Clinical trials: Gout, open to volunteers
Gout
A Phase Ib Clinical Trial of Peguricase for Injection With Methotrexate in Patients With Uncontrolled Gout.
To evaluate the safety and tolerability of peguricase for injection with methotrexate in patients with gout who remain uncontrolled after standardized treatment with conventional uric acid-lowering drugs, to determine the…
- Trial name
- NCT06298071
- Testing
- SIBP-R002, Methotrexate
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Institute Of Biological Products
Gout, Obesity
Orlistat and Weight Management for Uric Acid Control in Obese Gout: A RCT
A total of 120 obese gout patients were included in a 24-week double-blind randomized controlled design. The intervention group received orlistat 120 mg tid + UTL + individualized diet-exercise-behavioral reinforcement weight…
- Trial name
- OWMUAC (NCT07326839)
- Testing
- Orlistat 120 mg, Allopurinol 100 up to 600mg/day, Febuxostat 40mg Tab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- XueMei Guo
Gout Arthritis, Cycling
An Exploratory Clinical Study on the Protective Effect of Cycling on the Ankle Joint in Gout
This study divided the enrolled gout patients into a jogging group and a cycling group to investigate 1）the effectiveness of cycling intervention in reducing the recurrence risk of gouty ankle arthritis compared with jogging.
- Conditions
- Gout Arthritis, Cycling, Physical Activity
- Trial name
- NCT07312396
- Testing
- Urate-lowering therapy (ULT), Jogging, Cycling
- Volunteers
- 90 people
- Sponsor
- Zhu Xiaoxia
Hyperuricemia or Gout, Hypertension
Effect of Dotinurad in Hyperuricemia With Hypertension
The effect of dotinurad on CAVI (cardio-ankle vascular index) will be compared with that of febuxostat in patients with hyperuricemia complicated by hypertension.
- Trial name
- DIANA-NEXT (NCT06834230)
- Testing
- Dotinurad, Febuxostat
- Where
- Japan
- Volunteers
- 360 people
- Sponsor
- Saga University
Acute Gouty Arthritis, Gout Flare
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
A randomized, double-blind, international multicenter, colchicine and placebo-controlled study to evaluate the efficacy and safety of ABP-745 in subjects with acute gout.
- Conditions
- Acute Gouty Arthritis, Gout Flare, Gout Flares, Acute Gout Flare
- Trial name
- NCT07145229
- Testing
- ABP-745 Dose A, ABP-745 Dose B, Colchicine
- Where
- 38 sites in United States, Australia and 1 more
- Volunteers
- 380 people
- Sponsor
- Atom Therapeutics Co., Ltd
Gout
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered…
- Trial name
- TRUST (NCT04875702)
- Testing
- Allopurinol, Naproxen 250 MG, Colchicine 0.6 mg
- Where
- 7 sites in United States
- Volunteers
- 650 people
- Sponsor
- Massachusetts General Hospital
Health Literacy, Gout Arthritis
Nurse-Led Telehealth for Gout
The aim of this clinical trial is to evaluate whether nurse-led telehealth support helps individuals with gout better manage their condition and adhere to urate-lowering medication after discharge from a rheumatology clinic.
- Conditions
- Health Literacy, Gout Arthritis, Gout Initiating Urate-loweringUrate-lowering Therapy, Telehealth
- Trial name
- GoutConnect (NCT06971146)
- Testing
- Nurse-Led Self-Management Support, GP-follow up
- Where
- 5 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
The CARe RAiSE project represents a pioneering translational initiative aimed at advancing precision medicine in the treatment of autoimmune rheumatic diseases.
- Conditions
- Rheumatic Diseases, Rheumatoid Arthritis (RA), Giant Cell Arteritis (GCA), Psoriatic Arthritis (PsA)
- Trial name
- CARe RAiSE (NCT07150000)
- Testing
- Ex Vivo Assay
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Hyperuricemia or Gout
Clinical Efficacy Trial of Burdock Root Extract in Patients With Asymptomatic Hyperuricaemia
Multicentre, double-blind, randomized, placebo-controlled trial of the clinical efficacy of burdock root extract in patients with asymptomatic hyperuricemia, with the primary objective to assess the efficacy of the use of burdock…
- Trial name
- NCT07002762
- Testing
- Burdock ( Arctium lappa L.) root extract in a form of a nutritional additive
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- OMNIFARMA LLC
Gout; Hyperuricemia, Gout Flare
Developing A Gout Action Plan in Primary Care Setting in Singapore
The goal of this clinical trial is to develop a gout action plan in primary care setting in Singapore among adult patients with gout, and to learn if the gout action plan can improve gout control.
