Clinical trials: Gram-positive Bacterial Infections
Malignant Neoplasms, Tuberculosis (TB)
Prophylaxis of Complications of Basic Therapy Using Naderin in Socially Significant Diseases
This interventional study evaluated the efficacy of Naderin (sodium nucleinate) for the prophylaxis of complications during basic therapy and medical rehabilitation in patients with socially significant diseases, including…
- Conditions
- Malignant Neoplasms, Tuberculosis (TB), HEPATITIS C (HCV)
- Trial name
- NADERIN-SSD (NCT07671508)
- Testing
- Naderin, Standard Therapy
- Volunteers
- 75 people
- Sponsor
- MIPO Clinic
Clostridium Difficile Infection
Oral Vaccination Against Clostridium Difficile Infection
This clinical study is conducted to assess the safety and immunogenicity of a Clostridium difficile vaccine (CDVAX) in healthy adult volunteers.
- Trial name
- CDVAX (NCT02991417)
- Testing
- CDVAX
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Simon M. Cutting
Tuberculosis
Training Lay Healthcare Workers to Optimize TB Care and Improve Outcomes in Malawi
Task shifting of less complex healthcare tasks to lay health workers (LHWs) is increasingly employed strategy to address the global shortage of skilled health workers.
- Trial name
- NCT02533089
- Testing
- KT intervention
- Where
- Malawi
- Volunteers
- 1,153 people
- Sponsor
- Dignitas International
Tuberculosis (TB)
Research on Key Interventional Technologies for Controlling the Epidemic in High-prevalence Areas of Tuberculosis in Guangxi, China
The goal of this study is to find out if using mobile vans with advanced technology can help reduce tuberculosis (TB) in rural Guangxi, China. The study will also examine how practical and cost-effective this approach is.
- Trial name
- NCT06702774
- Testing
- Active case finding
- Where
- China
- Volunteers
- 43,067 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Latent Tuberculosis Infection
Comparing Two Preventive Regimens for Latent Tuberculosis Infection (LTBI)
Though still an endemic area, the incidence of tuberculosis (TB) in Taiwan is decreasing in recent years. Further reduction in TB incidence, or even elimination should rely on treatment for LTBI.
- Trial name
- NCT01398618
- Testing
- 4-month rifampin vs. 9-month isoniazid
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Tuberculosis
The Incidence and Risk Factors of Side Effects During the Initial Phase of Rifater Therapy - a Prospective Study
Tuberculosis remains one of the largest health problems in the world today. Multidrug therapy is necessary to cure tuberculosis patients and to prevent the selection of drug-resistant mutants, however, which may increase the…
- Trial name
- NCT01182259
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- E-DA Hospital
Staphylococcus Aureus, Staphylococcal Skin Infections
Rapid Test to Detect Staphylococcus Aureus in Blood and Wound Infections
The purpose of this study is to determine whether the Cepheid GeneXpert system accurately detects Methicillin-Resistant and -Susceptible Staphylococcus aureus in blood cultures and wound swabs.
- Conditions
- Staphylococcus Aureus, Staphylococcal Skin Infections, Bacteremia
- Trial name
- NCT01198262
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Tuberculosis, Pulmonary
Epidemiologic Study to Assess the IGRA Positivity in Populations With a High TB Burden
The purpose of this study is to conduct a multi-country, multi-site, epidemiologic study designed to assess the proportion of interferon gamma release assay (IGRA) positivity, at site level, and to build capacity to conduct a…
- Trial name
- NCT05190146
- Where
- 36 sites in Bangladesh, Brazil and 12 more
- Volunteers
- 7,203 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Drug Induced Liver Injury, Tuberculosis (TB)
Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi
OBJECTIVE : To compare the outcome of treatment with silymarin or N-acetyl cysteine in patients taking anti-tuberculous drugs for tuberculosis at Tertiary Care Hospital, Karachi.
- Trial name
- NCT07058090
- Testing
- Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
- Volunteers
- 410 people
- Sponsor
- Liaquat National Hospital & Medical College
Tuberculosis, Pulmonary
Therapeutic ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB
This study is being done to test an experimental study vaccine compared to a placebo. The experimental study vaccine is called ID93 + GLA-SE.
- Trial name
- NCT06205589
- Testing
- ID93 + GLA-SE vaccine
- Volunteers
- 1,500 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Copd, Tuberculosis
Pulmonary Tuberculosis Sequelae in Patients With COPD
It is known that there is a complex relationship between tuberculosis and COPD. Post-tuberculosis airway disease or COPD associated with tuberculosis occurs in a significant portion of tuberculosis patients.
