Clinical trials: Gonarthrosis; Primary
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP)
This is a multi-phase study that will develop and test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening…
- Trial name
- NCT03780400
- Testing
- Osteoarthritis Physical Activity Care Pathway
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis, Hip Osteoarthritis
Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to…
- Trial name
- NCT03838874
- Testing
- Low-Dose Bupivacaine, Mepivacaine
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Predicting Poor Outcomes After Primary Knee Arthroplasty
Aim To identify through data analysis key patients, surgeon and operative dependent variables which will improve the performance of knee replacement for primary osteoarthritis Research Question 1.
- Trial name
- NCT01765699
- Testing
- Primary knee arthroplasty
- Volunteers
- 1,300 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Osteoarthritis, Knee
Does Electrocautery Increase Postoperative Pain in Primary Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a successful treatment for end-stage osteoarthritis of the knee. The main advantages of TKA are to relieve the pain of the knee, improve the knee function, restore lower limb alignment, and…
- Trial name
- NCT06239038
- Testing
- total knee arthroplasty
- Where
- Thailand
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Police General Hospital, Thailand
Knee Osteoarthritis, Multimorbidity
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.
- Trial name
- NCT07882316
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Balikesir Ataturk City Hospital
Unilateral Primary Osteoarthritis of Knee
Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty
Osteoarthritis is a progressive disease afflicting to two thirds of Americans. Today, an estimated 43 million individuals have arthritis. By 2020, more than 59.4 million Americans will be affected by the disease.
- Trial name
- NCT01764984
- Testing
- Total knee arthroplasty
- Where
- 3 sites in Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Knee Arthritis Osteoarthritis
Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance
The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided.
- Trial name
- PRECISION-Knee (NCT07544576)
- Testing
- Triamcinolone knee injection without ultrasound guidance, Triamcinolone knee injection with ultrasound guidance
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sosi Dzhugarian
Osteoarthritis of the Knee
MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty
Overall study design: A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system.
- Trial name
- MIS GEN II (NCT00853398)
- Testing
- surgical technique
- Where
- Germany
- Sponsor
- Smith & Nephew Orthopaedics AG
Primary Osteoarthritis
Effect of Zoledronic Acid in Primary Knee Osteoarthritis
We try to find out the effect of zoledronic acid over pain of primary knee osteoarthritis and also functional status in a period of 6 months.
- Trial name
- NCT06051344
- Testing
- Zoledronic acid
- Where
- Bangladesh
- Volunteers
- 92 people
- Sponsor
- Toufiqe-E-Ealahi
Osteoarthritis, Knee
Patient-Specific Versus Conventional Instrumentation in TKA
The aim of this prospective multicenter randomized clinical trial (RCT) is to compare the clinical and radiologic results of primary total knee arthroplasty (TKA) using patient-specific versus conventional instrumentation.
- Trial name
- Visio (NCT02002624)
- Testing
- PSI, Conventional instrumentation
- Volunteers
- 140 people
- Sponsor
- Cochin Hospital
Osteoarthritis of the Knee
Clinical and Stereoradiological Comparison of the Results After Primary Cemented Total Knee Arthroplasty Inserted With or Without the Use of a Tourniquet
The purpose of this study is to investigate if the use of a tourniquet during insertion of a cemented primary total knee arthroplasty will influence clinical and radiological (measured with RSA X-ray technique) outcome.
