Clinical trials: Gluten-Sensitive Enteropathy
Irritable Bowel Syndrome
Gluten-free Diet in Irritable Bowel Syndrome
To evaluate the effects of a gluten-free diet in irritable bowel syndrome.
- Trial name
- NCT02528929
- Testing
- Gluten-free diet
- Volunteers
- 48 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Celiac Disease
Study of the Efficacy of Larazotide Acetate to Treat Celiac Disease
This study is designed to evaluate the efficacy of a single dose of larazotide acetate in preventing intestinal permeability changes induced by a 6-week gluten challenge in subjects with celiac disease
- Trial name
- NCT00889473
- Testing
- Larazotide acetate, Gluten 900 mg
- Where
- 15 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- 9 Meters Biopharma, Inc.
Celiac Disease in Children
Celiac Disease Prevention With Probiotics
Background/Aim: Celiac disease is a common immune-mediated disorder, and the only currently available treatment is a gluten-free diet.
- Trial name
- CiPP (NCT03176095)
- Testing
- Probiotic
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Lund University
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Celiac Disease, Nutritional Deficiency
Intestinal Permeability, Nutritional Status and Quality of Life in Celiac Disease
Celiac disease is defined as an autoimmune enteropathy with malabsorption of gluten protein. In recent studies, it has been stated that in individuals diagnosed with celiac disease, intestinal epithelial barrier integrity is…
- Conditions
- Celiac Disease, Nutritional Deficiency, Quality of Life
- Trial name
- NCT04351828
- Testing
- Blood draw once a time
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Marmara University
Non-celiac Gluten Sensitivity
Tolerability of an Ancient Grain in Patients With Non-Celiac Wheat Sensitivity
Patients suffering from wheat-related troubles, in absence of celiac disease or wheat allergy diagnosis, can suffer from non-celiac wheat sensitivity (NCWS).
- Trial name
- NCT06191432
- Testing
- Administration of Triticum Monococcum flour, Administration of Triticum Aestivum flour
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Palermo
Celiac Disease
Safety of Prolonged Administration of Triticum Monococcum in Celiac Disease
Preliminary studies on safety profile of Triticum Monococcum (Tm, a variety of Ancient Wheat) have provided conflicting results with some in vitro and ex vivo studies consistent with non toxicity and other suggestive of toxicity.
- Trial name
- NCT02220166
- Testing
- Triticum monococcum
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Università degli Studi di Brescia
Celiac Disease
A Decentralized Home-Based Study To Investigate Novel Objective Biomarker Of Gluten-Mediated Symptoms In Celiac Disease Participants (CeDar ROSE Study)
This is a decentralized study to primarily explore a novel objective digital biomarker (i.e., Gluten Dependency Index) for celiac disease-related responses triggered by gluten exposure using a wearable biosensor.
- Trial name
- NCT05686369
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Chugai Pharmaceutical
Pain, Chronic
Intraoperative Versus CT Guided Celiac Plexus Neurolysis in Unresectable Pancreatic Cancer
Many studies had stated that the coeliac plexus neurolysis (CPN) is a safe and effective treatment method of pain associated with pancreatic cancer.
- Trial name
- NCT03770247
- Testing
- Intraoperative celiac plexus neurolysis, CT guided celiac plexus neurolysis
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Celiac Disease
A Population-based Study of Celiac Disease in South Europe in Children Between 1 to 5 Years of Age
Celiac disease (CD) was diagnosed for years almost exclusively in children. This is due to the fact that in adulthood it manifests in a much more attenuated form, while the classic form with severe diarrhea, malnutrition and…
- Trial name
- HNCEL (NCT05968404)
- Volunteers
- 3,659 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Upper Abdominal Malignancies, Upper Gastrointestinal Cancer
Comparison of CT-Guided Celiac Plexus Neurolysis and Pharmacotherapy
After enrolment, patients were randomly assigned to two groups by means of a lottery procedure, whereby each patient blindly chose one of two labelled slips, resulting in group assignment to receive.
- Trial name
- NCT07761650
- Testing
- CT-guided celiac plexus neurolysis, Standard pharmacotherapy
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Mayo Hospital Lahore
Celiac Disease
Effects of Gluten Digestion With ALV003
This is a Phase 0, Double-blind study that will assess the effect of in vitro treatment of gluten with ALV003 or with placebo when ingested by CD Subjects.
- Trial name
- 0801 (NCT00859391)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Alvine Pharmaceuticals Inc.
Digestive System Disease
A Study of PVP001, PVP002, and PVP003 in Healthy Adults and PVP001 and PVP002 in Adults With Celiac Disease
It is hoped that different forms of the same medicine, called PVP001, PVP002, and PVP003, will help people with celiac disease. Both healthy adults and adults with celiac disease will take part in this study.
- Trial name
- NCT03701555
- Testing
- PvP001 100 mg, PvP001 300 mg, PvP001 900 mg
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Millennium Pharmaceuticals, Inc.
Celiac Disease, Celiac Disease in Children
Supporting Children and Young People to Live Well with Coeliac Disease
Managing a strict gluten-free diet is crucial for children and young people with coeliac disease. However, this can have adverse effects on psychological well-being and quality of life.
- Trial name
- NCT06007898
- Testing
- Parent self-help psychological resource
- Where
- 3 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Surrey
Celiac Disease
Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma Concentration
The inter- and intra-variability in the pharmacokinetic parameters of different formulations and doses of simvastatin in healthy subjects and in subjects with celiac disease in remission will be evaluated.
- Trial name
- NCT01642862
- Testing
- Simvastatin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity
Effects Gluten Intake on Body Composition, Energy Expenditure and Adipokine Profile in Non-celiac Women With Obesity
This is a double-masked, crossover, randomized, controlled study that aims to evaluate, in women with obesity, a possible influence of wheat gluten on food choices, body weight, resting metabolism and circulating inflammation…
- Trial name
- NCT03129932
- Testing
- gluten phase
- Volunteers
- 40 people
- Sponsor
- Jacqueline Isaura Alvarez Leite
Celiac Disease in Children, Eating Behaviors
Eating Behaviors in Children and Adolescents With/Without Celiac Disease
This observational study investigates the prevalence and severity of disordered eating behaviors in adolescents aged 11-17 years with celiac disease.
- Trial name
- NCT07285512
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Celiac Disease
Intestinal Transglutaminase Antibodies in Celiac Disease Diagnosis
Celiac disease (CD) is a systemic autoimmune gluten-dependent enteropathy in subjects with HLA DQ2/8. CD prevalence is more than 1% with a progression to 2% in adulthood.
- Trial name
- NCT05810441
- Testing
- Evaluation of diagnostic accuracy of anti-ttg-m
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- IRCCS Burlo Garofolo
Celiac Disease
Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients
To determine the effects of 12 weeks administration of different dose levels of ALV003 on the mucosal lining of the small intestine and symptoms in celiac disease patients.
- Trial name
- NCT01917630
- Testing
- ALV003
- Where
- 88 sites in United States, Canada and 4 more
- Volunteers
- 500 people
- Sponsor
- Alvine Pharmaceuticals Inc.