- Conditions
- Gout; Hyperuricemia, Gout Flare, Gout Chronic
- Trial name
- NCT07061587
- Testing
- Gout action plan
- Where
- Singapore
- Volunteers
- 72 people
- Sponsor
- SingHealth Polyclinics
Gout, Hyperuricemia
Safety, Tolerability, and Pharmacokinetic Characteristics of SSS11 in Patients With Gout and Hyperuricemia
This is a safety, tolerability, pharmacokinetics, and preliminary pharmacological study of multiple administration, dose escalation, randomized double-blind, placebo-controlled.The main purpose of this experiment is to evaluate…
- Trial name
- NCT06629376
- Testing
- Pegylated Recombinant Candida Utilis Uricase for Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Hyperuricemia or Gout, Nephrolithiasis
Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets
To evaluate whether alkalization has the effect of lowering uric acid and reducing gout flare and determine whether alkalization has a role in the prevention and treatment of urinary calculi in gout, the research participants…
- Trial name
- NCT06966635
- Testing
- Sodium Bicarbonate Oral Capsule, Potassium Citrate Tablets, uric-acid-lowering drug
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Huashan Hospital
Gout Chronic
Maintenance or Withdrawal of Urate Lowering Therapy According to Ultrasound Features in Gout Patients: a Randomised Controlled Trial Stop Treatment In Gout
According to international recommendations, urate lowering therapy (ULT), mainly the xanthine oxidase inhibitors (XOIs) allopurinol and febuxostat, should be prescribed lifelong in gout patients.
- Trial name
- STING (NCT06956885)
- Testing
- Discontibuation of oral ULT, Maintenance of ULT
- Volunteers
- 450 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gout Arthritis, Gout Attack
Efficacy Anda Safety of Etoricoxib With Betamethasone for the Treatment of Acute Gout Arthritis
Phase III longitudinal, multicenter, randomized, double-blind clinical trial. The aim of this study is to evaluate the efficacy and safety of the Fixed-Dose Combination of Etoricoxib/Betamethasone Versus Etoricoxib in Patients…
- Trial name
- NCT06863701
- Testing
- Etoricoxib + Betamethasone fixed dose, Etoricoxib fixed dose
- Where
- Mexico
- Volunteers
- 72 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Gout
Prevalence of Abnormalities in Ultrasonography of Joint and Tendons in Patients With Gout
Gout is the most frequent inflammatory arthritis in men after 40 years, with a prevalence of 0.9% in France. This disease is characterized by deposits of sodium urate crystals in joints, tendons and soft tissues, which can be…
- Trial name
- EchoGoutte (NCT05546593)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gout, Rheumatoid Arthritis
Assessment of Physician Consideration of EPRO's, from Patients with Gout, Rheumatoid Arthritis, Sjogren's Syndrome or Systemic Lupus, on the Frequency of Therapeutic Adjustments
Inflammatory rheumatic diseases affect 1% of the population. Treatment of such diseases should be based on disease activity, safety issues and other patient characteristics such as comorbidities (EULAR, 2022), leading to a higher…
- Conditions
- Gout, Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus
- Trial name
- CAPTAIN (NCT05927688)
- Testing
- Therapeutic management following access by the physician to his patient's ePROs
- Where
- France
- Volunteers
- 352 people
- Sponsor
- University Hospital, Strasbourg, France
Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes
Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2
The aim of this study is to investigate the relationship between body fat distribution measured by CT scan and related risk factors with the risk of incident metabolic and cardiovascular disease in a prospective cohort study of…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- OCES-2 (NCT06694012)
- Where
- Japan
- Volunteers
- 2,000 people
- Sponsor
- Osaka Metropolitan University
Refractory Gout
Study on the Efficacy and Safety of Thermotherapy in the Treatment of Refractory Gout
Gout is a crystal-related arthropathy caused by purine metabolism disorder or decreased uric acid excretion. It can manifest as acute recurrent arthritis, tophus formation, tophaceous chronic arthritis, and urate nephropathy…
- Trial name
- NCT06653686
- Testing
- Hyperthermia combined with oral febuxostat., Febuxostat
- Volunteers
- 128 people
- Sponsor
- The First Hospital of Jilin University
Gout, Chondrocalcinosis
CRYSTALILLE Cohort: Getting the Whole Picture of Crystal-related Arthropathies
The objective of this research is to collect data to create an observatory of microcrystalline rheumatism (gout and calcium-crystal rheumatism) in patients treated at the Groupement des Hôpitaux de l'Institut Catholique de Lille…
- Conditions
- Gout, Chondrocalcinosis, Hydroxyapatite
- Trial name
- CRYSTALILLE (NCT04695028)
- Testing
- Data collection
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Lille Catholic University