Clinical trials: Graft-vs-host Disease
Graft-vs-host Disease
Preemptive Therapy of GVHD
Graft-vs-host disease (GVHD) causes substantial mortality, morbidity and poor quality of life after blood or marrow transplantation (BMT).
- Trial name
- NCT01994824
- Testing
- rabbit antithymocyte globulin
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Hepatitis B Virus Infection, Children
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Tolerant Chronic Hepatitis B
This study aims to evaluate the efficacy and safety of entecavir monotherapy versus sequential entecavir plus pegylated interferon α-2b in achieving functional cure in immune-tolerant, HBeAg-positive children aged 3-6 years with…
- Conditions
- Hepatitis B Virus Infection, Children, Chronic Hepatitis B
- Trial name
- NCT07345624
- Testing
- Entecavir, Entecavir + Pegylated interferon α-2b
- Volunteers
- 80 people
- Sponsor
- Qing-Lei Zeng
Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse
Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Duvortuxizumab (JNJ-64052781) Plus Ibrutinib in Lymphoma
The purpose of this study is to determine whether duvortuxizumab and ibrutinib can be combined safely and to establish the maximum tolerated dose (MTD) in Part 1 and the recommended Phase 2 dose (RP2D) and to further explore the…
- Conditions
- Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Follicular, Lymphoma, Mantle-Cell
- Trial name
- NCT02743546
- Testing
- Duvortuxizumab, Ibrutinib
- Sponsor
- Janssen Research & Development, LLC
Burns, Knee Injuries
Opioid Laws and Pediatric Use
The legitimate need for opioid medications for acute pain management in pediatric trauma patients is recognized, however, the high dose and duration of opioid drugs prescribed by medical providers has been associated with an…
- Conditions
- Burns, Knee Injuries, Opioid Use, Pain
- Trial name
- NCT04543227
- Testing
- Opioid Use 90-Days Post Treatment
- Where
- United States
- Volunteers
- 980 people
- Sponsor
- Nationwide Children's Hospital
Leukemia, Acute Myeloid, Leukemia, Lymphoblastic,Acute
Brentuximab Vedotin Prevention of (GVHD) After Unrelated Allogeneic Stem Cell Transplantation
This pilot clinical trial studies the safety and maximum tolerated dose of brentuximab vedotin when given with tacrolimus and methotrexate after unrelated allogeneic donor stem cell transplant in patients with acute myeloid…
- Conditions
- Leukemia, Acute Myeloid, Leukemia, Lymphoblastic,Acute, Myelodysplastic Syndromes
- Trial name
- NCT01700751
- Testing
- brentuximab vedotin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Stem Cell Transplant Complications, Acute Graft Versus Host Disease
Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region.
- Conditions
- Stem Cell Transplant Complications, Acute Graft Versus Host Disease, Acute Kidney Injury, Major Adverse Cardiac Events
- Trial name
- NCT06386445
- Testing
- Serum metabolomics sequencing
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm
Evaluating the Effects of Propionate and Butyrate Supplementation on the Intestinal Health of Healthy Volunteers
This clinical trial evaluates how propionate and butyrate supplementation alters intestinal health in healthy volunteers and whether it would be feasible to administer these supplements to patients undergoing allogeneic…
- Conditions
- Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07611370
- Testing
- Biospecimen Collection, Microencapsulated Sodium Butyrate, Microencapsulated Sodium Propionate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Graft-versus-host Disease, Hematopoietic Stem Cell Transplantation
Maraviroc in Patients Undergoing Non-Myeloablative Allogeneic Stem-Cell Transplantation
This study investigates the effectiveness and safety of Maraviroc (an oral medication given twice daily given in addition to the standard GVHD prophylaxis) in preventing Graft versus Host Disease (GVHD) in patients undergoing…
- Trial name
- NCT00948753
- Testing
- Maraviroc 150 MG, Maraviroc 300 mg, Maraviroc 300 mg Phase II
- Volunteers
- 38 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Hypertensive Intracerebral Hemorrhage
Robotic Assisted Evacuation of Subacute and Chronic Supratentorial Deep Hypertensive Intracerebral Hemorrhage
Robotic Assisted Evacuation of Subacute and Chronic Supratentorial Deep Hypertensive Intracerebral Hemorrhage for Accelerating Functional Rehabilitation (RESCUE-CHAIN): a Multi-center Randomized Controlled Trial
- Trial name
- NCT04957862
- Testing
- Robotic Assisted Evacuation
- Volunteers
- 428 people
- Sponsor
- Shanghai Changzheng Hospital
Hepatitis B, Chronic Hepatitis B Atypical
Safety, Tolerability, Pharmacokinetics and Antiviral Activity of IONIS-HBVRx in Treatment-Naïve Patients With Chronic HBV Infection
To examine the safety and tolerability of IONIS-HBVRx administration to treatment-naive patients with chronic hepatitis B virus infection
