Clinical trials: Gonarthrosis
Knee Osteoarthritis
Grip on Knee Osteoarthritis; DIstraction Versus Arthroplasty
The goal of this pragmatic, open, (1:1) randomized, multi-centre, non-inferiority trial is to to determine whether knee-joint distraction (KD) is non-inferior on patient reported effectiveness as compared to a knee-prosthesis…
- Trial name
- GODIVA (NCT06113549)
- Testing
- Knee Joint Distraction (KD), Knee Prosthesis
- Volunteers
- 600 people
- Sponsor
- UMC Utrecht
Knee Osteoarthritis
Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT02187549
- Testing
- HYMOVIS
- Where
- 21 sites in United States
- Volunteers
- 332 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis
A Study to Access the Efficacy and Safety of Meloxicam in Patients With Osteoarthritis of the Knee
To Access the Efficacy and Safety of Meloxicam 7.5mg once daily over a treatment period of 56 days
- Trial name
- NCT02183116
- Testing
- Meloxicam
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Knee Osteoarthritis
Comparison of the Effect of Genicular Nerve Block and Physical Therapy in Patients With Knee Osteoarthritis
Knee arthritis is a chronic joint disease that causes pain, disability and impaired quality of life, leading to significant social and health problems worldwide.
- Trial name
- NCT06903936
- Testing
- Group 1: GNB (GENICULAR NERVOUS NERVOUS BLOCK) group:, Group 2: PT (PHYSICAL THERAPY) group, Group 3: Exercise group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Knee Osteoarthritis
Remote Tai Chi for Knee Osteoarthritis
The goal of this pragmatic randomized trial is to evaluate the effectiveness of remote Tai Chi to treat knee pain in adults with knee osteoarthritis.
- Trial name
- TAICHIKNEE (NCT06384898)
- Testing
- Remote Tai Chi
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Tufts Medical Center
Arthroplasty, Bone Morphing
Is It Possible to Obtain Reliable MPTA and LDFA Values Using Imageless Navigation in Total Knee Arthroplasty? Comparison Between Preoperative CT Scan Measurements and Intraoperative Bone Morphing Before and After Articular Cartilage Removal
Title: Evaluation of Image-less Navigation Accuracy in Total Knee Arthroplasty (CARNAVAL) Summary: The purpose of this study is to evaluate the accuracy of an imageless navigation system in measuring key anatomical angles (MPTA…
- Conditions
- Arthroplasty, Bone Morphing, Knee Osteoarthritis
- Trial name
- CAR-NAV-AL (NCT07574775)
- Testing
- Non-image-based Computer-Assisted Navigation with Bone Morphing
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Knee Osteoarthritis
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
The purpose of this study is to compare the clinical and functional outcomes of patients with mild to moderate arthroscopically confirmed osteoarthritis between the following two groups: 1.
- Trial name
- NCT03014401
- Testing
- Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis
Dose-Escalation of Botulinum Toxin in Subjects With Osteoarthritis of the Knee
The purpose of the study is to evaluate the safety and tolerability of the drug product at each dose level.
- Trial name
- NCT02139319
- Testing
- Botulinum toxin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Galderma R&D
Knee Osteoarthritis
To Compare the Effect of Closed Kinetic Chain and Isometric Exercises in Reducing Pain and Improving Functional Disability in Patients With Patellofemoral Pain Syndrome Associated With Knee Osteoarthritis
Investigator study aims to compare the benefits of isometric exercise and closed kinetic chain exercises in strengthening programs to lessen pain along with enhance functionality in patients with PFP that are being associated…
- Trial name
- NCT07298798
- Testing
- Terminal knee extension. .VMO squat. [TheraBand], Isometric exercises [knee roller]
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Dow University of Health Sciences
Knee Osteoarthritis
The Effect of Remote Ischemic Preconditioning on Postoperative Cognitive Dysfunction in Total Knee Replacement
The patients were allocated randomly to receive remote preconditioning group (RIPC group, R) or not (Control group, C) using sealed envelopes with the options inside the sealed envelope of R and C before anaesthesia induction.