- Trial name
- NCT01488175
- Testing
- tourniquet, no tourniquet
- Where
- Denmark
- Sponsor
- Hvidovre University Hospital
Knee Osteoarthritis
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee…
- Trial name
- NCT02863120
- Testing
- liposomal bupivacaine, bupivacaine HCl, Ropivacaine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Texas Orthopaedics, Sports and Rehabilitation Associates
Primary Knee Osteoarthritis
Comparison of the Effectiveness of High-Intensity and Low-Intensity Laser Therapies in Primary Knee Osteoarthritis
Our primary goal is to investigate the advantages of low-intensity laser therapy (LLLT) and high-intensity laser therapy (HILT) over conventional therapy in patients with knee osteoarthritis (OA), our secondary goal is to…
- Trial name
- NCT06825767
- Testing
- Conventional Treatment, conventional treatment and high-intensity laser therapy(HILT), conventional treatment and low-intensity laser therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Osteoarthritis, Knee
Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty
The purpose of the study is to evaluate the efficacy of local infiltration of liposomal bupivacaine versus use of an indwelling femoral peripheral nerve block in controlling early postoperative pain in primary total knee…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Arthritis, Degenerative, Osteoarthrosis
- Trial name
- NCT02341079
- Testing
- Bupivacaine Liposome Injection, Indwelling femoral nerve block
- Where
- United States
- Sponsor
- United States Naval Medical Center, San Diego
Knee Osteoarthritis, Chronic Pain
Motor Cortex Plasticity and the Effect of Deep Intramuscular Needling Stimulation Therapy (DIMST) in Osteoarthritis Pain
The aim of this study is to evaluate the cortical excitability in pain of knee osteoarthritis (OA), as well as the effect of one session of a kind of electroacupuncture (deep needling intramuscular stimulation therapy - DIMST) in…
- Trial name
- NCT01855958
- Testing
- DIMST
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Knee Osteoarthritis
Comparison of the Efficacy, Tolerability and Safety of actiTENS to Those of Level 2 Analgesic Treatments.
This is a phase 3, multicentre, prospective, single-blind on principal efficacy criterion, 2 parallel groups, randomized, controlled clinical study comparing efficacy and safety of actiTENS versus systemic level 2 analgesics…
- Trial name
- ArthroTENS (NCT03902340)
- Testing
- ActiTENS, Level 2 Analgesic Treatments
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Sublimed
Mobile Application Actuated Rehabilitation Exercise Guidance, Routine Rehabilitation Exercise Guidance
Comparison of the Accuracy in Rehabilitation Exercise Between Mobile Application Actuated Rehabilitation Exercise Guidance and Routine Rehabilitation Exercise Guidance for the Primary Osteoarthritis Knee Patients
Evaluate the accuracy of physical therapy in various positions after 4 weeks of training, comparison of the accuracy in rehabilitation exercise between mobile application actuated rehabilitation exercise guidance and routine…
- Trial name
- NCT03666585
- Testing
- mobile application actuated rehabilitation exercise guidance, routine rehabilitation exercise guidance
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Navamindradhiraj University
Total Knee Arthroplasty
Performance and Safety Evaluation of the FHK®-CK Knee Prosthesis
The life expectancy worldwide is increasing and leading to an increase of knee arthroplasty. Also, as millions of people around the world are currently living with a Total Knee Arthroplasty (TKA), the need for revision surgery…
- Trial name
- FHK-CK (NCT06124482)
- Testing
- Total Knee arthroplasty
- Where
- 7 sites in France
- Volunteers
- 92 people
- Sponsor
- FH ORTHO
Knee Osteoarthritis
Population Pharmacokinetics of Ropivacaine
The aim of this study was to investigate the pharmacokinetics of free and total ropivacaine after unilateral and bilateral TKA. A population model was successfully built and peak free ropivacaine concentration stayed below…
- Trial name
- NCT04702282
- Testing
- ropivacain concentration measurements
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Knee Osteoarthritis
Pilot Trial to Assess the Feasibility of Implementing Objective Parameters in Patients Affected by Knee Osteoarthritis
Pilot, open non-controlled trial to assess the feasibility of implementing objective parameters as primary endpoints in a clinical trial with patients affected by knee osteoarthritis.
- Trial name
- SMILE (NCT03421054)
- Testing
- patients assuming nutraceutical containing HA
- Where
- Romania
- Volunteers
- 8 people
- Sponsor
- River Pharma S.r.l.