Clinical trials: Gonadal Steroid Hormones
Menstrual Cycle, Oral Contraceptive Use
Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes
A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of…
- Conditions
- Menstrual Cycle, Oral Contraceptive Use, Athlete
- Trial name
- Flow2Perform (NCT07591818)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Healthy
Reciprocal Influence of Sex Steroid Environment and Adipocyte Function in Men
Aromatase inhibition versus estradiol during 1 week
- Trial name
- NCT00740194
- Testing
- Aromatase inhibition, Estradiol
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Sickle Cell Disease, Vaso-occlusive Crisis
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease
This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD).
- Trial name
- NCT06345638
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Pennsylvania
Polycystic Ovary Syndrome
Effect of Magnesium Supplementation on Polycystic Ovary Syndrome
This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum insulin level is considered as a key variable and the sample size calculated 70 persons (35 persons for…
- Trial name
- NCT02178150
- Testing
- Magnesium Oxide
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Obesity, Hormone Disturbance
Bariatric Surgery, Hormones, and Quality of Life
The purpose of this study is to characterize the hormonal status in fertile women undergoing laparoscopic gastric bypass, pre- and postoperatively, and evaluate if there is a correlation between health-related quality of life and…
- Conditions
- Obesity, Hormone Disturbance, Quality of Life, Hyperandrogenism
- Trial name
- OBLIV (NCT03188640)
- Testing
- Laparoscopic gastric-bypass surgery
- Volunteers
- 68 people
- Sponsor
- Linkoeping University
Amenorrhea, Dysmenorrhea
Reproductive Effects of Pesticide, PCB and Mercury Exposure in Laotian Immigrants
This project is examining the reproductive effects of exposure to certain compounds that are suspected to act on the endocrine system, e.g. they may act like or interfere with hormones such as estrogen.
- Conditions
- Amenorrhea, Dysmenorrhea, Oligomenorrhea, Anovulation
- Trial name
- NCT00011388
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
HIV/AIDS, Gender
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development
To address the critical scientific gaps in PrEP safety for transgender youth and to plan for appropriate implementation of PrEP in transgender youth communities, the study will be conducted in 3 integrated phases.
- Conditions
- HIV/AIDS, Gender, Behavior and Behavior Mechanisms
- Trial name
- NCT04077138
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hektoen Institute for Medical Research
Male Infertility
Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
Today, it is evident that vitamin D (VD) has more widespread effects than the classical actions related to bone mineralization and calcium homeostasis1.
- Trial name
- NCT01304927
- Testing
- Cholecalciferol and calcium
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Transgender Persons, Pain Threshold
Perception of Pain During Gender Affirming Hormone Therapy
It is known from the literature that women and men differ in their perception of pain. Why this is the case has not been conclusively clarified. Sex hormones could have a significant influence on this.
- Conditions
- Transgender Persons, Pain Threshold, Perception of Pain, Sex Hormones
- Trial name
- NCT07148921
- Testing
- Quantitative Sensory Testing, Patient Health Questionnaire 9, Hormone concentrations
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Breast Cancer
Oral Aromatase Inhibitors Modify the Gut Microbiome
The purpose of this research is to study the bacteria in participants' gut before receiving a medicine called an aromatase inhibitor for breast cancer and after participants receive medicine for breast cancer.
- Trial name
- NCT05030038
- Testing
- Fecal swab collection, Blood samples
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Postoperative Nausea and Vomiting, Sex Hormone
Exogenous Sex Hormones and PONV
This study aims to investigate the rates of postoperative nausea and vomiting in transgender patients on hormone therapy compared to cisgender patients undergoing the same procedures (hysterectomy, orchiectomy, augmentation…
- Conditions
- Postoperative Nausea and Vomiting, Sex Hormone, Transgender
- Trial name
- NCT06816355
- Testing
- Orchiectomy, Hysterectomy, Augmentation mammoplasty
- Where
- United States
- Volunteers
- 7,348 people
- Sponsor
- Riverside University Health System Medical Center
Cardiovascular Diseases, Atherosclerosis
Analysis of Sex Hormones and Lipoproteins in Young Males
To analyze the relationship of sex hormones to lipoproteins in young males.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Heart Diseases
- Trial name
- NCT00037453
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn More About How Much of the Study Treatment Elinzanetant (or BAY3427080) Gets Absorbed, How Safe it is and How it Affects the Body in Healthy Female and Male Participants
Researchers are looking for a better way to treat men and women with vasomotor symptoms, a condition of having hot flashes caused by hormonal changes.
- Conditions
- Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes, Healthy Volunteers
- Trial name
- NCT05351892
- Testing
- Elinzanetant (BAY3427080)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bayer
Varicocele, Infertility
Varicocelectomy: Can Sex-hormones Predict Improvements in Semen Quality?
The purpose of this study is to determine if the pre-operative levels of sex-hormones can be used to identify the varicocele patients who can expect improvements in their semen parameters following varicocelectomy.
- Conditions
- Varicocele, Infertility, Semen Quality
- Trial name
- NCT01296230
- Testing
- Hormone and semen measurements before varicocelectomy
- Where
- 2 sites in Denmark
- Volunteers
- 3 people
- Sponsor
- Copenhagen University Hospital at Herlev
Major Depressive Disorder
Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression
Using an innovative multi-modal imaging approach, this study investigates the role of the neurochemical gamma-aminobutyric acid (GABA), brain activity, as well as hormones in understanding sex differences in Major Depressive…
- Trial name
- NCT03031665
- Where
- United States
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Multiple Sclerosis
Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Clinical and experimental evidences suggests an immunomodulatory effect of sex hormones in multiple sclerosis. The role of oral estroprogestins in the pathogenesis and in the clinical course of the disease is actually unknown.
- Trial name
- NCT00151801
- Testing
- estroprogestins, interferon-beta 1a
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- S. Andrea Hospital
Asthma
Effect of Sex Hormone During the Menstrual Cycle on Capsaicin Evoked Cough Responses
The study aim is to investigate if changes in sex hormones during the menstrual cycle affects cough sensitivity in females and males with mild allergic asthma.
- Trial name
- CASH (NCT04233762)
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McMaster University
Transsexualism, Transgenderism
Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System
Current study aims to characterize five highly interconnected physiological systems in patients undergoing cross-sex hormone therapy - namely glucose and lipid metabolism, energy balance, eating behavior, functional brain…
- Conditions
- Transsexualism, Transgenderism, Adiposity, Eating Behavior
- Trial name
- HHS (NCT04838249)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Females, Menstrual Discomfort
Integrated Exercise Approach Strength Postural Stability Menstrual Cycle Biomarkers Eumenorrheic Females
The study will determine the effects of integrated exercise approach on strength, postural stability and biomarkers (estrogen, progesterone and testosterone) of menstrual cycle in eumenorrheic females and translation of Unified…
- Trial name
- NCT05460741
- Testing
- integrated exercise approach, educational program
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development