Clinical trials: Graft -Versus-host-disease
Fecal Microbiota Transplantation in Graft vs. Host Disease
Autologous Fecal Microbiota Transplantation for Patients With Acute Graft-versus-Host Disease
This study aims to assess the safety and efficacy of autologous fecal microbiota transplantation (FMT) in gastrointestinal (GI) related graft-versus-host disease (GVHD).
- Trial name
- NCT03492502
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Wounds
Trial of PICO Versus Standard Care in Chronic and Sub-acute Wounds
Randomised Controlled Trial of PICO (a portable Negative Pressure Wound Therapy) versus standard care in patients with chronic and sub-acute wounds.
- Trial name
- NCT02458859
- Testing
- PICO (single use portable negative pressure wound therapy)
- Where
- 20 sites in Canada, United Kingdom
- Volunteers
- 62 people
- Sponsor
- Smith & Nephew, Inc.
Graft Versus Host Disease
Brentuximab Vedotin in Treating Patients With Steroid-Resistant Acute Graft-Versus-Host Disease
The purpose of this research is to test the safety and efficacy of brentuximab vedotin in patients with acute skin graft-versus-host disease (GVHD)
- Trial name
- NCT01616680
- Testing
- brentuximab vedotin, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Chagas' Disease (Chronic) With Other Organ Involvement
Lower Urinary Tract Dysfunction in Chronic Chagas' Disease : Clinical and Urodynamic Presentation
Chagas disease is one of the most neglected vector-borne infectious disease worldwide. The first decades following the discovery of the pathology drove an international research enthusiasm, mainly concentrated on understanding…
- Trial name
- NCT03189056
- Testing
- Chagas serology, Creatinina, Urodynamic exploration
- Where
- Bolivia
- Volunteers
- 152 people
- Sponsor
- Institut de Recherche pour le Developpement
Chronic Graft vs Host Disease
Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) can be hard to diagnose, difficult to manage and contributes significantly to morbidity and mortality in hematopoietic stem cell transplantation patients.
- Trial name
- ABLE-cGVHD (NCT02067832)
- Where
- 25 sites in United States, Austria and 1 more
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Endocytoscopy
Endocytoscopy of Upper Gastrointestinal Tract in Acute Graft-versus-host Disease: a Pilot Study
The goal of this clinical trial is to test the assess the diagnostic effectiveness of endocytoscopy in patients with underlying UGI aGvHD. The main question it aims to answer is: the effectiveness of ECS for diagnosing UGI aGvHD.
- Trial name
- NCT06247891
- Testing
- ECS Group
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Ruijin Hospital
Pruritus Chronic, Kidney Diseases, Chronic
Anrikefon vs Nalfurafine for Sleep Quality in Hemodialysis Patients With CKD-aP
The goal of this clinical trial is to compare a new intravenous drug, Anruikefen, with a traditional oral medication, nalfurafine orally disintegrating tablets, in improving sleep quality in patients with chronic kidney…
- Conditions
- Pruritus Chronic, Kidney Diseases, Chronic, Renal Insufficiency, Chronic, Uremia; Chronic
- Trial name
- Anrikefon (NCT07380113)
- Testing
- Anrikefon, Nalfurafine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
Chronic, Intractable Back Pain and/or Leg Pain
Clinical Trial of MED HF10™ Spinal Cord Stimulation for the Treatment of Chronic Pain
This is a single-center, prospective, non-randomized exploratory study in subjects with chronic, intractable back pain and/or leg pain per the center's routine practice.
- Trial name
- MED (NCT06897280)
- Testing
- SCS Device Program Setting
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nevro Corp
Hematologic Diseases
Intra Bone Marrow Injection Of Unrelated Cord Blood Cells
Compared to other stemcell sources cord blood (CB) is easier and safer to procure, has no donor attrition, a limitless supply, reduced viral transmission, less acute \& chronic GVHD, is rich in hematopoietic progenitor cells, and…
- Trial name
- CB01 (NCT00696046)
- Testing
- Intrabone Marrow Injection
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Gestational Hypertension, Preeclampsia
App-based Remote Blood Pressure Monitoring
Remote postpartum blood pressure monitoring program with text messages has been shown to increase adherence to recommended postpartum blood pressure checks among those with hypertension at discharge from birth hospitalization…
- Conditions
- Gestational Hypertension, Preeclampsia, Chronic Hypertension Complicating Pregnancy
- Trial name
- NCT05595629
- Testing
- App-based remote blood pressure monitoring, text-message based remote blood pressure monitoring
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Cytomegalovirus Infections, Cytomegalovirus Disease
Letermovir Prophylaxis Duration Guided by CMV-Specific T-cell Monitoring After Allo-HSCT.
