinyl-glycine (Glutathione…
- Trial name
- NCT01116596
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Type 2 Diabetes, Oxidative Stress
The Production of Reactive Oxygen Species in Response to Glutathione Supplementation and Acute Exercise
Objectives: The research focus of the study is the production of reactive oxygen species (ROS) in patients with type 2 diabetes (T2D) in response to glutathione (GSH) supplementation and in response to acute exercise.
- Conditions
- Type 2 Diabetes, Oxidative Stress, Mitochondrial Reactive Oxygen Species Production
- Trial name
- DIMITOS (NCT02948673)
- Testing
- Glutathione
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen