Clinical trials: Gluten Intolerance
Celiac Disease, Dentin Hypersensitivity
Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients
This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel…
- Conditions
- Celiac Disease, Dentin Hypersensitivity, Tooth Demineralization
- Trial name
- CELIADENT (NCT07069127)
- Testing
- Biorepair Toothpaste and Mousse, Biorepair® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Not-celiac Gluten Sensitivity
Diagnostic Significance of Positive EmA Antibodies in the Duodenal Culture Medium of Not-Celiac Wheat Sensitivity (NCWS)
The most frequent diseases caused by wheat ingestion are T cell-mediated disorders, i.e. celiac disease and immunoglobulin E (IgE)-mediated allergic reactions.
- Trial name
- NCWS (NCT02203201)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Celiac Disease in Children, Celiac Disease
Development of CELIAC-Q KIDS: A Patient-Reported Outcome Measure for Pediatric Celiac Disease
A multicentre, prospective observational study to develop the CELIAC-Q KIDS patient reported outcome measure for children and adolescents with celiac disease.
- Conditions
- Celiac Disease in Children, Celiac Disease, Patient-reported Outcome Measures
- Trial name
- NCT05548166
- Testing
- Interview and scale development
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Inflammatory Bowel Diseases, Circadian Dysregulation
Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
- Trial name
- NCT03662646
- Testing
- no intervention performed- observational only
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Non-celiac Wheat Sensitivity
Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients
Recently it has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have CD or wheat allergy.
- Trial name
- NCT03022994
- Testing
- Duodenum and rectum examination
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Palermo
Celiac Disease, Eosinophilic Esophagitis
Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease
Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics.
- Trial name
- NCT02190513
- Volunteers
- 56 people
- Sponsor
- St. John Health System, Michigan
Celiac Disease in Children
Celiac Disease in Children
The aim is to study the clinical, serological, endoscopic and histopathological characteristics and treatment outcome of children diagnosed with celiac disease in Sohag University Hospital
- Trial name
- NCT06783673
- Testing
- Upper GIT endoscopy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Sohag University
Pancreatic Cancer Non-resectable, Tumor Pancreas
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment.
- Conditions
- Pancreatic Cancer Non-resectable, Tumor Pancreas, Pain Cancer
- Trial name
- NCT06160323
- Testing
- EUS-guided coeliac ganglion neurolysis / celiac plexus neurolysis
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- Chinese University of Hong Kong
Celiac Disease, Gluten
HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease
The investigators will evaluate the use of an HLA-DQ2-gliadin tetramer for staining of gluten specific T cells in the diagnostics of uncertain celiac disease.
- Trial name
- NCT01100099
- Testing
- Gluten challenge.
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Non-celiac Wheat Sensitivity
KIR Genes and Non-Celiac Wheat Sensitivity
Non-celiac gluten sensitivity (NCGS) is a condition characterized by gastrointestinal and extraintestinal symptoms which are triggered by gluten ingestion in the absence of celiac disease (CD) and wheat allergy.
- Trial name
- NCT05469971
- Testing
- KIR genotyping
- Where
- 4 sites in Italy
- Volunteers
- 170 people
- Sponsor
- University of Palermo
Coeliac Disease
Interest of Urinary Measurement of Immunogenic Gluten Peptides (GIP) in the Follow-up of Pediatric Celiac Patients.
The main reason for insufficient control of celiac disease is non-adherence to the gluten-free diet (GFD), whether voluntary or involuntary. In children, involuntary exposures are common (canteens, snacks, restaurants).
- Trial name
- GIped (NCT07578038)
- Testing
- Urinary measurement of GIP, Usual follow-up and measurement of urinary GIP.
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Lenval
Celiac Disease
Assessment of Gluten-Free Availability in Elaborated Food Stores in Three Neighbourhoods of Buenos Aires City
Celiac disease (CD) is a chronic autoimmune disorder in genetically susceptible individuals characterized by inflammation of the small intestine due to gluten intolerance.
- Trial name
- NCT02312349
- Where
- Argentina
- Volunteers
- 112 people
- Sponsor
- Hospital Italiano de Buenos Aires
Celiac Disease
Prospective Study of Undiagnosed Celiac Disease
Direct benefits to the participants, who are diagnosed with celiac disease may be substantial and could include lessening or prevention of GI symptoms, correction of biochemical abnormalities and reduction in risk for…
- Trial name
- NCT01317914
- Testing
- Dietary instruction
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Celiac Disease, Cerebellar Ataxia
Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia
This study will screen patients with cerebellar ataxia to check for antibodies that indicate allergy to gluten (wheat protein) and will study the effect of a gluten-free diet in patients with these antibodies.
- Conditions
- Celiac Disease, Cerebellar Ataxia, Healthy
- Trial name
- NCT00006492
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Celiac Disease, Adults With Celiac Disease
The Effect of a Navigator Nurse- Supported Mobile Application Developed Based on the IMB Model on the Quality of Life of Patients With Celiac Disease
This randomized controlled trial aims to evaluate the effect of a navigator nurse-supported mobile application, developed based on the Information-Motivation-Behavioral Skills (IMB) model, on the quality of life of adult patients…
- Trial name
- NCT07177287
- Testing
- IMB navigator app
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Celiac Disease in Children, Celiac Disease in Adolescents
Effect of Adherence to a Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease
The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac…
- Trial name
- NCT07382999
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Inonu University
Celiac Disease
Impact of Gluten Contamination in Celiac Patients Clinically Responsive and Unresponsive to the Gluten-free Diet
The primary aim of the study is to detect the presence of gluten immunogenic peptides (GIP) in urine samples from celiac patients on a gluten-free diet clinically responsive and non-responsive to dietary treatment and from…
- Trial name
- GIP (NCT05066191)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Celiac Disease
A Study to Evaluate Gluten Challenge on Immune Responses in Subjects With Celiac Disease
This is a model development, open label, no therapeutic treatment, three sequential group, short term-gluten challenge study in subjects with celiac disease. Immune responses are evaluated following gluten challenge.
- Trial name
- NCT03521180
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Celgene
Celiac Disease
Teriflunomide vs. Placebo During Gluten Challenge in Celiac Disease
The investigators will see if the drug teriflunomide (which is in use in other immune disorder (multiple sclerosis)) can inhibit the immune activation in celiac disease patients during a 3 day gluten challenge.
- Trial name
- NCT04806737
- Testing
- Teriflunomide Oral Tablet
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Non-celiac Wheat Sensitivity
Self-reported Non-celiac Wheat Sensitivity (NCWS) in Patients Undergoing Digestive Endoscopy
Self-reported food hypersensitivity is common, particularly in women, with a reported prevalence of about 20% in the UK community.
- Trial name
- NCT04154137
- Testing
- Questionnaire
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Palermo