Clinical trials: Grafting, Corneal
Hyperopia
Hyperopia Correction Using the NTK Optimal Keratoplasty (Opti-K) System
The purpose of this U.S. Clinical Trial on treatment of sighted eyes is to investigate the safety and effectiveness of optimal keratoplasty (Opti-K™) treatments for hyperopia correction using the NTK Enterprises (NTK) Opti-K…
- Trial name
- NCT01028937
- Testing
- Optimal Keratoplasty
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NTK Enterprises, Inc.
Corneal Endothelial Cell Dysfunction, Corneal Endothelial Cell
Safety and Efficacy of Cultivated Allogeneic Corneal Endothelial Cells Attached to a Hydrogel Substrate (Endo-Tek™) as a Treatment for Corneal Endothelial Cell Dysfunction
Primary Objective: To determine the safety and feasibility of using Endo Tek™ for the treatment of corneal endothelial disease/dysfunction.
- Trial name
- NCT07874503
- Testing
- HCEC graft
- Where
- El Salvador
- Volunteers
- 30 people
- Sponsor
- OcuCell
Cataract, Corneal Disease
New Disposable Contact Lens Patient Interface For The Lensx Laser
The objective of this study is to evaluate the ease of use of a modified, disposable contact lens and suction ring assembly.
- Trial name
- NCT01141985
- Testing
- LenSx Laser modified disposable contact lens
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- LenSx Lasers Inc.
Corneal Transplantation
Corneal Endothelium Delivery Instrument
The purpose of this study is to determine whether the surgical outcomes in patients undergoing Descemet's Stripping Endothelial Keratoplasty (DSEK) are improved with the use of an insertion device over the traditional forceps…
- Trial name
- NCT00874835
- Testing
- EndoSaver™ Corneal Endothelium Delivery Instrument
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ocular Systems, Inc.
Corneal Opacity
Clinical Outcomes of the Gore Synthetic Cornea Device
Study objective is to evaluate the initial safety and effectiveness of the GORE Synthetic Cornea Device in the treatment of loss of corneal clarity in patients who are candidates for corneal transplantation
- Trial name
- NCT06174376
- Testing
- GORE Synthetic Cornea Device
- Where
- 2 sites in Mexico
- Volunteers
- 10 people
- Sponsor
- W.L.Gore & Associates
Corneal Transplantation
Safety and Efficacy of Corneal Preservation Solution for Corneal Transplantation
The goal of this clinical trial is to learn if a corneal preservation solution can safely and effectively preserve donor corneas for corneal transplantation in patients who need penetrating keratoplasty (PKP) or endothelial…
- Trial name
- NCT07874568
- Testing
- penetrating keratoplasty
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Persistent Corneal Epithelial Defect
An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED
This is a phase 3, randomized, multicenter, double-masked, parallel group, vehicle-controlled prospective clinical trial to evaluate the safety and efficacy of cenegermin in inducing complete epithelial healing in participants…
- Trial name
- NCT07519902
- Testing
- Cenegermin, Vehicle
- Where
- 77 sites in United States, Argentina and 12 more
- Volunteers
- 150 people
- Sponsor
- Dompé Farmaceutici S.p.A
Corneal Edema, Corneal Endothelial Dysfunction
AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction
The purpose of this study is to assess the efficacy and safety of single injection dose of AURN001 compared with placebo in adult participants with corneal edema secondary to corneal endothelial dysfunction.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Fuchs Endothelial Corneal Dysfunction, Pseudophakic Bullous Keratopathy (PBK)
- Trial name
- NCT07368959
- Testing
- Combination Product: AURN001 + Y-27632
- Where
- 12 sites in United States
- Volunteers
- 130 people
- Sponsor
- Aurion Biotech
Corneal Blindness
A Clinical Study to Evaluate the KeraKlear Keratoprosthesis in Patients With Corneal Opacity
To evaluate the safety and probable benefit of the KeraKlear Non-Penetrating Keratoprosthesis when implanted in an eye with corneal opacity that is at high risk of complications with PK.
- Trial name
- NCT03126903
- Testing
- KeraKlear Non-Penetrating Keratoprosthesis
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- KeraMed, Inc.
Atopic Keratoconjunctivitis
An Efficacy and Safety Study of DFL24498 in the Treatment of AKC
This is a phase 3, multicenter, randomized, double-masked, parallel-group, vehicle-controlled study to evaluate the safety and efficacy of DFL24498 compared with vehicle ophthalmic solution, in participants with AKC.
