Clinical trials: Gram-positive Bacterial Infections
Surgery, Cardiac, Infection
Mediastinitis and Staphylococcus Aureus
Cardiac surgery with extracorporeal circulation (ECC) yields a deep immune system dysfunction that exposes patients to postoperative infectious complications.
- Trial name
- MEDIASTAPH (NCT03262558)
- Testing
- No intervention
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Rennes University Hospital
Latent Tuberculosis
Improving Rhode Island's Tuberculosis Preventive Services in Primary Care
This study explores primary care team members' knowledge, attitudinal, and skill gaps related to latent tuberculosis infection (LTBI) testing and treatment.
- Trial name
- NCT04188041
- Testing
- TB Infection ECHO
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Kent Hospital, Rhode Island
Pneumococcal Disease
Safety and Immunogenicity of 20vPnC in Toddlers With 2 Prior Doses of Prevenar 13
The purpose of this study is to understand the safety and effects of a study vaccine (20vPnC) in toddlers who had 2 prior doses of Prevnar 13.
- Trial name
- NCT05408429
- Testing
- 20-valent pneumococcal conjugate vaccine, 13-valent pneumococcal conjugate vaccine
- Where
- 43 sites in Hungary, Poland and 1 more
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tuberculosis, Healthy
Dose-Escalation Study to Evaluate the Safety and Immunogenicity of MTBVAC Vaccine in Comparison With BCG Vaccine.
The purpose of this study is to test the safety and immunogenicity of MTBVAC as a potential substitute for BCG vaccination. BCG vaccination has indeed demonstrated its major limitation in inducing protection against tuberculosis…
- Trial name
- MTBVAC (NCT02013245)
- Testing
- MTBVAC live vaccine, Commercially available BCG live vaccine
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biofabri, S.L
Pneumococcal Infectious Disease
A Clinical Trial to Observe the Safety of 23-Valent Pneumococcal Polysaccharide Vaccine in Target Population
An open clinical trial of a 23-valent pneumococcal polysaccharide vaccine (PPV23) developed by Sinovac Life Science Co., Ltd was conducted to evaluate the safety of Sinovac PPV23 in target population of individuals aged 2 years…
- Trial name
- NCT07071701
- Testing
- 23-valent pneumococcal polysaccharide vaccine, Influenza vaccine
- Where
- China
- Volunteers
- 19,267 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Tuberculosis
Using SMS Reminders, Phone Calls and Money Incentives to Enhance Linkage to Care of Presumptive TB Patients in Uganda
The major challenge in meeting the WHO's End TB Strategy- reducing tuberculosis (TB) deaths by 90% and incidence by 80% is the cascading patient loss-to-follow-up (LTFU) along the continuum of TB care.
- Trial name
- MILEAGE4TB (NCT05964842)
- Testing
- SMS, Phone call, Mobile money incentive
- Where
- 5 sites in Uganda
- Volunteers
- 2,355 people
- Sponsor
- Makerere University
Clostridium Difficile Infections
Treatment of CDI and Recurrence With Fecal Microbiota Transplant Using Promicrobioma
The increasing inappropriate use of antimicrobials, in addition to increasing selective pressure and inducing environmental resistance, is also a risk factor for the development of Clostridioides difficile infection (CDI).
- Trial name
- NCT06107569
- Testing
- Fecal microbiota transplant (Promicrobioma), Antibiotic
- Volunteers
- 24 people
- Sponsor
- Hospital Universitario Evangelico de Curitiba
Pulmonary Neoplasm, Pulmonary Tuberculosis
Could the Stroke Volume Variation Predict a Fluid Responsiveness in Thoracotomy?
There are some risks of pulmonary edema in patients undergoing pulmonary lobectomy with one lung ventilation. The overloading of fluid administration could be related to the development of pulmonary edema in patents after…
- Trial name
- NCT02331056
- Testing
- fluid loading, thoracoscopic pulmonary lobectomy, thoracotomy
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Samsung Medical Center
Impetigo
Safety and Efficacy of Mupirocin Gel in Children With Impetigo
The purpose of the study is to show non inferiority in terms of safety and efficacy of topical administration BID (Twice daily) of Mupirocin Gel 20 mg/g compared to topical administration of Mupirocin Ointment 20 mg/g TID (three…
- Trial name
- NCT04287777
- Testing
- Mupirocin gel, Mupirocin ointment
- Where
- 20 sites in Spain
- Volunteers
- 467 people
- Sponsor
- Reig Jofre Group
Tuberculosis
Pharmacokinetic Interaction Study in Indonesian Tuberculosis Patients Indonesia
Pharmacokinetic study in TB patients to determine the effect of rifampicin on the pharmacokinetic profile of moxifloxacin.
