Clinical trials: Gout, open to volunteers
Hyperuricemia With or Without Gout
Tart Cherry Citrate Effervescent Tablet for Urate-Lowering Therapy in Participants With Asymptomatic Hyperuricemia
The goal of this clinical trial is to learn whether tart cherry citrate effervescent tablets can lower uric acid levels in people with asymptomatic hyperuricemia (high uric acid levels without gout symptoms).
- Trial name
- TaCCi-HUA (NCT07613138)
- Testing
- tart cherry citrate effervescent table
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Beijing Zhecheng Biotechnology Co., Ltd.
Gout
Immediate Prescription of a Hypouricemic Treatment, Febuxostat, Compared to Its Delayed Administration
Gout, the most common inflammatory rheumatism in France, is a complication of chronic hyperuricemia (> 360umol / l). The resulting urate crystals are deposited in many tissues, especially the skeletal or kidneys.
- Trial name
- FEFACRIGOU (NCT05109936)
- Testing
- Adenuric
- Where
- 6 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Rouen
Gout Flare
24-Week Recurrence Rate of Gout Following Firsekibart Treatment
Study Objective: To evaluate the 24-week recurrence rate and safety of Firsekibart in patients with acute gouty arthritis in a real-world clinical setting.
- Trial name
- NCT07625514
- Testing
- Firsekibart
- Where
- 11 sites in China
- Volunteers
- 264 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gout Flares
Efficacy and Safety of Scheduled Versus As-Needed Firsekibart Administration for the Prevention of Gout Recurrence: A Multicenter, Open-Label, Randomized Controlled Trial
Study Objective To compare the efficacy of continued scheduled dosing versus as-needed dosing in patients with acute gouty arthritis who remained recurrence-free after 24 weeks of treatment with Firsekibart.
- Trial name
- NCT07616531
- Testing
- Scheduled Firsekibart administration, As-Needed Firsekibart Administration
- Where
- 11 sites in China
- Volunteers
- 118 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyperuricemia, Gout
Probiotic-Uricase Complex Preparation for Improving Uric Acid Metabolism in Patients With Hyperuricemia
This single-center, open-label, two-arm interventional study aims to evaluate the efficacy and safety of a probiotic-uricase complex preparation in patients with hyperuricemia.
- Trial name
- NCT07613164
- Testing
- Probiotic-uricase complex preparation
- Volunteers
- 45 people
- Sponsor
- Maanshan Shiqiye Hospital
Gout
The Remote Monitoring of Gout Feasibility Study in Primary Care
The goal of this feasibility study is to determine the feasibility of a patient self-management app (MinUrinsyregikt) for patients with gout. The primary objectives of the study are: 1.
- Trial name
- ReMonit Gout (NCT07490522)
- Testing
- Patient self-management app 'MinUrinsyregikt'
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Diakonhjemmet Hospital
Gout, Uric Acid
the Effects of Febuxostat Dose Tapering in Gout Patients Optimally Controlled for 5 Years or More
The goal of this clinical trial is to compare the changes in serum urate levels and symptom recurrence after reducing or suspending urate-lowering agents in well-controlled gout patients (the 'after dishes are clean' state in the…
- Trial name
- TARGET (NCT06622603)
- Testing
- Febuxostat
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Seoul National University Hospital
Gout Chronic, Gout
Drug-Drug Interaction Study of ABP-671 in Gout Patients
This is a open-Label, Within-Subject Drug-Drug Interaction Study of ABP-671 Added to Stable Allopurinol Therapy in Gout Patients.
- Conditions
- Gout Chronic, Gout, DDI (Drug-Drug Interaction)
- Trial name
- NCT07367971
- Testing
- ABP-671 plus allopurinol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Atom Therapeutics Co., Ltd
Primary Gout and Hyperuricemia
The Efficacy and Safety of SHR4640 Tablet Combined With 40 mg Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia
SHR4640 tablets is a highly selective and potent URAT1 inhibitors. The study is being conducted to evaluate the efficacy, and safety of SHR4640 tablet combined with 40 mg/d febuxostat tablet in reducing uric acid in subjects with…
- Trial name
- NCT07362355
- Testing
- SHR4640 ；Febuxostat, SHR4640 ; Febuxostat, SHR4640
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Arthritis, Rheumatoid Arthritis (RA)
Dose Response of Exercise for Arthritis Management
The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.
