Clinical trials: Gluten-Sensitive Enteropathy
Non-celiac Gluten Sensitivity, Non-celiac Wheat Sensitivity
Autoimmune Diseases and Serum Autoantibodies in NCWS and IBS Patients
In recent years, a new gluten- or wheat-related disease has emerged, a condition labelled "non-celiac gluten sensitivity" (NCGS) or "non-celiac wheat sensitivity" (NCWS).
- Trial name
- NCT04077840
- Where
- 2 sites in Italy
- Volunteers
- 58 people
- Sponsor
- University of Palermo
Celiac Disease, Small Bowel Mucosal Atrophy or Lesions
AI System for Detection and Characterization of Chronic Enteropathies
Coeliac disease (CD) is an immune-mediated enteropathy leading to small intestinal mucosal atrophy. Diagnosis relies on serology and duodenal biopsies, but it can be complicated by patchy lesions and differential diagnosis with…
- Conditions
- Celiac Disease, Small Bowel Mucosal Atrophy or Lesions, Non-celiac Enteropathies
- Trial name
- NCT07387185
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Celiac Disease
Prebiotic as a Supplement of Gluten-free Diet in the Management of Celiac Disease in Children
Prebiotics are known as substances affecting beneficially the organism by restoring the intestinal microbiota balance, stabilizing the intestinal barrier and modulating the endocrine and immune functions.
- Trial name
- NCT03064997
- Testing
- Synergy 1
- Where
- 2 sites in Poland
- Volunteers
- 34 people
- Sponsor
- Polish Academy of Sciences
Celiac Disease
A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease
A randomized, double-blind, placebo-controlled Phase 2B study to evaluate the efficacy and safety of Larazotide Acetate in the treatment of patients with celiac disease who have persistent symptoms despite being on a gluten-free…
- Trial name
- NCT01396213
- Testing
- Larazotide Acetate
- Where
- 62 sites in United States, Canada
- Volunteers
- 342 people
- Sponsor
- 9 Meters Biopharma, Inc.
Celiac Disease
A Phase 1, Study of the Safety and Tolerability of ALV003 in Healthy Adult Volunteers and Subjects With Well-Controlled Celiac Disease
To assess safety and tolerability of ALV003 in healthy volunteers and patients with Celiac Disease
- Trial name
- NCT00626184
- Testing
- 4 dose levels of ALV003
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Alvine Pharmaceuticals Inc.
Celiac Disease in Children
Support for Adolescents With Celiac Disease
This study was designed as a randomized controlled experimental study to examine the effects of peer-interaction group support in adolescents with celiac disease (CD) in the 13-18 age group on the quality of life, friendship…
- Trial name
- NCT04533776
- Testing
- Celiac Disease Definition, Symptoms and Treatment, Difficulties Due to Celiac Disease, Gluten Free Diet in Celiac Disease
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Melike Taşdelen Baş
Mediastinal Tumours and Lymph Nodes, Celiac, Perigastric and Peri-pancreatic Lymph Nodes
Controlled Trial Comparing the Performance of 22 Gauge Versus 25 Gauge EUS-FNA Needles (FNA-22G-25G)
The aim of the study is to compare the performance characteristics of EUS-FNA 22 Gauge needle and EUS FNA 25 Gauge needle in terms of cellularity and diagnostic yield for diagnosis of various pathologies, including lymph nodes…
- Conditions
- Mediastinal Tumours and Lymph Nodes, Celiac, Perigastric and Peri-pancreatic Lymph Nodes, Pancreatic Masses, Liver Masses
- Trial name
- NCT01016288
- Where
- 9 sites in Denmark, Germany and 1 more
- Volunteers
- 135 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Regional Anaesthesia, Anesthesia and Analgesia
Comparison of the Efficacy of Celiac Plexus Blockade, ESP and Lidocaine Infusion Under OFA
Modern anesthesiology, in search of alternatives to opioid-based pain management, is turning to low-opioid and non-opioid protocols.
- Trial name
- LECO (NCT06793527)
- Testing
- Celiac Plexus Block, ESP block, Lidacaine
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Pancreatic Cancer
Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas
This study is performed to confirm whether resection of the nerve plexus on the right half of celiac and SMA associated with extended pancreatoduodenectomy could improve survival and relieve pain of pancreatic cancer patients.
