Clinical trials: Graft -Versus-host-disease
Chronic Graft Versus Host Disease
Upfront Ruxolitinib for Chronic Graft-vs-host Disease
While hematopoietic stem cell transplant (HSCT) is an effective therapy, graft versus host disease (GVHD) is the most significant complication after HSCT.
- Trial name
- NCT06695507
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
GVHD,Acute
CXCL9 and EASIX for Prediction of Acute Graft Versus Host Disease
The prediction of severe acute GVHD before it occurs is of high importance for ensuing clinical decisions and overall success of allogeneic SCT.
- Trial name
- NCT05718791
- Testing
- blood sample
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Chronic Graft Versus Host Disease
Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
This is an open-label phase I study of fostamatinib in combination with ruxolitinib for the treatment of chronic GvHD with a suboptimal response to corticosteroids.
- Trial name
- NCT06233110
- Testing
- Fostamatinib, Ruxolitinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stefanie Sarantopoulos, MD, PhD.
Graft-versus-host-disease, GVHD
CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease
The purpose of this study is to examine the safety and efficacy of the addition of BMS-986004 to standard of care Sirolimus (SIR)-based immune suppression.
- Conditions
- Graft-versus-host-disease, GVHD, GVHD, Acute
- Trial name
- NCT03605927
- Testing
- BMS-986004, Sirolimus, Tacrolimus
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Graft-versus-host-disease, GVHD
A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD
Bone marrow transplant (BMT) patients can develop graft-versus-host disease (GVHD), a serious and potentially fatal complication.
- Trial name
- NCT03459040
- Testing
- Alpha 1-Antitrypsin
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- John Levine
Acute-graft-versus-host Disease, aGVHD
A Study to Evaluate the Safety, Tolerability, PK, PD, and Clinical Activity of EQ001 in Subjects With aGVHD
This is a multi-center study to evaluate the safety, tolerability, PK, PD, and clinical activity of EQ001 in subjects with Acute Graft Versus Host Disease (aGVHD).
- Conditions
- Acute-graft-versus-host Disease, aGVHD, GVHD, GVHD, Acute
- Trial name
- EQUATE (NCT03763318)
- Testing
- EQ001
- Where
- 16 sites in United States
- Volunteers
- 30 people
- Sponsor
- Biocon Limited
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Graft Versus Host Disease
Romidepsin in Treating Patients With Steroid-Refractory Graft-versus-Host Disease
This pilot clinical trial studies romidepsin in treating patients with graft-versus-host disease (GVHD) that has not responded to treatment with steroids.
- Trial name
- NCT02203578
- Testing
- romidepsin, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rutgers, The State University of New Jersey
Graft vs Host Disease, Bronchiolitis Obliterans
Efficacy Study of Azithromycin-based Therapy for Bronchiolitis Obliterans
[Study Objectives] To evaluate the efficacy of azithromycin, N-acetylcystein, and inhaled corticosteroid combination therapy in patients with bronchiolitis obliterans as a complication of allogeneic hematopoietic cell…
- Trial name
- NCT01327625
- Testing
- azithromycin + N-acetylcystein + inhaled corticosteroid
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Asan Medical Center
Chronic Myofascial Low Back Pain
Dry Dynamic Cupping vs Instrument-Assisted Soft Tissue Mobilization for Chronic Myofascial Low Back Pain
This study aims to compare the effects of Dry Dynamic Cupping and Instrument-Assisted Soft Tissue Mobilization (IASTM) in patients with chronic myofascial low back pain.
- Trial name
- NCT07685340
- Testing
- Instrument Assisted Soft Tissue Mobilization (IASTM), dry cupping
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Ibadat International University, Islamabad
oGHVD
Study of d-MAPPS™ Ophthalmic Solution, Safety, Tolerability, and Efficacy in the Treatment of Chronic Ocular Graft-Versus-Host Disease (oGVHD)
A Double-Masked, Randomized, Placebo-Controlled Study of the Safety, Tolerability, and Efficacy of d-MAPPS™ Ophthalmic Solution in the Treatment of Chronic Ocular Graft-Versus-Host Disease (oGHVD)
- Trial name
- oGVHD (NCT06852768)
- Testing
- d-MAPPS, PI and Patient Masked
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Regenerative Ocular Immunobiologics LLC
Mucositis, Graft-versus-host Disease
Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX
A comparative trial where all patients will receive daily doses of tacrolimus (TAC) until day +60 when tapering will begin, in the absence of graft-versus-host disease (GVHD), and discontinued by day +180.