- Conditions
- Arthritis, Rheumatoid Arthritis (RA), Gout, Fibromyalgia (FM)
- Trial name
- DREAM (NCT06880653)
- Testing
- DREAM Adaptive Intervention
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- University of South Carolina
CPPD - Calcium Pyrophosphate Deposition Disease, Gout
The Orienting Study
This study at IRCCS Galeazzi - Sant'Ambrogio Hospital involves patients with gout, CPPD, and osteoarthritis as a control group. Patients will receive routine care with regular clinical, laboratory, and imaging assessments every…
- Trial name
- ORIENTING (NCT07504146)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Hyperuricemia With or Without Gout
The Effects of a Probiotic Food Supplement in Hyperuricaemia
The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid…
- Trial name
- Bugs4U-PoC (NCT07141888)
- Testing
- Probiotics, Probiotics plus fibre
- Where
- Sweden
- Volunteers
- 99 people
- Sponsor
- Örebro University, Sweden
Gout and Hyperuricemia
Clinical Trial of BR2251 Tablets for Patients With Primary Gout and Hyperuricemia
This study is a randomized, double-blind, non-befloxacin-controlled, multicenter, phase II clinical trial, evaluating the efficacy, safety, and pharmacokinetic characteristics of BR2251 tablets when administered multiple times in…
- Trial name
- BR2251-201 (NCT07498647)
- Testing
- BR2251, Febuxostat
- Volunteers
- 160 people
- Sponsor
- BioRay Pharmaceutical Co., Ltd.
Infection, Heart Failure
Home Hospital for Suddenly Ill Adults
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be…
- Conditions
- Infection, Heart Failure, COPD, Asthma
- Trial name
- NCT03524222
- Testing
- Home Hospitalization
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Brigham and Women's Hospital
Acute Gout Flare, Gout Attack
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
The purpose of this trial is to investigate the efficacy and safety of dapansutrile (OLT1177®) tablets in subjects with an acute gout flare.
- Conditions
- Acute Gout Flare, Gout Attack, Gout Flare, Gouty Arthritis
- Trial name
- NCT05658575
- Testing
- Dapansutrile
- Where
- 40 sites in United States, France and 3 more
- Volunteers
- 300 people
- Sponsor
- Olatec Therapeutics, Inc.
Gout
Time Required to Dissolve Urate Deposits
Gout is characterized by episodes of acute arthritis of the lower limbs due to intermittent activation of innate immunity in the joints where urate crystals have formed.
- Trial name
- ReViGoRe 40 (NCT06669000)
- Testing
- Standard X-Rays, Ultrasound, DECT of feet
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis
HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), are rare but life-threatening complications that…
- Conditions
- Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis, Gout and Hyperuricemia
- Trial name
- HLA-SCREEN (NCT07369622)
- Testing
- HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Gout Arthritis, Gout Flare
Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares
This is a randomized, multicenter, double-blind, single administration study to investigate the efficacy and safety of 2 dosing regimens of Purified Cortrophin® Gel in the treatment of an acute gouty arthritis flare.
- Conditions
- Gout Arthritis, Gout Flare, Gout
- Trial name
- NCT07346079
- Testing
- Purified Cortophin Gel, 40 U, Purified Cortophin Gel 80 U
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Gout
Improving Gout Care After an ED Visit
The prevalence of gout has been steadily increasing over several decades and is correlated with the rising burden of obesity, chronic cardiac and renal disease; all conditions overrepresented in the Southeastern U.S.
- Trial name
- CARE-Gout (NCT06534554)
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Gout Disease, Metabolic Diseases
Landscape of Gout in French Polynesia.
The aim of this research is to characterise the genetic and molecular landscape of gout, inflammation and metabolic diseases, as well as the associated molecular, anthropomorphic and pathological characteristics.
- Conditions
- Gout Disease, Metabolic Diseases, Inflammation
- Trial name
- METABOGOUT (NCT07343336)
- Testing
- Epidemiological study, Blood and urine tests
- Where
- 6 sites in French Polynesia
- Volunteers
- 2,750 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University