- Trial name
- NCT02514928
- Testing
- resection of the nerve plexus on the right half of celiac and SMA associated with extended pancreatoduodenectomy, standard pancreatoduodenectomy
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Fudan University
Celiac Disease, Healthy
Imaging the Duodenum Using an Optical Frequency Domain Imaging OFDI Capsule
The study is being done to assess the tolerability and feasibility of a tethered OFDI capsule to image the duodenum. A total of 108 participants (36 healthy and 72 with clinically suspected or diagnosed Celiac disease) will be…
- Trial name
- NCT02202681
- Testing
- OFDI Capsule
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Celiac Disease, Coeliac Disease
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GSK3915393 in Healthy Participants and to Evaluate the Interaction Between GSK3915393 and Grapefruit Juice and Itraconazole
This is a 3-part first time into human study (FTIH) study for GSK3915393. Parts A and B of the study will evaluate the safety, tolerability and pharmacokinetics (PK) of single ascending and repeat oral doses of GSK3915393 in…
- Trial name
- NCT04604795
- Testing
- GSK3915393 Capsules, GSK3915393 Solution for Infusion, Itraconazole
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Celiac Disease
Serum Markers in Gluten Challenge
1. The purpose of this research study is to evaluate non-invasive markers of celiac disease activity in subjects that are on a gluten-free diet, in remission from celiac disease who undergo gluten challenge. 2.
- Trial name
- NCT00931892
- Testing
- Gluten
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Beth Israel Deaconess Medical Center
Clinical and Nutritional Safety.
Oat Products in the Treatment of Coeliac Disease in Children
In many Northern European countries oat-based products have been used in the dieto-therapy of coeliac disease for many years. The purpose of this study is to evaluate clinical tolerance and liking of gluten-free products…
- Trial name
- NCT00808301
- Testing
- Gluten-free products
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Heinz Italia SpA
Celiac Disease, Iron Deficiency
Celiac Disease and Unexplained Iron Deficiency in a Primary Care Setting
The purpose of this study is to determine if patients with unexplained iron deficiency have underlying diseases processes such as celiac disease.
- Conditions
- Celiac Disease, Iron Deficiency, Iron Malabsorption
- Trial name
- NCT02036944
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Providence Medical Research Center
Celiac Disease
A Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Celiac Disease
This study is designed to evaluate the efficacy and safety of AMG 714 for the attenuation of the effects of gluten exposure in adult patients with celiac disease during a gluten challenge.
- Trial name
- NCT02637141
- Testing
- AMG 714, Gluten Challenge
- Where
- 3 sites in Finland
- Volunteers
- 64 people
- Sponsor
- Amgen
Chronic Pain
Radiofrequency Splanchnic Denervation Versus Retrocrural Neurolytic Celiac Block for Pancreatic Cancer Pain
The investigators will evaluate the analgesic efficacy of radiofrequency splanchnic nerve denervation versus neurolytic retrocrural celiac denervation for patients with abdominal pain due to cancer pancreas
- Trial name
- NCT03886298
- Testing
- radiofrequency splanchnic denervation, retrocrural celiac denervation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Celiac Disease
Celiac Disease Prevention
Celiac disease is an autoimmune disease induced by wheat gluten. Destruction of epithelial cells and microvilli on gut mucosa is causing a "flat mucosa" and an absorption defect.
- Trial name
- NCT00617838
- Testing
- Optimal gluten introduction
- Where
- Finland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Not-celiac Wheat Sensitivity
Bio-markers of Not-celiac Wheat Sensitivity
The aim of the investigators' study is to evaluate biochemical, immunological and histological characteristics of patients affected with the so-called "gluten (or wheat) sensitivity" who suffers from irritable bowel syndrome…
- Trial name
- NCT01762579
- Testing
- wheat flour, Xylose
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Gastrointestinal Diseases
ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden)
The ESPRESSO study is a collection of data from all computerised gastrointestinal histopathology reports in Sweden. This allows us to study risk factors for gastrointestinal disease, as well as the prognosis of gastrointestinal…
- Trial name
- ESPRESSO (NCT06371820)
- Testing
- ESPRESSO [The study has no intervention]
- Volunteers
- 13,000,000 people
- Sponsor
- Karolinska Institutet
Celiac Disease
Multicenter Study on the Toxicity of Gluten Traces in the Treatment of Celiac Disease
The purpose of this study is to evaluate the toxicity of minute doses of gluten in the treatment of celiac disease, a disorder characterized by permanent intolerance to dietary gluten.
- Trial name
- NCT00250146
- Testing
- Gluten (behaviour)
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Università Politecnica delle Marche