- Conditions
- Copd, Tuberculosis, Quality of Life
- Trial name
- NCT04721080
- Testing
- Functional Outcome Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Izmir Katip Celebi University
HIV/AIDS, Hypertension
Evaluating the Impact of a Community Health Worker Program in Neno, Malawi
This protocol concerns the implementation and evaluation of an intervention designed to realign the existing cadre of Community Health Workers (CHW) in Neno District, Malawi to better support the care needs of the clients they…
- Conditions
- HIV/AIDS, Hypertension, Asthma, Diabetes
- Trial name
- NCT03106727
- Testing
- Household model
- Where
- Malawi
- Volunteers
- 122,395 people, healthy volunteers welcome
- Sponsor
- Partners in Health
Pediatric HIV Infection, Tuberculosis Infection
Dolutegravir Pharmacokinetics Among HIV/TB Coinfected Children Receiving Standard and High-dose Rifampicin
Tuberculosis (TB) is the leading cause of death among children with HIV, yet insufficient data are available on the pharmacokinetics of newer HIV/TB cotreatment strategies in children.
- Trial name
- NCT05069688
- Testing
- rifampicin
- Where
- Nigeria
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
HIV/AIDS, Transitions of Care
Inpatient Package to Reduce HIV and AIDS-related Death in Zambia
Early post-discharge mortality is high among HIV-infected Zambians admitted to the hospital. Likely this is in part due to missed opportunities to identify lethal coinfections and optimize HIV care during admission (and before…
- Conditions
- HIV/AIDS, Transitions of Care, Hospitalization, Tuberculosis
- Trial name
- IPADZ (NCT04033718)
- Testing
- Inpatient lab bundling, Inpatient navigation
- Where
- Zambia
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Tuberculosis, Child Health
The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis
The Decide-TB project aims to generate evidence for the implementation of a comprehensive Treatment Decision Algorithms (TDA) based approach for TB in children living in high TB burden and resource-limited countries, at District…
- Conditions
- Tuberculosis, Child Health, HIV, Severe Acute Malnutrition
- Trial name
- DTB (NCT06593080)
- Testing
- The comprehensive TDA based approach
- Where
- 29 sites in Zambia
- Volunteers
- 30,240 people, healthy volunteers welcome
- Sponsor
- Chishala Chabala
Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection
Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial
The goal of this clinical trial is to learn if a new combination antibiotic treatment (Arm D) works to treat a rare lung condition called mycobacterium abscessus pulmonary disease in people of any age and sex, when compared to…
- Conditions
- Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Infections, Non-Tuberculous Mycobacteria Pulmonary Disease
- Trial name
- FORMaT-EVOLVE (NCT07485010)
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin
- Volunteers
- 300 people
- Sponsor
- The University of Queensland
Tuberculous Meningitis
The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis
The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.
- Trial name
- NCT02588196
- Testing
- Dexamethasone acetate
- Volunteers
- 200 people
- Sponsor
- Hui Bu
Gram-Positive Bacterial Infections
Telavancin for Treatment of Uncomplicated Staphylococcus Aureus Bacteremia
The purpose of this study is to determine whether telavancin (TD-6424, ARBELIC) can be safety administered to patients with bloodstream infections and whether telavancin is effective in treating these infections.
- Trial name
- ASSURE (NCT00062647)
- Testing
- Telavancin, Vancomycin, nafcillin, oxacillin, or cloxacillin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cumberland Pharmaceuticals
Haemophilus Influenzae Type b, Diphtheria
Safety of DTPa-IPV/Hib & DTPa-HBV-IPV/Hib, Followed by DTPa-IPV/Hib Vaccine in Infants Who Received Hepatitis B Vaccine
To assess the safety and reactogenicity of the DTPa-HBV-IPV/Hib vaccine and DTPa-IPV/Hib vaccine. This DTPa-IPV/Hib vaccine given at 3 and 4 months of age is co-administered with GSK Biologicals' rotavirus vaccine or Placebo.
- Conditions
- Haemophilus Influenzae Type b, Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT00325143
- Testing
- DTPa-HBV-IPV/Hib, DTPa-IPV/Hib vaccine
- Where
- 3 sites in Singapore
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tuberculosis (TB)
Usability mTBScreen
Building on recent developments in the sphere of digital health and data science, as well as the principles of usability engineering, we propose to assess the usability of a digital tool called mTBscreen for tuberculosis (TB)…
- Trial name
- mTBscreen (NCT07840989)
- Testing
- mTBscreen Application, Mobile phone Application
- Where
- 4 sites in Zambia
- Volunteers
- 30 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
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