The purpose of this study is to evaluate the efficacy and safety of a personalized strategy for discontinuing Letermovir (a drug used to prevent Cytomegalovirus [CMV] infection) based on the recovery of the patient's own immune…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Disease, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease
- Trial name
- NCT07569653
- Testing
- CMV-Specific T-cell Guided Letermovir Discontinuation, Standard Letermovir Prophylaxis
- Where
- 12 sites in China
- Volunteers
- 120 people
- Sponsor
- WeiShi
Hematopoietic Stem Cell Transplantation, Graft Versus Host Disease
Optimization of Antibiotic Treatment in Hematopoietic Stem Cell Receptors
There are data suggesting that the reduction of the diversity of intestinal microbiota caused by the used treatments in the setting of allogeneic hemopoietic stem cell transplant (ASCT), and specially antibiotics, may be related…
- Trial name
- Optimbioma (NCT03727113)
- Testing
- Optimization cohort, Control cohort
- Where
- 5 sites in Spain
- Volunteers
- 211 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Chronic Graft Versus Host Disease cGVHD
Safety and Efficacy of Efavaleukin Alfa in Subjects With Steroid Refractory Chronic Graft Versus Host Disease
Phase 1b: To evaluate the safety and tolerability of multiple ascending doses of efavaleukin alfa in subjects with steroid refractory chronic graft versus host disease (cGVHD).
- Trial name
- NCT03422627
- Testing
- Efavaleukin Alfa
- Where
- 14 sites in United States, Belgium and 2 more
- Volunteers
- 32 people
- Sponsor
- Amgen
Depression, ESRD
Morbidity and Mortality Among Dialysis Patients After Treatment for Depression
Morbidity and Mortality among Dialysis Patients after Treating Depression Objectives Our investigation has two objectives: 1. To assess whether treatment and recovery from depression decreases adverse clinical events in chronic…
- Trial name
- NCT00442429
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Portland VA Medical Center
Graft Versus Host Disease, Stem Cell Transplantation
Voriconazole Pharmacokinetics in Children With Gastrointestinal Graft Versus Host Disease
Determine how much voriconazole is absorbed when the product is given by mouth to children with extensive graft versus host disease after a stem cell transplantation and determine the correct dosing of voriconazole in this…
- Trial name
- NCT00792246
- Testing
- voriconazole
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Phillip Brian Smith
Multiple Myeloma, Leukemia
Cellular Therapy With Cord Blood Cells
The goal of this clinical research study is to learn if giving umbilical cord blood along with standard stem cells after high-dose chemotherapy will improve the response to a stem cell transplant.
- Conditions
- Multiple Myeloma, Leukemia, Lymphoma
- Trial name
- NCT00427557
- Testing
- Fludarabine, Melphalan, Umbilical Cord Blood
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Graft vs Host Disease
Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant
This open-label, single-arm, Phase II multi-center study enrolled 46 participants and investigated the activity, pharmacokinetics and safety of ruxolitinib added to the subject's immunosuppressive regimen among infants, children…
- Trial name
- REACH 5 (NCT03774082)
- Testing
- INC424
- Where
- 21 sites in Brazil, Canada and 12 more
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Chronic graft-versus-host disease (cGvHD) is one of the most serious complications following BMT (Bone Marrow Transplantation). cGvHD occurs when donor immune cells "attack" the tissues and organs of the person receiving the BMT.
- Conditions
- Chronic Graft-versus-Host-Disease, Allogeneic Hematopoietic Stem Cell Transplantation, Leukemia, Blood Cancer
- Trial name
- NCT05692713
- Where
- 10 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of British Columbia
Acute Leukemia, Acute Lymphoblastic Leukemia
Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)
This phase II trial investigates two strategies and how well they work for the reduction of graft versus host disease in patients with acute leukemia or MDS in remission.
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT03970096
- Testing
- Total-Body Irradiation, Thiotepa, Fludarabine
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Lymphocytic Leukemia, Graft vs Host Disease
The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers
Cancers of the blood, sometimes referred to as hematologic malignancies, are disorders of bone marrow cells that lead to the failure of the normal function of bone marrow and the uncontrolled growth of cancerous cells in the bone…
- Conditions
- Chronic Lymphocytic Leukemia, Graft vs Host Disease, Hematologic Neoplasm, Multiple Myeloma
- Trial name
- NCT00001873
- Testing
- Isolex 300i plus MoAbs
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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