Clinical trials: Glycocalyx
Critical Illness
Glycocalyx Damage in Critically Ill Patients
The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related factors and to using organ-supporting measures. There is a correlation between length of organ support and GCX damage.
- Trial name
- NCT03146585
- Testing
- PBR assessment
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Hradec Kralove
Diabetes Mellitus, Type 2
Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
The prevalence of type 2 diabetes (T2D) continues to increase in the US, with 26.8 million adults carrying a diagnosis. Importantly, T2D is widespread in the Veteran population.
- Trial name
- NCT05205005
- Testing
- Endocalyx
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes Mellitus, Coronary Artery Disease
Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT03010683
- Testing
- Liraglutide, Metformin
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Anesthesia, Glycocalyx
Effect General and Regional Anesthesia on Glycocalyx
Observational study evaluating effect general or regional anaesthesia on glycocalyx by using perfused Boundary Region in sublingual microcirculation.
- Conditions
- Anesthesia, Glycocalyx, Perfused Boundary Region
- Trial name
- NCT02783443
- Testing
- General anesthesia, Regional anesthesia
- Volunteers
- 60 people
- Sponsor
- University Hospital Hradec Kralove
Endothelial Dysfunction
Evaluation of Lipid Emulsion on GCX in Critically Ill Patients
Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx. The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care.
- Trial name
- NCT03216850
- Testing
- Sublingual microcirculation assessment
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- University Hospital Hradec Kralove
Diabetes Mellitus, Type 2
Role of Neuraminidase Activity on Endothelial Dysfunction in Type 2 Diabetes
The objective is to determine if neuraminidase inhibition with zanamivir is efficacious as a therapeutic strategy to restore endothelial function in T2D patients.
- Trial name
- NAED (NCT04867707)
- Testing
- Zanamivir
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Missouri-Columbia