Clinical trials: Graft Complication
Diabetic Foot Ulcers, Venous Ulcers
Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds
This study will examine differences in the process of wound-healing in patients treated with platelet rich plasma (a concentration of proteins derived from a patients own blood) applied to the wound as a gel; injected into the…
- Conditions
- Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- CMS (NCT02071979)
- Testing
- Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Arteriocyte, Inc.
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Pain, Postoperative
Platelet Rich Fibrin VS Hyaloronic Acid in Management of Pain After Harvesting a Free Gingival Graft
Comparative study to assess the efficacy of topical application of 0.2% hyaluronic acid vs platelet rich fibrin in decreasing a postoperative pain following free gingival graft procedure . .
- Trial name
- NCT03814707
- Testing
- Topical application of 0.2% hyaluronic acid gel, Platelet rich fibrin
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- mostafa soliman
End Stage Kidney Disease
The Vascutek Rapidax™ II Post Market Surveillance Registry
Multicentre, prospective, observational post-market registry. To monitor and collect data on the post-market clinical safety and performance of the Vascutek Rapidax II Vascular Access Graft.
- Trial name
- NCT01977508
- Testing
- ePTFE vascular access grafts
- Where
- 3 sites in Germany
- Volunteers
- 24 people
- Sponsor
- Vascutek Ltd.
Interstitial Fibrosis, Kidney Transplant; Complications
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard…
- Conditions
- Interstitial Fibrosis, Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure and Rejection
- Trial name
- NCT05285878
- Testing
- Fingolimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Bone Marrow Transplant Complications
Vaginal Microbiome and the Development of Vulvovaginal Graft Versus Host Disease
Allogeneic stem cell transplantation (also termed "bone marrow transplantation") involves transferring stem cells from a healthy person (the donor) to the patient, after high-intensity chemotherapy or radiation, given to destroy…
- Trial name
- NCT05316740
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs on Early Graft Function Recovery After DCD Kidney Transplant.
This study is designed to investigate whether allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) can promote function recovery in patients with poor early graft function after kidney transplantation from Chinese…
- Trial name
- NCT02563366
- Testing
- BM-MSCs, Saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Anterior Cruciate Ligament Reconstruction
Study of Pain Management Techniques Following Anterior Cruciate Ligament Repair Surgery
Patients scheduled to undergo knee arthroscopy with anterior cruciate ligament repair with graft from the ipsilateral hamstrings and gracilis will be randomized to one of three groups.
- Trial name
- NCT01868282
- Testing
- Hamstrings block, Obturator block, Control group
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Renal Failure , Chronic, Graft Failure
Study to Compare the Outcome of Receiving Continued Immunosuppression Versus Stopping Immunosuppression at 6 Months to Safely Prevent Human Leukocyte Antigen (HLA) Sensitization in Patients With Late Renal Graft Failure
The goal of this clinical trial is to compare the degree of HLA sensitization at 2 years in patients with late renal graft failure (> 3 months) when receiving reduced immunosuppressant treatment versus stopping immunosuppression…
- Conditions
- Renal Failure , Chronic, Graft Failure, Graft Rejection, Allograft
- Trial name
- NCT06676696
- Testing
- Continue low dose calcineurin inhibitor (CNI), Calcineurin inhibitor withdrawal at 6 months
- Where
- Spain
- Volunteers
- 202 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
End Stage Kidney Disease, Delayed Graft Function
Better Evidence for Selecting Transplant Fluids
End-stage kidney disease (ESKD) is a significant, expensive health problem. Kidney transplantation improves survival, quality of life, and is much cheaper than dialysis treatment for ESKD.
- Conditions
- End Stage Kidney Disease, Delayed Graft Function, Kidney Transplant; Complications
- Trial name
- BEST-Fluids (NCT03829488)
- Testing
- Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP
- Where
- 18 sites in Australia, New Zealand
- Volunteers
- 808 people
- Sponsor
- The University of Queensland
Coronary Artery Bypass Grafting, Postoperative Pain
Preoperative Pain Neuroscience Education in Patients Undergoing CABG
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting…
- Trial name
- PNE-CABG (NCT07783750)
- Testing
- Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- İsmail Palalı
Coronary Artery Bypass Grafting, Postoperative Acute Kidney Injury
Trajectory-Based Phenotyping After Coronary Artery Bypass Surgery
Coronary artery bypass grafting is a commonly performed heart surgery, but patients may have different risks for postoperative complications even when their preoperative risk scores are similar.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Acute Kidney Injury, Postoperative Complications, Risk Stratification
- Trial name
- NCT07598682
- Testing
- Early Postoperative Phenotype Classification
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Cancer
Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant
RATIONALE: Donor mesenchymal stem cell infusion may be an effective treatment for acute or chronic graft-versus-host disease caused by a donor stem cell transplant.
- Trial name
- NCT00361049
- Testing
- graft versus host disease prophylaxis/therapy, fluorescence in situ hybridization, immunoenzyme technique
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- Case Comprehensive Cancer Center
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Surgical Site Infections
Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.
- Trial name
- MIR-CABG (NCT01949935)
- Testing
- Mupirocin
- Where
- Canada
- Volunteers
- 974 people
- Sponsor
- Horizon Health Network
aGVHD, Stem Cell Transplant Complications
First Line Therapy for High Risk Acute GVHD
The purpose of this study is to determine the efficacy and safety of combined Ruxolitinib With Corticosteroids as First Line Therapy for the Treatment of High risk aGVHD(acute graft-versus-host disease )
- Trial name
- NCT04061876
- Testing
- Ruxolitinib, Corticosteroid
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Chinese PLA General Hospital
Arteriovenous Graft, Arteriovenous Fistula
Validation of Arterio Venous Access Stage (AVAS) Classification
VAVASC trial is an observational multicentre study. The aim of this trial is to validate AVAS (arteriovenous vascular access stage) classification.
- Conditions
- Arteriovenous Graft, Arteriovenous Fistula, Dialysis Access Malfunction, Kidney Failure
- Trial name
- VAVASC (NCT04796558)
- Testing
- AVAS Classification
- Where
- Czechia
- Volunteers
- 800 people
- Sponsor
- Vascular surgery, University hospital Královské Vinohrady, Prague
Hemodynamic Instability, Postoperative Complications
Fluid Responsiveness: SVV vs esSVV in Mechanically Ventilated and Spontaneously Breathing Patients
Postoperative period after off-pump coronary artery bypass grafting (OPCAB) can be a challenging area for emerging methods for less-invasive continuous hemodynamic monitoring.
- Trial name
- NCT04786652
- Testing
- estimated stroke volume variation (esSVV, Nihon Kohden, Japan), Assessment of fluid responsiveness in mechanically ventilated patients after OPCAB, Assessment of fluid responsiveness in spontaneously breathing patients at 18 hrs of the postoperative period
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Kidney Failure, Kidney Diseases
Study Evaluating Sirolimus in the Treatment of Kidney Transplant
The aim of this study is to test whether withdrawal of calcineurin inhibitors, followed by treatment with sirolimus, may improve renal function in renal transplant recipients with chronic allograft nephropathy.
- Trial name
- NCT00282217
- Testing
- Sirolimus
- Where
- 13 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer