Clinical trials: Greater Occipital Nerve Block
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2
Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects.
- Trial name
- NCT07796074
- Testing
- Bupivacaine bilateral greater occipital nerve block
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Posterior Fossa Tumor
Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy
Surgery within the posterior fossa is associated with the highest incidence and greatest severity of acute postoperative pain that may persist beyond the immediate postoperative period.
- Trial name
- NCT03762343
- Testing
- ultrasound guided Greater occipital nerve block, control group C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Posterior Fossa Tumor
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.
The goal of this clinical trial is to evaluate the effects of ultrasound-guided versus blind greater occipital nerve block (GONB), with or without Dexmedetomidine as an adjuvant, in pediatric patients undergoing posterior fossa…
- Trial name
- NCT07878156
- Testing
- Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Headache, Migraine
Treatment Response to GON Pulsed Radiofrequency in Elderly Patients With Chronic Migraine
Headache disorders are highly prevalent in older adults, yet their management remains challenging due to comorbidities, polypharmacy, and the paucity of evidence derived from geriatric populations.
- Trial name
- FRAIL-GON (NCT07363083)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine Disorders
Greater Occipital and Supraorbital Nerve Blockade in Migraine Patients
The investigators aimed to evaluate the efficacy of greater occipital nerve and supraorbital nerve blockade with local anesthetics for the preventive treatment of migraine without aura.
- Trial name
- NCT03435185
- Testing
- Lidocaine injections, Saline injections
- Volunteers
- 103 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Migraine
Greater Occipital Nerve Block With Bupivacaine for Acute Migraine
This is a randomized, sham-controlled study of greater occipital nerve block (GONB) using bupivacaine 0.5% for emergency department patients with acute migraine.
- Trial name
- NCT02665273
- Testing
- Greater occipital nerve block, Bupivacaine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Montefiore Medical Center
Migraine
Research Study Examining Nerve Block for Migraine
Migraine and the skin sensitivity that accompanies it can go away in minutes after a nerve block, which is a procedure involving an injection of a small amount of a local anesthetic next to a nerve to the skin, causing an area of…
- Trial name
- NCT00203346
- Testing
- Greater Occipital Nerve Block
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University
Spontaneous Intracranial Hypotension
Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension
Spontaneous Intracranial Hypotension (SIH) is a debilitating neurological disorder caused by a cerebrospinal fluid leak (CSF), with an estimated incidence of 5 per 100,000 persons per year, of which mostly women between the ages…
- Trial name
- NCT06374524
- Testing
- greater occipital nerve block
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Migraine Disorders, Medication Overuse Headache
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Migraine is among the leading causes of disability worldwide. Inappropriate use of acute medications in the setting of primary headache, particularly migraine can result in a debilitating condition known as medication overuse…
- Conditions
- Migraine Disorders, Medication Overuse Headache, Greater Occipital Nerve Block
- Trial name
- GONB_MOH (NCT07568496)
- Testing
- Lidocaine 2% and Methylprednisolone 80 mg
- Where
- 3 sites in Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Trigeminal Neuralgia
Greater Occipital Nerve and Cervical Region Injection in Patients With Trigeminal Neuralgia
The aim of this study is to investigate the efficacy of greater occipital nerve block and cervical injections with lidocaine
- Trial name
- NCT04505280
- Testing
- Lidocaine 1% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Migraine
Greater Occipital Nerve Block Versus Pulse Radiofrequency in Migraine
The aim of the study is to evaluate the clinical efficacy of the repeated greater occipital nerve(GON) blokcs with GON pulse radiofreaquency (PRF)
- Trial name
- GON-B/PRF (NCT06345326)
- Testing
- Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Adiyaman University Research Hospital
Migraine Disorders
Greater Occipital Nerve (GON) Block Effectivity in the Treatment of Chronic Migraine: 6 Months Follow up
This study evaluates effectiveness of greater occipital nerve blocks with bupivacaine compared to placebo in chronic migraine patients.
- Trial name
- GON (NCT02578719)
- Testing
- bupivacaine, saline
- Sponsor
- Bozok University
Episodic Migraine
Efficacy of Nerve Blocks for Episodic Migraine
The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose…
- Trial name
- NCT05734625
- Testing
- Bupivacaine HCl 0.5% Injectable Solution, Methylprednisolone 40 MG Injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Occipital Neuralgia, Cervicogenic Headache
Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block
This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache.
- Conditions
- Occipital Neuralgia, Cervicogenic Headache, Migraine Without Aura
- Trial name
- NCT03478735
- Testing
- Ultrasound Guided Greater Occipital Nerve Block at C2, Landmark-Based Greater Occipital Nerve Block
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Post-Dural Puncture Headache
Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache
Post-dural puncture headache is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia.
- Trial name
- NCT04844229
- Testing
- Bilateral transnasal sphenopalatine ganglion block., Bilateral ultrasound guided greater occipital nerve block.
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Cervicogenic Headache
Efficacy of Ultrasound-Guided Multifidus Cervicis Plan Block Vs Greater Occipital Nerve Block for Cervicogenic Headache
Background: Cervicogenic headache (CH) described as a chronic hemi-cranial pain resulted from a disorder of the cervical spine and its anatomic structures innervated by the C1, C2, and C3 cervical spinal nerves.
- Trial name
- UBLOC (NCT04454541)
- Testing
- Ultrasound-guided nerve block for headache management
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Abha International Private Hospital
Migraine
Predictors of GON Blockade Success in Migraine
This multicenter, prospective cohort study aims to identify clinical and demographic predictors that influence the success of greater occipital nerve (GON) block in patients with migraine.
- Trial name
- NCT07170111
- Testing
- Greater Occipital Nerve (GON) Blockade
- Where
- Turkey (Türkiye)
- Volunteers
- 460 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Postdural Puncture Headache
Greater Occipital Nerve Block Value in Management of Postdural Puncture Headache
Neuraxial techniques are well tolerated and effective options for labor analgesia and anesthesia for caesarean section, and may protect high risk women against severe maternal morbidity.
- Trial name
- NCT06380764
- Testing
- Greater Occipital Nerve Block, Bilateral suboccipital intramuscular injection, Epidural Blood Patch
- Where
- Egypt
- Volunteers
- 152 people
- Sponsor
- Benha University
Chronic Migraine Headache, Radiofrequency Ablation
The Effect of Interventional Procedures on Serum CGRP and PACAP-38 Levels in Chronic Migraine
The study included 100 patients diagnosed with chronic migraine (CM) who received a diagnosis from the headache clinics of the Neurology Department of Adnan Menderes University Hospitals between May 2025 and May 2026.
- Conditions
- Chronic Migraine Headache, Radiofrequency Ablation, Greater Occipital Nerve Block, Calcitonin Gene-related Peptide
- Trial name
- NCT07395908
- Testing
- Greater occipital nerve Pulse radiofrequency, Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Chronic Migraine
GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study
Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache.
- Trial name
- DHC-GON-1 (NCT02686983)
- Testing
- Betamethasone and local anesthetic
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Jakob Møller Hansen, MD.