- Trial name
- NCT00360685
- Testing
- Tac+MTX, TAC + MMF
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Graft Versus Host Disease, Leukemia
Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD
RATIONALE: Allogeneic hematopoietic stem cell transplant (HSCT) is a treatment that can cure acute leukemia and myelodysplasia. After giving the patient chemotherapy and total body irradiation to stop the growth of cancer and…
- Conditions
- Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT00914940
- Testing
- Fludarabine Phosphate, Tacrolimus, Thiotepa
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Fred Hutchinson Cancer Center
Graft Vs Host Disease, Extracorporeal Photopheresis
Photopheresis in GvHD After Hematopoietic Transplantation: Characteristics of the Procedure and of the Cell Product
This is an observational study on extracorporeal photopheresis,an established therapy for the treatment of Graft versus Host Disease (GvHD) post allogeneic haemopoietic stem cell transplantation.
- Trial name
- 3594 (NCT05718674)
- Testing
- Extracorporeal Photopheresis
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Graft vs Host Disease, Hematopoietic Stem Cell Transplantation
Mycophenolate Mofetil for the Prophylaxis of Graft-versus-host Disease in High Risk Allogeneic Stem Cell Transplantation
There is a significant (50-80%) risk of acute graft-versus-host disease(GVHD) and early mortality (30%) associated with high risk stem cell transplantation (SCT) such as that from a matched unrelated donor or HLA-mismatch…
- Trial name
- NCT00563589
- Testing
- mycophenolate mofetil, methotrexate, cyclosporin, Methotrexate and cyclosporin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hospital Authority, Hong Kong
Acute-graft-versus-host Disease, Steroid Refractory Acute Graft Versus Host Disease
Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT)
An Early Access Program for patients with steroid refractory acute GvHD after hematopoietic stem cell transplantation. This Program is available for female and male who are recipients of allogenic HSCT and who have been newly…
- Conditions
- Acute-graft-versus-host Disease, Steroid Refractory Acute Graft Versus Host Disease, Graft-versus-host-disease, Graft Vs Host Disease
- Trial name
- NCT03172455
- Testing
- Glassia
- Sponsor
- Impatients N.V. trading as myTomorrows
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Pain, Healthy
Predicting Central Pain Among People With a Spinal Cord Injury by Evaluating Mechanisms Regulating Pain and Efficacy Testing of the TENS Apparatus
People with a Spinal Cord Injury can develop chronic pain within months of the injury. Up to 80% of the patients will develop chronic pain called "central pain" and describe the pain as: burning, stabbing, or "like electricity."…
- Trial name
- NCT01726881
- Testing
- Thermal stimulation, Mechanical stimulation, Transcutaneous Electrical Nerve Stimulator (TENS)
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Constrictive Bronchiolitis, Bronchiolitis Obliterans
Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome
Background: Bronchiolitis obliterans or bronchiolitis obliterans syndrome is a lung disorder that occurs as a complication of either lung transplantation or bone marrow/blood stem cell transplantation.
- Conditions
- Constrictive Bronchiolitis, Bronchiolitis Obliterans, Graft vs Host Disease, Bronchiolitis, Exudative
- Trial name
- NCT01287078
- Testing
- Cyclosporine Inhalation Solution
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic GVHD
Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801)
This study is designed as a combined Phase II/III, randomized, open label, multicenter, prospective comparative study of sirolimus plus prednisone versus sirolimus/calcineurin-inhibitor plus prednisone for the treatment of…
- Trial name
- NCT01106833
- Testing
- Sirolimus + calcineurin inhibitor + prednisone, Sirolimus + prednisone
- Where
- 31 sites in United States
- Volunteers
- 151 people
- Sponsor
- Medical College of Wisconsin
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