Clinical trials: Gonadotropins
Hypogonadism, Precocious Puberty
Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II.
- Trial name
- NCT00004335
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Prostate Cancer
Study to Evaluate a Subcutaneous Four Months Sustained-release Formulation of Triptorelin in Patients With Prostate Cancer
To identify the proportion of patients remaining medically castrated (testosterone level < 50 ng/dL) on Day 240 following two administrations of a 4-month sustained-release (SR) formulation of triptorelin.
- Trial name
- NCT00415246
- Testing
- Triptorelin (Decapeptyl®) - Treatment 8 months (pivotal study) followed by a treatment extension of 8 months (extension study)
- Where
- 31 sites in Belgium, France and 6 more
- Volunteers
- 100 people
- Sponsor
- Ipsen
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Preterm Labor
HUMAN CHORIONIC GONADOTROPIN (HcG) VS MAGNESIUM SULPHATE (MgSo4) AS A TOCOLYTIC AGENT- A RANDOMIZED CONTROLLED TRIAL
Preterm labor is defined as regular contractions of the uterus resulting in changes in the cervix (effacement and dilatation) that start before 37 weeks of pregnancy.
- Trial name
- NCT05828966
- Testing
- human chorionic gonadotropin (hCG), Magnesium sulfate
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Healthy
Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Men
This is a prospective, randomized, double-blinded, two-center trial to evaluate the gonadotropin suppressive activity of transdermal treatment with a combined NES/T gel, or T gel alone, for 28 days.
- Trial name
- NCT02432261
- Testing
- Nestorone® /testosterone gel, Testosterone only gel
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Female Infertility
Addition of Gonadotropin Releasing Hormone Agonist to Luteal Phase Support
Hormonal milieu during implantation is crucial to embryo-endometrium interaction and to the viability of the conceptus. Alterations in the peri-implantation environment are considered to impair perinatal outcomes in…
- Trial name
- NCT05286554
- Testing
- gonadotropin releasing hormone-agonist, Progesterone
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Alexandria University
Infertility, Female
Retrospective Analysis of Real-world Data From Medical Records on the Use of MENOPUR for Infertility Treatment
The purpose of this retrospective observational study is to describe the treatment patterns with MENOPUR and to understand the clinical impact for patients that underwent infertility treatment under real-world setting.
- Trial name
- NCT04814940
- Testing
- MENOPUR Cohort
- Where
- Israel
- Sponsor
- Ferring Pharmaceuticals
Ovarian Response
Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients
There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging.
- Trial name
- APPE (NCT00870025)
- Testing
- human chorionic gonadotropin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- IVI Madrid
Anovulation, Infertility
Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility
Ovulation disorders are a common cause of infertility in women. Most of these women can be classified as World Health Organization (WHO) Group II anovulatory patients as they have irregular or absent menstrual cycles but normal…
- Trial name
- NCT01250821
- Testing
- Menopur
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Medical Abortion
Does Follow-up With Serum Beta Human Chorionic Gonadotropin (BhCG) Simplify Medical Abortion?
The purpose of this study is to evaluate if BhCG testing to determine the completion of medical abortion simplifies the medical abortion protocol.
- Trial name
- NCT00907725
- Testing
- serum BhCG follow-up, ultrasonographic follow-up
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Planned Parenthood League of Massachusetts
Fertility Preservation, Lymphoma
AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility.
- Conditions
- Fertility Preservation, Lymphoma, Pediatrics Cancer, Gonadotropin-releasing Hormone Agonist
- Trial name
- CHANCE (NCT02595255)
- Testing
- No intervention
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Erasme University Hospital
Hydatidiform Mole, Gestational Trophoblastic Neoplasia
Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule
The purpose of present study is to provide clinical evidences for the appropriate management of molar pregnancy with lung nodule. The hydatidiform mole patients with lung nodule ≥1.0cm will be randomized into 2 groups: A.
- Trial name
- NCT03785574
- Testing
- Follow up, chemotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Fibroids
Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy
Rationale: Laparoscopic myomectomy is increasingly performed over laparotomic myomectomy, because of the many benefits for the patient in terms of pain, hospital stay and recovery.
- Trial name
- MYOMEX (NCT02288130)
- Testing
- GnRHa, Ulipristal
- Where
- 9 sites in Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Endometriosis
A Randomized Open Label Study of KLH-2109 in Patients With Endometriosis(1)
The purpose of this study is to evaluate the efficacy and safety of KLH-2109 in patients with endometriosis.
- Trial name
- NCT01395940
- Testing
- KLH-2109
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Polycystic Ovary Syndrome, Infertility
Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) patients are often accompanied by infertility. Non-obese PCOS infertility is more difficult to treat than obese PCOS.
- Conditions
- Polycystic Ovary Syndrome, Infertility, Ovulation Disorder
- Trial name
- NCT03989024
- Testing
- Gonadorelin, Clomiphene
- Where
- China
- Volunteers
- 78 people
- Sponsor
- RenJi Hospital
Infertility
Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Embryo Transfer on Pregnancy Outcomes in Frozen Embryo Transfer Cycles.
The present study is designed as a pilot study with 50 patients in each group. Data collection form will be filled by the researcher who does not know the type of intervention in each group
- Trial name
- NCT02825108
- Testing
- Intra uterine injection of tissue culture medium containing HCG+ET, Intra uterine injection of tissue culture medium +ET, ET
- Where
- Iran
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Threatened Miscarriage, Early Pregnancy Bleeding
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriage
This randomized controlled trial aims to compare the efficacy of Dydrogesterone alone versus Dydrogesterone combined with human chorionic gonadotrophin (HCG) in the treatment of threatened miscarriage in first trimester…
- Trial name
- DYD-HCG (NCT07608133)
- Testing
- Dydrogesterone, Human chorionic gonadotrophin (hCG)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Infertility
GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles
Evaluation of the effect of adding a single dose of gonadotropin releasing hormone agonist (GnRHa) as a luteal phase support on the outcomes of intracytoplasmic sperm injection (ICSI) following long GnRHa protocol
- Trial name
- NCT02312076
- Testing
- Triptorelin
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Pedophilia
Comparison of Two Pharmacological Treatments of Pedophilia
Sexual abuse committed on children is a major public health problem because of its frequency and its severe consequences on the mental health of victims.
- Trial name
- PCNET (NCT00601276)
- Testing
- leuprorelin, Cyproterone acetate
- Where
- 4 sites in France
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France