- Trial name
- NCT02478216
- Testing
- Remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Konkuk University Medical Center
Knee Osteoarthritis (OA), Total Knee Anthroplasty
Tourniquet Vs. No-Tourniquet Technique in Total Knee Arthroplasty at the University Hospital of the West Indies
The goal of this clinical trial is to determine whether performing total knee replacement surgery (total knee arthroplasty, TKA) without a tourniquet is clinically equivalent to performing the procedure with a tourniquet in…
- Trial name
- NCT07506434
- Testing
- pneumatic tourniquet
- Where
- Jamaica
- Volunteers
- 30 people
- Sponsor
- The University of The West Indies
Knee Osteoarthritis
SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS
Joint mobilization and resistance exercise training are effective conservative treatment options for the management of osteoarthritis.
- Trial name
- NCT06444932
- Testing
- Joint Mobilization, Resistance Exercise Training, Transcutaneous Electric Nerve Stimulation (TENS)
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Knee Osteoarthritis
Clinical Trial of Autologous Adipose Tissue-Derived Mesenchymal Progenitor Cells (MPCs) Therapy for Knee Osteoarthritis
Current medication treatments for KOA aim to relieve inflammation and pain, but they do little to delay or reverse the disease progression and most medications have obvious side effects.
- Trial name
- NCT02162693
- Testing
- Mesenchymal progenitor cells, Sodium Hyaluronate
- Where
- 2 sites in China
- Volunteers
- 53 people
- Sponsor
- Shanghai AbelZeta Ltd.
Hip Osteoarthritis, Knee Osteoarthritis
Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis
This pilot RCT study is to examine the comparative effectiveness of two decision aids for hip and knee osteoarthritis.
- Trial name
- NCT02625402
- Testing
- Brief interactive decision aid, Long video decision aid
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis
Platelet-Rich Plasma, Hyaluronic Acid, or Their Combination for Knee Osteoarthritis in Athletes
The goal of this clinical trial is to learn whether a single knee injection of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) works better than PRP alone or HA alone to relieve pain and improve function in…
- Trial name
- NCT07901153
- Testing
- Leukocyte-Poor Platelet-Rich Plasma, Cross-Linked Hyaluronic Acid
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo General Hospital
Mytocel MSK With AMT
A Comparison of Clinical Efficacy of Mytocel MSK With AMT and PRP Injections in Patients With Knee Osteoarthritis
Osteoarthritis is the most common joint disease, frequently affecting the knee joint. As the cartilage within the joint wears down, the balance between degeneration and regeneration is gradually disrupted, causing pain during…
- Trial name
- NCT07453953
- Testing
- PRP
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Knee Osteoarthritis, Widespread Chronic Pain
Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis
The goal is to evaluate whether the number of pain sites or pain estimation with Instant and Constant Osteoarthritis Pain (ICOAP) is related to functional impairment in the lower extremity in people with knee osteoarthritis…
- Trial name
- NCT06854237
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Vastra Gotaland Region
Severe Osteoarthritis of the Knee
Open Label Extension to Assess the Safety of Long-Term Treatment With Ampion for Severe Osteoarthritis (OA) of the Knee
This Open Label Extension (OLE) study will assess the safety of long-term treatment with a 4 mL intra-articular injection of Ampion™ in adults with pain due to severe osteoarthritis of the knee
- Trial name
- NCT03349645
- Testing
- 4 mL injection of AMPION™
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Osteoarthritis
Study on the Use of a Concentrated Growth Factor Preparation Kit for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to evaluate the effectiveness and safety of an autologous platelet-rich concentrated growth factor (CGF) preparation kit for the treatment of knee osteoarthritis in patients diagnosed with this…
- Trial name
- NCT06869200
- Testing
- Concentrated Growth Factor (CGF) Intra-articular Injection, Platelet-Rich Plasma (PRP) Intra-articular Injection
- Where
- 3 sites in China
- Volunteers
- 104 people
- Sponsor
- Guangdong Hongzhi Health Technology
Gonarthrosis, Antioxidative Stress
Effects of Physical Therapy on Oxidative Stress in Female Patients With Gonarthrosis
This study aimed to investigate the production of reactive oxygen derivatives (ROS) and reactive nitrogen derivatives (RNT) in female patients with knee OA, and their effects on oxidative stress by evaluating before and after…
- Trial name
- NCT05731011
- Testing
- antioxidative stress, electrotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Baskent University