- Trial name
- NCT07395232
- Testing
- DFL24498, Vehicle, dexamethasone sodium phosphate (DSP) ophthalmic solution
- Where
- 19 sites in United States, Italy and 1 more
- Volunteers
- 153 people
- Sponsor
- Dompé Farmaceutici S.p.A
Cataract
A Clinical Investigation of MINIVISC® PLUS 14 mg/ml Fermented Ophthalmic Viscosurgical Device (OVD-F), Used for Cataract Surgery and Implantation of Intraocular Lenses, Glaucoma Surgery, Anterior Segment Surgery and Corneal Transplantation (CGAC)
A clinical investigation to confirm the clinical safety and performance of OVD-F device MINIVISC® PLUS 1.4 % for cataract surgery and implantation of intraocular lenses, glaucoma surgery, anterior segment surgery and corneal…
- Trial name
- Minivisc01 (NCT07184437)
- Testing
- OVD-F device Minivisc®PLUS 14 mg/ml
- Where
- 6 sites in Belgium, Sweden
- Volunteers
- 134 people
- Sponsor
- Bohus Biotech AB
Corneal Sensation Reduced, Corneal Dystrophy
Defining the Operating Parameters for a Rebound-esthesiometer
The purpose of this study is to define the operating parameters for a new method to measure corneal sensitivity.
- Conditions
- Corneal Sensation Reduced, Corneal Dystrophy, Corneal Degeneration, Corneal Transplant Failure
- Trial name
- NCT04384094
- Testing
- Esthesiometer measurement
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icare Finland Oy
Dry Eye Disease
Study of Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Who Are Scheduled for Laser Epithelial Keratomileusis (LASEK) Surgery
This study aims to evaluate the efficacy and safety of applying pulse Electrical Stimulation around eye after laser keratoplasty (LASEK) in patients with dry eye syndrome.
- Trial name
- NCT06120348
- Testing
- Charge-Balanced, Symmetric Nerve Stimulation
- Where
- 6 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- Nu Eyne Co., Ltd.
Corneal Transplantation
Ocular Penetration of 1.5% Levofloxacin and 0.5% Moxifloxacin During Corneal Transplant Surgery
Compare the corneal penetration of levofloxacin 1.5% and moxifloxacin 0.5% in patients undergoing penetrating keratoplasty (PK)
- Trial name
- NCT00764582
- Testing
- 1.5% levofloxacin ophthalmic solution, 0.5% moxifloxacin ophthalmic solution
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Santen Inc.
Corneal Transplant, Corneal Crosslinking
A Prospective Clinical Trial Designed to Evaluate the Repeatability and Reproducibility of the Intelon BOSS(tm) System
This is a prospective, open-label, single-site clinical trial designed to evaluate the repeatability and reproducibility of biomechanical imaging by the updated version of the BOSS device.
- Conditions
- Corneal Transplant, Corneal Crosslinking, Healthy Eyes
- Trial name
- NCT05423041
- Testing
- BOSS Imaging
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Intelon Optics, Inc
Corneal Ulcer
ACRO Biocornea Clinical Trial in Taiwan
The goal of this clinical trial is to investigate the safety and clinical performance of ABCcolla Collagen Ophthalmic Matrix used for anterior lamellar keratoplasty in patients suffering from corneal ulcer.
- Trial name
- NCT04054817
- Testing
- Lamellar keratoplasty-ABCcolla® Collagen Ophthalmic Matrix
- Where
- 3 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- ACRO Biomedical Co. Ltd
Corneal Transplantation, Corneal Graft Rejection
Study to Assess LX201 for Prevention of Corneal Allograft Rejection or Graft Failure in Subjects Who Have Experienced One or More Rejection Episodes Following Penetrating Keratoplasty
This study will evaluate the use of LX201 to prevent future graft rejection episodes and/or graft failure in patients who have undergone corneal transplantation and who have recently experienced a rejection episode due to an…
- Trial name
- NCT00447642
- Testing
- LX201
- Where
- 30 sites in United States, Germany
- Volunteers
- 122 people
- Sponsor
- Lux Biosciences, Inc.
Viral Keratitis, Blindness Eye
Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of BD111 CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy administered via corneal injection in participants with…
- Conditions
- Viral Keratitis, Blindness Eye, Herpes Simplex Virus Infection, Cornea
- Trial name
- NCT04560790
- Testing
- BD111 Adult single group Dose
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Corneal Edema
EndoArt® Implantation in Subjects With Chronic Corneal Edema - US Study
The EndoArt® device is intended to treat patients with chronic corneal edema due to endothelial dysfunction, in whom prior multiple keratoplasty (EK/PK) have failed, and who are not reasonable candidates for any form of corneal…
- Trial name
- NCT07344168
- Testing
- The EndoArt® (Corneal Artificial Endothelial layer)
- Volunteers
- 123 people
- Sponsor
- Eye-yon Medical