- Trial name
- NCT00306319
- Testing
- moxifloxacin
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Denture, Removable Partial Denture
Effectiveness of an Ultrasonic Denture Hygiene Intervention Program Among Community-dwelling Elders
Objectives: The objective of this study was to assess prospectively the effectiveness of ultrasonic denture hygiene interventions in improving denture cleanliness among community-dwelling elders.
- Conditions
- Denture, Removable Partial Denture, Denture Cleansers, Cetylpyridinium Chloride
- Trial name
- NCT03522272
- Testing
- Ultrasonic cleaning, Conventional denture hygiene
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tuberculosis
A Study to Evaluate Safety and Immunogenicity of AERAS-402
This Phase I study will be conducted as a randomized, double-blind, placebo-controlled study in healthy adult subjects who are HIV-negative, BCG-vaccinated, and have no evidence of tuberculosis infection.
- Trial name
- NCT01378312
- Testing
- AERAS 402
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aeras
Rifampin-Resistant Pulmonary Tuberculosis, Tuberculosis, Multidrug-Resistant (MDR-TB)
A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis Patients
This is a multicenter, randomized, double-blind, active-controlled Phase III study to evaluate the efficacy and safety of Sudapyridine (WX-081) combined with a background regimen (BR) in patients with rifampicin-resistant…
- Trial name
- WISH (NCT05824871)
- Testing
- Sudapyridine, Bedaquiline
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- Shanghai Jiatan Pharmatech Co., Ltd
Staphylococcal Infections
Study of Staphylococcus Aureus Colonization of the Posterior Nasal Cavity in Patients Undergoing Otorhinolaryngologic Surgery
Staphylococcus aureus nasal carriage is a major risk factor of infection with this bacterium. Staphylococcus aureus colonization of the posterior nasal cavity is still misunderstood.
- Trial name
- SREENSTAPH2 (NCT02595112)
- Testing
- Staphylococcus aureus carriage
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pulmonary Tuberculosis (TB)
ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD)
The purpose of this study is to assess pharmacokinetic parameters of atorvastatin at different doses when combined with the standard first line tuberculosis (TB) treatment regimen in adults with drug sensitive pulmonary TB.
- Trial name
- NCT07303699
- Testing
- Atorvastatin 20 mg, Atorvastatin 40 mg, Atorvastatin 60 mg
- Where
- 3 sites in Nigeria
- Volunteers
- 80 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Tetanus, Diphtheria
Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine
When two or more vaccines are administered concurrently, there is a concern on vaccine interaction, which can either enhance or suppress immune response to vaccine antigens.
- Conditions
- Tetanus, Diphtheria, Pneumococcal Infections
- Trial name
- NCT03552445
- Testing
- Tetanus-diphtheria (Td) and PCV13, PCV13 alone, Td alone
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Anthrax
Safety and Pharmacokinetics Study of Human Monoclonal Antibody (AVP-21D9)
Primary: To compare the safety profile of a single intravenous administration of AVP-21D9 as compared with Placebo Secondary: To evaluate the pharmacokinetics (PK) of a single intravenous administration of AVP-21D9 To evaluate…
- Trial name
- NCT01202695
- Testing
- AVP-21D9
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Pneumococcal Infections
Pneumococcal Vaccination of Fiji Infants
Pneumonia is the most common reason for admission of Fijian children to hospitals. The most common germ causing pneumonia is "streptococcus pneumoniae." It is a common cause of meningitis (infection around the brain and spinal…
- Trial name
- NCT00170612
- Testing
- Pneumovax 23, Prevnar
- Where
- Fiji
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Tuberculosis, Pulmonary
Safety and Efficacy of RUTI® With the Standard of Treatment for Tuberculosis
This study is proposed to evaluate the safety and efficacy of the RUTI vaccine in patients with pulmonary tuberculosis. Therapeutic vaccination of RUTI would stimulate the immune response not only against growing bacteria, but…
- Trial name
- CONSTAN-ARG (NCT05455112)
- Testing
- RUTI® Vaccine
- Where
- 2 sites in Argentina
- Volunteers
- 41 people
- Sponsor
- Archivel Farma S.L.
Hemoptysis, Haemoptysis
Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis
The study consist of a retrospective analysis of the etiologies, investigations and outcomes of patients presenting between 2005 to 2010 with hemoptysis in a North-American Tertiary center.
- Conditions
- Hemoptysis, Haemoptysis, Lung Disease, Pneumonia
- Trial name
- NCT02913365
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Université de Sherbrooke
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.