Clinical trials: Group Identification, active
Osteoporosis, Osteopenia
Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures
Osteoporosis (OP) is one of most common age-associated and chronic metabolic bone diseases, featured by a decrease of bone mineral density (BMD) that increases the risk of bone fractures.OP guidelines agree that Dual-X-ray…
- Conditions
- Osteoporosis, Osteopenia, Osteoporosis Fracture
- Trial name
- DISCERN (NCT06551155)
- Testing
- Vitality and biological activity of peripheral blood mononuclear cells (PBMCs)
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cardiovascular Diseases, Malignancy
Identification of Risk Factors for Cardiovascular Disease and Cancer in Korean Population: A Prospective Cohort Study
Cancer and cardiovascular disease are the global leading causes of death. These two disease entities are multifactorial disease that are caused by several factors.
- Conditions
- Cardiovascular Diseases, Malignancy, Risk Factor
- Trial name
- NCT05389956
- Where
- South Korea
- Volunteers
- 510,000 people, healthy volunteers welcome
- Sponsor
- Ulsan University Hospital
Cervical Cancer, Transgender Persons
Gynecology Beyond Gender: Cervical Cancer Screening in Transgender Men in France
In France, cervical cancer screening is the subject of a national screening programme organized for all asymptomatic individuals aged 25 to 65 years with a cervix.
- Conditions
- Cervical Cancer, Transgender Persons, Health Services for Transgender Persons
- Trial name
- GYDECAT (NCT05924217)
- Testing
- Survey questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Type2diabetes
Early Identification of Heart Failure in a High-Risk Diabetic Cohort
Type 2 diabetes is an important co-morbid condition strongly associated with the risk of developing heart failure (HF). Risk scores such as the WATCH-DM score that predict the occurrence of HF among diabetes patients are largely…
- Trial name
- NCT05866380
- Testing
- heart failure risk factors
- Where
- Taiwan
- Volunteers
- 3,500 people
- Sponsor
- Mackay Memorial Hospital
Cutaneous Melanoma, Mucosal Melanoma
Neo IRENIE (NEOadjuvant Ipilimumab, RElatlimab, NIvolumab Evaluation)
This clinical trial is for patients with stage 3 cutaneous melanoma and patients with mucosal melanoma who are able to have surgery to remove all tumour deposits.
- Trial name
- Neo IRENIE (NCT06999980)
- Testing
- Ipilimumab 3mg/kg and nivolumab 1mg/kg, Ipilimumab 1mg/kg Nivolumab 480mg and relatlimab 160mg, Nivolumab 480mg and relatlimab 160mg
- Where
- Australia
- Volunteers
- 494 people
- Sponsor
- Melanoma Institute Australia
Hepatocellular Carcinoma, Hepatitis B
Discovering Urinary Protein Biomarkers for Hepatocellular Carcinoma in Chronic Hepatitis B Population
Chronic hepatitis B (CHB) can lead to hepatocellular carcinoma (HCC), imposing a significant health and economic burden globally.
- Trial name
- NCT06379334
- Testing
- Urine test
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Alzheimer Disease, Preclinical Alzheimer
β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline
The overall (cross-sectional) objective of this study is to detect and describe the profile of AD-related blood biomarkers in a population with SCD (including individuals with MCI) with the ultimate goal of investigating their…
- Conditions
- Alzheimer Disease, Preclinical Alzheimer, Mild Cognitive Impairment
- Trial name
- β-AARC (NCT04935372)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Outpatients With Chronic Heart Failure, Heart Failure Chronic
Biomarker Panel Development for Early Identification of Worsening Heart Failure and Improved Post-acute Care
Heart failure is a complex clinical syndrome with high hospitalization rates and high mortality risks. While N-terminal-pro B-type natriuretic peptide (NT-proBNP) is widely used in clinical practice to assist in diagnosis and…
- Trial name
- NCT07838766
- Volunteers
- 800 people
- Sponsor
- Chang Gung Memorial Hospital
Forensic Psychiatric Patients, Not Guilty by Reason of Insanity (NGRI)
Factors of Effectiveness in Italian Forensic Treatment
Over recent years, in Italy, the treatment of mentally ill offenders has undergone profound changes following successive legislative interventions, culminating in Law no.
- Conditions
- Forensic Psychiatric Patients, Not Guilty by Reason of Insanity (NGRI), Incompetent to Stand Trial (IST), Psychotic Disorders
- Trial name
- REMS FEIFT (NCT06854133)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Bari
Ovarian Cancer
Ovarian Cancer Identification on CT Using Deep Learning
Ovarian cancer remains the deadliest gynecologic malignancy, with poor survival rates largely due to late-stage diagnosis. Early detection is crucial, yet no universally accepted screening method exists.
- Trial name
- NCT06851429
- Where
- 2 sites in Taiwan
- Volunteers
- 12,578 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
COPD
A Translational Study for Prediction of Biomarkers and Identification of Phenotype and Endotype of COPD and Pre-COPD Outcomes in Chinese Population
This is an observational study into more comprehensive understanding, including the trajectories of lung function decline, inflammatory/immunological mechanisms on pre-COPD or PRISm, clinical outcomes and relevant endotypes on…
- Trial name
- NCT06724848
- Where
- 14 sites in China
- Volunteers
- 850 people
- Sponsor
- AstraZeneca
ATTR-CM
Implementation of Standardized Early Identification and Diagnosis for Transthyretin Amyloidosis (ATTR) in High-Risk Populations
This multicenter, prospective, single-arm, interventional study will enroll about 4,000 adult patients at high risk of ATTR amyloidosis from around 50 sites in China.
- Trial name
- NCT07338942
- Testing
- implementation of standard early identification and diagnosis of ATTR
- Where
- 48 sites in China
- Volunteers
- 4,000 people
- Sponsor
- AstraZeneca
Cancer, Genetic Predisposition
EXOME Analysis Position in the Strategy of Genetic Predisposition Factors Identification in Early-onset Cancer
5 to 10% of cancers are due to the presence of a constitutional genetic alteration. It can be inherited from parents (family form) or by accident, in the first moments of life after fertilization (sporadic form).
- Trial name
- EX²TRICAN (NCT04141462)
- Testing
- blood sample
- Where
- 6 sites in France
- Volunteers
- 613 people
- Sponsor
- Centre Georges Francois Leclerc
Congenital Diaphragmatic Hernia
Engagement in Physical Activities and Sports in Adolescents With Diaphragmatic Hernia
The objective is to understand how a population of adolescents - who have undergone diaphragm surgery within their first month of life (i.e.
- Trial name
- CHASAM (NCT05666986)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Non-small Cell Lung Cancer (NSCLC)
Analysis of Whole Exome and Transcriptome Sequencing to Identify Prognostic Biomarkers in Patients With Non-Small Cell Lung Cancer (NSCLC)
This is a non-interventional translational research study aiming to comprehensively characterize the genomic and transcriptomic landscape of patients with non-small cell lung cancer (NSCLC).
- Trial name
- EXPLORE (NCT07900581)
- Where
- 20 sites in Cyprus, Greece
- Volunteers
- 300 people
- Sponsor
- Hellenic Cooperative Oncology Group
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Respiratory Pathogens
Prospective Study of Multi-centers Exploring the Difference of Clinical Impact by Using Respiratory Pathogen ID/AMR Panel (RPIP) Versus Untarget Metagenomic Next-generation Sequencing (mNGS) and Multiplex PCR in Pathogen Identification of Pneumonia Patients in Intensive Care Unit
Pneumonia, pathogen involved to lower respiratory tract and leading lung parenchyma infection, is one of the three most common infectious diseases in the world.
- Trial name
- NCT07626073
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- China Medical University Hospital