- Trial name
- NCT02981602
- Testing
- IONIS-HBVRx
- Where
- 7 sites in Hong Kong, South Korea
- Volunteers
- 31 people
- Sponsor
- GlaxoSmithKline
Graft Versus Host Disease, Hyperkalemia
Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Blood transfusions are required for patients undergoing a craniosynostosis repair due to the significant amount of blood loss. Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels…
- Conditions
- Graft Versus Host Disease, Hyperkalemia, Craniectomy, Synostectomy
- Trial name
- NCT02483702
- Testing
- Irradiated Blood Transfusions, Non-Irradiated Blood Transfusions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Acute Graft Versus Host Disease
Multicenter Study Of Natalizumab Plus Standard Steroid Treatment For High Risk Acute Graft-Versus-Host Disease
This research trial is designed to study the safety and effectiveness of combining the study drug, Natalizumab (Tysabri®) with the standard treatment, the use of steroids, as a new treatment for acute graft versus host disease…
- Trial name
- NCT02133924
- Testing
- natalizumab, steroids
- Where
- 12 sites in United States
- Volunteers
- 76 people
- Sponsor
- John Levine
Hematopoietic Stem Cell Transplantation
Dose Study of Antithymocyteglobulin in Haploidentical Allogeneic Stem Cell Transplantation
The purpose of this study is to compare the incidences of GVHD in haploidentical hematopoietic stem cell transplant recipients receiving different dose of antithymocyte globulin (ATG) for acute graft-versus-host disease(aGVHD)…
- Trial name
- NCT02643589
- Testing
- ATG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Oral Chronic Graft vs Host Disease
Clobetasol for Oral Graft-Versus-Host Disease
Background: Oral graft-versus-host disease (GVHD) is a possible complication of bone marrow transplants. It is the result of the donor cells trying to attack the recipients body.
- Trial name
- NCT01557517
- Testing
- Clobetasol Oral Rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
GVHD - Graft-Versus-Host Disease
Phase I-II PTCy, Bortezomib and Sitagliptin for Prevention of GvHD Following Allogeneic HSCT
Phase I-II studying post transplant cyclophosphamide, bortezomib and sitagliptin for GvHD prevention in allogeneic HSCT. Adults with hematologic malignancies undergoing an RIC allogeneic PBSC transplant from a 5/6 or 6/6 sibling…
- Trial name
- NCT07675174
- Testing
- Post transplant cyclophosphamide, bortezomib and sitagliptin in 3+3 design to MTD
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwell Health
Migraine Disorders
Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE
The primary objective of this study is to evaluate the safety and efficacy of occipital nerve stimulation (ONS) using the Boston Scientific Corporation (BSC) Precision™ System in the management of intractable chronic migraine…
- Trial name
- OPTIMISE (NCT01775735)
- Testing
- Occipital nerve stimulator
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- Boston Scientific Corporation
Chronic Granulomatous Disease
Modified Stem Cell Transplantation Procedure for Treating Chronic Granulomatous Disease
This study will investigate the safety and effectiveness of a new stem cell transplant procedure for treating chronic granulomatous disease (CGD) in patients with active infection.
- Trial name
- NCT00006417
- Testing
- Stem cell transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Shoulder; Dislocation, Chronic
Clinical and Radiographic Outcomes in Arthroscopic "Inlay"Bristow Surgery With Screw Fixation vs Suture-button Fixation
Retrospective comparative case-cohort study to investigate the efficacy of the modified arthroscopic Bristow-Latarjet surgery and to compare the clinical and radiographic outcomes using screw fixation vs suture-button fixation.
- Trial name
- NCT04460118
- Testing
- Bristow surgery fixed by the screw, Bristow surgery fixed by the suture button
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Peking University Third Hospital
Acute Myeloid Leukemia (AML)
Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60…
- Trial name
- BIG-1 (NCT02416388)
- Testing
- Idarubicin, Daunorubicin, HD Cytarabine
- Where
- 56 sites in France
- Volunteers
- 3,100 people
- Sponsor
- University Hospital, Angers
Pediatric Feeding Disorder, Chronic, Pediatric Feeding Dysfunction, Acute
Parent Acceptance and Commitment Therapy (PACT) for Parents of Children With Pediatric Feeding Disorder
This is a pilot study of randomized clinical trial of Parent Acceptance and Commitment Therapy (PACT) vs. an attention-control condition (placebo) for improving the mental health of parents of children with pediatric feeding…
- Trial name
- PACT (NCT06001398)
- Testing
- Parent Acceptance and Commitment Therapy (PACT), Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Mercy Hospital Kansas City
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