Clinical trials: Graft-versus-Host Disease
Uremia; Chronic, Cardiovascular Diseases (CVD)
Prevention and Management of Cardiovascular and Cerebrovascular Complications in Maintenance Hemodialysis (MHD) Patients
Background and Purpose: This clinical study aims to explore and validate two innovative treatment strategies to address two major challenges faced by patients on maintenance hemodialysis (uremia): the high incidence of…
- Conditions
- Uremia; Chronic, Cardiovascular Diseases (CVD), Cerebrovascular Disorders, Intradialytic Hypotension
- Trial name
- NCT07335471
- Testing
- Continuous High-Glucose Infusion and Regular Hemoperfusion in Maintenance Hemodialysis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Graft Versus Host Disease, Acute
A Study of CYP-001 in Combination With Corticosteroids in Adults With High-risk aGvHD
This study is a prospective randomized placebo-controlled phase 2 study to compare CYP-001 plus corticosteroids (CS) to placebo plus CS in allogeneic hematologic stem cell transplant recipients with HR-aGvHD.
- Trial name
- NCT05643638
- Testing
- CYP-001: Cymerus induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs), Corticosteroids
- Where
- 39 sites in United States, Australia and 5 more
- Volunteers
- 65 people
- Sponsor
- Cynata Therapeutics Limited
Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
The purpose of the study is to evaluate whether treatment with ibrutinib as a monotherapy results in a clinically significant improvement in progression free survival (PFS) as compared to treatment with ofatumumab in patients…
- Trial name
- RESONATE™ (NCT01578707)
- Testing
- ofatumumab, ibrutinib
- Where
- 76 sites in United States, Australia and 8 more
- Volunteers
- 391 people
- Sponsor
- Pharmacyclics LLC.
Preventive Care
Impact of a Health Intervention on Some Indicators in the Care of Chronic Complex Patient (CCP).
The aim of this study is to assess the effectiveness of proactive and integrated healthcare program for chronic complex patients (CCP).
- Trial name
- CCP (NCT03091036)
- Testing
- Proactive healthcare intervention
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- María José del Olmo Rubio
Acute Graft Versus Host Disease
Clinical Trial With MSC for Graft Versus Host Disease Treatment
Sequential administration of MSCs obtained from adipose tissue is an effective and safe treatment for acute graft versus host disease refractory to first-line treatment.
- Trial name
- NCT02687646
- Testing
- Adult Allogeneic Mesenchymal cells from adipose tissue.
- Where
- 6 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Stem Cell Transplantation, Graft Vs Host Disease
Thymoglobuline in Non-myeloablative Allogeneic Stem-cell Transplantation
Allogeneic stem cell transplantation is the treatment of choice for a growing number of malignant and non-malignant indications.
- Trial name
- NCT00130754
- Testing
- Thymoglobuline
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Graft-versus-host Disease
Clinical and Biomarker Study of the Efficacy of Extracorporeal Photopheresis in Graft-versus-host Disease
The aims of the study: 1. To evaluate the clinical efficacy of the use of extracorporeal photopheresis in the treatment of Graft-versus-host disease under standard clinical indications as pre-defined by the participants Centers…
- Trial name
- BIOECP_GVHD (NCT03124056)
- Testing
- Extracorporeal photopheresis
- Volunteers
- 62 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Hematologic Malignancy, Bone Marrow Transplant
Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation
The purpose of this study is to evaluate the safety of reducing and ultimately eliminating anti-thymocyte globulin (ATG) from the haplo-cord transplant conditioning regimen and replacing it with tocilizumab, an IL-6 receptor…
- Trial name
- NCT04395222
- Testing
- Tocilizumab, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Weill Medical College of Cornell University
Gastritis
Efficacy and Safety of FEXUCLUE Tab. In Patients With Acute or Chronic Gastritis
This study aims to evaluate the efficacy of Fexuclue tablets in improving gastrointestinal symptoms based on patient-reported outcomes (PROs), by comparing assessments before and after treatment.
- Trial name
- NCT06948487
- Where
- South Korea
- Volunteers
- 12,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Graft Versus Host Disease
Relationship Between "FODMAPs" and "GVHD"
With the stem cell transplanting increasing, patients which effected with "GVHD" were also increased. To evaluation the relationship between "FODMAPs" and "GVHD", Bone marrow transplant patients were recruited.
- Trial name
- NCT04660487
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Acute Graft vs Host Disease, Allogeneic Bone Marrow Transplantation
Pediatric GVHD Low Risk Steroid Taper Trial
The standard treatment for acute graft-vs-host disease (GVHD) is to suppress the activity of the donor immune cells using steroid medications such as prednisone.
- Conditions
- Acute Graft vs Host Disease, Allogeneic Bone Marrow Transplantation, Adverse Effects
- Trial name
- NCT05090384
- Testing
- Prednisone
- Where
- 11 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- John Levine
Stroke, Upper Extremity Paresis
Functional Recovery in Stroke Patients With Task-Specific Robot-Aided Arm Therapy
The goal of this study is to determine whether task-oriented, robot-aided therapy is more effective than conventional physical and occupational therapy at promoting functional recovery of the affected arm in chronic hemiparetic…
- Trial name
- NCT00719433
- Testing
- robot therapy (ARMin), conventional therapy
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- University of Zurich
Lung Transplantation Rejection
Prospective Lung Transplant Database for Genetic Research
This study will create a database of clinical and biological research for use in future studies, with information obtained from lung transplant recipients.
- Trial name
- NCT00339209
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Graft Versus Host Disease
Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD
This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug Natalizumab in treating Acute Graft-Versus-Host Disease (GVHD) in the Gastrointestinal (GI) Tract.
- Trial name
- NCT02176031
- Testing
- Natalizumab, Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Dana-Farber Cancer Institute
Graft Versus Host Disease in Eye, Ocular Complications
Ocular Complications From Cancer Therapy - Patient Registry and Biobank
The purpose of this study is to collect data on patients seen at University of Maryland after undergoing cancer therapy. Previous medications, ocular history, medical history, clinical evaluations, surgical procedures and…
- Conditions
- Graft Versus Host Disease in Eye, Ocular Complications, Inflammatory Dry Eye Disease
- Trial name
- NCT06874283
- Testing
- Eye exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Graft Vs Host Disease, Inflammatory Bowel Diseases
Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation (The PREDICT Trial)
The goal of the Precision Diagnosis in Inflammatory Bowel Disease, Cellular Therapies, and Transplantation (PREDICT) trial is to apply a systems-biology approach to enable precision diagnostics for the key immunologic outcomes…
- Conditions
- Graft Vs Host Disease, Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
- Trial name
- PREDICT (NCT03369353)
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Stem Cell Transplant Complications, Acute Graft Versus Host Disease
Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region.
- Conditions
- Stem Cell Transplant Complications, Acute Graft Versus Host Disease, Acute Kidney Injury, Major Adverse Cardiac Events
- Trial name
- NCT06386445
- Testing
- Serum metabolomics sequencing
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hemopathy
Evaluation of a Kit for the Prediction of the Risk of Graft Versus Host Disease
This study is a proof of concept that will assess the Predictor's kit performances. The test will be performed by several technicians, in immunological laboratories of several sites in France.
- Trial name
- Predictor007 (NCT02751112)
- Testing
- Predictor' kit
- Where
- 4 sites in France
- Volunteers
- 34 people
- Sponsor
- Imagine Institute
Graft Versus Host Disease, Recurrent Adult Acute Lymphoblastic Leukemia
Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease
This randomized phase III trial is studying low-dose prednisone or methylprednisolone to see how well they work compared with standard-dose prednisone or methylprednisolone in treating patients with newly diagnosed acute…
- Trial name
- NCT00929695
- Testing
- prednisone, methylprednisolone, questionnaire administration
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Fred Hutchinson Cancer Center
Migraine
Study of Efficacy and Safety of Erenumab in Adult Chronic Migraine Patients
The purpose of this study was to evaluate the efficacy and safety of erenumab in patients with chronic migraine in Asian population.
- Trial name
- DRAGON (NCT03867201)
- Testing
- Erenumab
- Where
- 63 sites in China, India and 7 more
- Volunteers
- 557 people
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.