Clinical trials: Gonarthrosis; Primary
Osteoarthritis Knee
Mesenchymal Stem Cell Treatment for Primary Osteoarthritis Knee
The purpose of this study is to evaluate the safety and preliminary efficacy of autologous adipose-derived mesenchymal stem cells (ADMSCs) treatment for patients with primary osteoarthritis knee.
- Trial name
- NCT02544802
- Testing
- Adipose-Derived Mesenchymal Stem Cells
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Steminent Biotherapeutics Inc.
Osteo Arthritis Knee
Prospective Observational Study of Pain Evolution in Patients With Primary Knee Osteoarthritis Treated With Pronolis® HD
Prospective observational study of 6 months of follow-up, of national and multicenter scope with medical device with CE marking and according to the usual clinical practice.
- Trial name
- NO-DOLOR (NCT04196764)
- Where
- Spain
- Volunteers
- 188 people
- Sponsor
- Procare Health Iberia S.L.
Osteoarthritis, Knee, Osteoarthritis, Hip
Physiotherapist Led Triage in Primary Care for Patients With Hip or Knee OA
The overall aim with the study is to evaluate physiotherapist led triage in primary care compared to usual care (assessment by an orthopaedic surgeon in an orthopaedic department) for patients with hip or knee osteoarthritis…
- Trial name
- NCT06187116
- Testing
- Physiotherapist consultation, Orthopaedic surgeon consultation
- Volunteers
- 276 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
Introduction: The current evidence on the efficacy of Antibiotic Loaded Bone Cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient.
- Trial name
- ALBA (NCT04135170)
- Testing
- ALBC vs plain bone cement
- Where
- Norway
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- The Norwegian Arthroplasty Register
Osteoarthritis, Knee
A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care
Background: Almost half of the Swedish population are overweight or obese. This will probably affect the incidence of osteoarthritis since overweight is a strong risk factor.
- Trial name
- NCT03822533
- Testing
- Physiotherapist as primary assessor, Physician as primary assessor
- Where
- 9 sites in Sweden
- Volunteers
- 363 people
- Sponsor
- Vastra Gotaland Region
Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty
Drain Removal Before Versus After CPM in Primary Total Knee Arthroplasty
The aim of this prospective randomized controlled study was to determine whether the timing of drain removal in relation to continuous passive motion (CPM) application influences postoperative residual hematoma formation…
- Conditions
- Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty, Postoperative Hematoma
- Trial name
- NCT07302724
- Testing
- Drain Removal Before CPM, Drain Removal After CPM
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Ankara Etlik City Hospital
Unilateral Primary Osteoarthritis of Knee
Assessment of Recovery After Adductor Canal Block Analgesia in Unilateral Prosthetic Knee Surgery
The purpose of the study is post-operative recovery from prosthetic knee surgery will be assessed by the proportion of patients entering the Accelerated Rehabilitation After Surgery program eligible for discharge from hospital at…
- Trial name
- IPACKNEE (NCT05715645)
- Testing
- Unilateral prosthetic knee surgery, Analgesia
- Where
- France
- Volunteers
- 130 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis
Risk Assessment and Management Program (RAMP) on Knee Osteoarthritis in Primary Care
The goal of this clinical trial is to determine the clinical effectiveness of a Chronic Care Model (CCM) named Risk Assessment and Management Program on Knee OA (RAMP-Knee OA) in adults with knee Osteoarthritis (Knee OA) at 52…
- Trial name
- NCT06283147
- Testing
- Risk assessment and Management Programme - Knee Osteoarthritis
- Where
- Hong Kong
- Volunteers
- 228 people
- Sponsor
- Chinese University of Hong Kong
Gonarthrosis; Primary, Gonarthrosis
Comparison of Multiradius and Singleradius Total Knee Arthroplasty
The Investigators would like to compare multiradius and single-radius total knee arthroplasty using with association between sagittal patellar offset and anterior knee pain in subjects having undergone bilateral total knee…
- Conditions
- Gonarthrosis; Primary, Gonarthrosis, Gonarthrosis; Primary, Bilateral, Knee Osteoarthritis
- Trial name
- NCT04364971
- Testing
- singleradius and multiradius total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 494 people
- Sponsor
- Bezmialem Vakif University
Arthroplasty Complications, Infection
Persona Revision Knee System Outcomes
The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment.
- Conditions
- Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
- Trial name
- NCT04821154
- Testing
- Persona Revision Knee System
- Where
- 16 sites in United States
- Volunteers
- 380 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis
To evaluate the clinical efficacy and safety of dental pulp mesenchymal stem cells in the treatment of primary mild to moderate knee osteoarthritis through a comparative study with sodium hyaluronate.
- Trial name
- NCT04130100
- Testing
- Low Dose of Mesenchymal stem cell, High Dose of Mesenchymal stem cell, Sodium Hyaluronate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
Knee Osteoarthritis
A Reliability and Validity Study of Urdu Version of Western Ontario And MacMaster Osteoarthritis Index
The aim of the study is to translate and culturally adapt Western Ontario And MacMaster Osteoarthritis Index into Urdu language and to investigate its reliability and validity Pakistani population with primary knee osteoarthritis…
- Trial name
- NCT05449236
- Where
- Pakistan
- Volunteers
- 87 people
- Sponsor
- Riphah International University
Primary Knee Osteoarthritis
Safety and Efficacy of Sahasthara ME vs Diclofenac ME for Treating Primary Knee Osteoarthritis
Background: Sahasthara is a traditional Thai herbal remedy used for the anti-inflammatory treatment of the musculoskeletal system, while diclofenac sodium is one of the most topically administered anti-inflammatory drug.
- Trial name
- NCT06184685
- Testing
- Sahasthara Microemulsion, Diclofenac Microemulsion
- Where
- Thailand
- Volunteers
- 87 people
- Sponsor
- Thammasat University
Gonarthrosis; Primary, Varus Gonarthrosis
Safety of Bilateral HTO: One-Stage vs.Two-Stage: A Randomized Controlled Study
In this study, bilateral simultaneous high tibial osteotomy (HTO) was compared with staged bilateral HTO in terms of complications.
- Trial name
- NCT04399304
- Testing
- simultaneous bilateral high tibial osteotomy, Staged bilateral high tibial osteotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Bezmialem Vakif University
Osteoarthritis Of Knee
Trial to Assess the Structural Effect and Long-term Symptomatic Relief of Intra-articular Injections of Hyaluronic Acid in Primary Knee OA
The present study is designed to test the hypothesis that Intra-Articular Hyaluronic Acid (IAHA) is superior to placebo in slowing structural progression and on long term symptomatic effect in primary knee Osteoarthritis (OA)…
- Trial name
- ViscOA (NCT02280538)
- Testing
- Intra-Articular Hyaluronic Acid
- Where
- 2 sites in Portugal
- Volunteers
- 300 people
- Sponsor
- Universidade Nova de Lisboa
Knee Osteoarthritis, Musculoskeletal Disease
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving…
- Conditions
- Knee Osteoarthritis, Musculoskeletal Disease, Surgery
- Trial name
- TKACSI (NCT07151417)
- Testing
- PAI, PAI + steroid, PAI + zilretta
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Walter Reed National Military Medical Center
Osteoarthritis, Knee
Fenugreek Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of fenugreek wraps in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- BoGon (NCT03528824)
- Testing
- Fenugreek wrap, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Osteoarthritis, Knee
A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS
The purpose of this study is to determine whether intra-articular (knee joint) administration of MEN16132 is effective reducing the pain from knee osteoarthritis.
- Trial name
- ALBATROSS (NCT01091116)
- Testing
- MEN16132 - 0.125 mg, MEN16132 - 0.25 mg, MEN16132 - 0.5 mg
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 423 people
- Sponsor
- Menarini Group
Osteo Arthritis of the Knee, Synovitis of Knee
Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA
Background: Osteoarthritis (OA) is a leading cause of disability worldwide, with limited treatment options and many patients suffering from chronic pain.
- Conditions
- Osteo Arthritis of the Knee, Synovitis of Knee, Methotrexate
- Trial name
- MTX in knee OA (NCT07161336)
- Testing
- Methotrexate (MTX)
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Osteoarthritis, Knee
Predicting Poor Outcomes After Primary Knee Arthroplasty
Aim To identify through data analysis key patients, surgeon and operative dependent variables which will improve the performance of knee replacement for primary osteoarthritis Research Question 1.
- Trial name
- NCT01765699
- Testing
- Primary knee arthroplasty
- Volunteers
- 1,300 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust