Clinical trials: Graft-vs-host Disease
Graft-vs-Host Disease
Vulvovaginal Graft Versus Host Disease (VV-GVHD) in Women Who Underwent Transplantation Before and After Menarche
The study will evaluate the prevalence and characteristics of vulvovaginal graft versus host disease (VV- GVHD) in patients who underwent hematopoietic stem cell transplantation (HSCT) as girls or adolescents and will compare the…
- Trial name
- NCT01512498
- Where
- 2 sites in Israel
- Volunteers
- 70 people
- Sponsor
- Hadassah Medical Organization
Bronchiolitis Obliterans Syndrome
Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children
In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study.
- Trial name
- NCT04391335
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- The Hospital for Sick Children
Breast Neoplasms
Stem Cell Transplant With Th2/Tc2 Cells to Treat Advanced Breast Cancer
This Phase 1 trial will investigate the safety of a modified stem cell transplant procedure for treating advanced breast cancer.
- Trial name
- NCT00079625
- Testing
- Th2/Tc2 Cells
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
Electrical impedance tomography (EIT) is non-invasive and provides functional imaging of the lung and it could be a useful tool to diagnose chronic lung allograft dysfunction (CLAD) and specially Bronchiolitis Obliterans Syndrome…
- Conditions
- Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction, Bronchiolitis Obliterans Syndrome
- Trial name
- CLAD (NCT02863835)
- Testing
- EIT, Salbutamol nebulisation and with CPAP
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Graft Vs Host Disease, Graft-versus-host-disease
A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant
Patients in need of an allogeneic hematopoietic cell transplant (HCT) are at risk of developing graft-versus-host-disease (GVHD).
- Trial name
- NCT04337515
- Testing
- CliniMacs®
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Christopher Dvorak
Chronic Wounds
P.E.M.F. Therapy of Chronic Wounds
To measure the effectiveness of pulsed electromagnetic fields (PEMF) as an adjunct wound care therapy.
- Trial name
- NCT05493943
- Testing
- Pulsed ElectroMagnetic Field (PEMF) therapy, Pulsed ElectroMagnetic (PEMF) therapy
- Volunteers
- 120 people
- Sponsor
- PEMF Systems, Inc.
Graft Versus Host Disease
Everolimus in Combination With Cyclosporine A and Prednisolone for the Treatment of Graft Versus Host Disease
The present protocol is a dose-finding and toxicity study in preparation of a randomised study comparing current standard treatment CSA/prednisolone with the new combination CSA/prednisolone/everolimus.
- Trial name
- NCT00373815
- Testing
- Everolimus
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
GVHD in the Setting of Haplo-HSCT
ATG-F VS ATG for the Prevention of GVHD
Anti-thymocyte globulin (ATG) preparative regimen in the setting of haploidentical stem cell transplantation (haplo-HSCT) is vital for inducing immune tolerance.The study aims to compare the efficacy and safety of ATG-F vs ATG…
- Trial name
- NCT03631563
- Testing
- Immunosuppressive Agent
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation
The stud will evaluate whether infusions of CD45RA-depleted lymphocytes from the donor early post-transplant is a safe way to improve immunity to common infections in recipients of TCR-alpha/beta depleted hematopoietic stem cell…
- Conditions
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Immune Deficiency Disease, Bone Marrow Failure Syndromes
- Trial name
- 45RA_NEG_DLI (NCT02337595)
- Testing
- CD45RA-depleted peripheral blood mononuclear cells
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Interstitial Cystitis, Chronic Prostatitis
Microbiomes of Pelvic Pain
This research study seeks to provide more insight as to how the microbiome affects or is affected by conditions causing chronic pelvic pain such as Interstitial Cystitis (IC), Chronic Prostatitis/Chronic Pelvic Pain Syndrome…
- Conditions
- Interstitial Cystitis, Chronic Prostatitis, Chronic Pelvic Pain Syndrome, Lower Urinary Tract Symptoms
- Trial name
- NCT01738464
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Graft Versus Host Disease
Prospective Outcomes of Second-Line Therapy in Acute Graft-Versus-Host Study Including ECP (POSTAGE)
This research trial studies medical chart review in determining outcomes of second-line therapy in patients with acute graft-versus-host disease previously treated with extracorporeal photopheresis or other systemic therapies.
- Trial name
- POSTAGE (NCT02151539)
- Testing
- medical chart review, quality-of-life assessment
- Where
- 7 sites in United States, Austria and 2 more
- Volunteers
- 19 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Graft-versus-host Disease (GVHD)
Study of Itacitinib in Combination With Corticosteroids for the Treatment of Acute GVHD
To determine if Itacitinib in combination with corticosteroids is safe and tolerable in patients with Grade IIB-IVD acute graft-versus-host disease (GVHD).
- Trial name
- NCT02614612
- Testing
- Itacitinib (200 mg), Itacitinib (300 mg), prednisone or methylprednisolone (corticosteroids)
- Where
- 23 sites in United States
- Volunteers
- 31 people
- Sponsor
- Incyte Corporation
Urinary Retention, Chronic
Evaluation of the Safety and Clinical Performance of the Connected Catheter Study
The objective of this study is to evaluate the safety and effectiveness of the Connected Catheter in males with chronic Urinary Retention, both in a clinical setting and an extended period of home use.
- Trial name
- NCT05330598
- Testing
- Connected Catheter
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Spinal Singularity
Acute Graft-versus-host Disease
Mesenchymal Stem Cells for Treatment of Refractory Acute Graft-versus-host Disease
The purpose of this study is to evaluate the utility of treating patients experiencing refractory acute graft-versus-host disease with ex-vivo-expanded BM-drived mesenchymal stem cells from third-party donors.
- Trial name
- NCT01765634
- Testing
- Mesenchymal stem cells, Non-mesenchymal stem cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Graft Versus Host Disease
Combination of Steroid and Humanized CD25 Monoclonal Antibody as First-line Therapy for aGVHD
The first-line treatment of acute graft-versus-host disease with humanized CD25 monoclonal antibody combined with glucocorticoid was used to study the remission rate of acute graft-versus-host disease, the cumulative incidence…
- Trial name
- NCT06473909
- Testing
- CD25 antibody combined glucocorticoid as first-line treatment
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Chronic Low Back Pain
Exposure Therapy and Safety-seeking Behavior in Chronic Low Back Pain
RATIONALE: Exposure in vivo therapy aims to reduce pain-related fear - a key maintaining factor of chronic low back pain- while increasing level of daily functioning, despite the pain.
- Trial name
- NCT01971151
- Testing
- Exposure therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Maastricht University Medical Center
Hematological Malignancies
A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors
It is hypothesized that engraftment when administering cyclophosphamide post the stem cell infusion will increase, the incidence of graft versus host disease (GVHD) and day 100 mortality will decrease, and the use of…
- Trial name
- NCT01349101
- Testing
- Total Body Irradiation, Cyclophosphamide, Tacrolimus
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Graft Versus Host Disease, Acute, Hematopoietic Stem Cell Transplantation
Infliximab Efficacy, TDM and Serum TNFα Levels in Pediatric HSCT Recipients With aGVHD: Prospective Observational Study
In children receiving a hematopoietic stem cell transplant (HSCT), blood levels of TNFalpha (an inflammatory cytokine) at the onset of the acute GVHD (graft-versus-host disease) could be correlated with the severity of the…
- Trial name
- NCT05362630
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- University of Pisa
Acute Graft Versus Host Disease, Steroid Refractory Graft Versus Host Disease
Novel BET Inhibitor PLX51107 for Steroid-Refractory Acute GVHD
This phase Ib/II trial studies the side effects of PLX51107 in treating steroid-refractory acute graft versus host disease (GVHD).
- Trial name
- NCT04910152
- Testing
- BRD4 Inhibitor PLX51107
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Hannah Choe, MD
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant
This phase I/II trial studies whether stopping cyclosporine before mycophenolate mofetil is better at reducing the risk of life-threatening graft-versus-host disease (GVHD) than the previous approach where mycophenolate mofetil…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00078858
- Testing
- fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 37 people
- Sponsor
- Fred Hutchinson Cancer Center
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