Clinical trials: Growth
Infant, Premature, Diseases, Bronchopulmonary Dysplasia
Growth of Airways and Lung Tissues in Premature and Healthy Infants
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Infant, Premature, Diseases, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00419588
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Indiana University
Chronic Tympanic Membrane Perforation
In-office Repair of Chronic Tympanic Membrane Perforations
The goal of this clinical trial is to compare the application of fibroblast growth factor 2 (FGF2) with normal saline for the healing of chronic tympanic membrane (TM) perforations. This is an extension of a prior study.
- Trial name
- NCT06448039
- Testing
- Fibroblast Growth Factor 2, Saline control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- D. Bradley Welling, MD, PhD
Growth
Preterm Infants Fed a Human Milk Fortifier
This is a double-blind, randomized, multi-center, controlled, parallel study to evaluate the growth and tolerance of preterm infants fed human milk fortifier (HMF).
- Trial name
- NCT05551975
- Testing
- Control Product, Experimental Product 1, Experimental Product 2
- Where
- 14 sites in United States
- Volunteers
- 321 people
- Sponsor
- Abbott Nutrition
Advanced Solid Tumor, Gynecologic Cancer
A Study of PY314 in Subjects With Advanced Solid Tumors
This is an open-label, multicenter, first in human, Phase 1a/1b study of PY314 in subjects with locally advanced (unresectable) and/or metastatic solid tumors that are refractory or relapsed to standard of care (including…
- Conditions
- Advanced Solid Tumor, Gynecologic Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT04691375
- Testing
- PY314, Combination Therapy: PY314 + Pembrolizumab
- Where
- 23 sites in United States
- Volunteers
- 86 people
- Sponsor
- Ikena Oncology
Neurodevelopmental Disorders, Lactation
Iron Supplement Effect on Child Development
Objective: To evaluate the effect of Iron supplement with two different amounts (one in the higher limit and another in the lower limit of the suggested amount) according to the presence of mutations in the HFE gene in the…
- Trial name
- NCT02690675
- Testing
- Iron fortified formula milk
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Metastatic Breast Cancer, Locally Advanced Breast Cancer
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
The main purpose of this research study is to learn whether the investigational combination of olaparib, palbociclib, and fulvestrant is safe in patients with estrogen receptor-positive breast cancer and BRCA1 or BRCA2 mutations.
- Conditions
- Metastatic Breast Cancer, Locally Advanced Breast Cancer, Advanced Breast Cancer, BRCA2 Mutation
- Trial name
- NCT03685331
- Testing
- Palbociclib, Olaparib, Fulvestrant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Advanced Cancer, Advanced Malignancies
Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies
This is a phase 1, open-label, multicenter, ascending-dose escalation study of cemiplimab, alone and in combination with other anti-cancer therapies in patients with advanced malignancies.
- Trial name
- NCT02383212
- Testing
- Cemiplimab, Hypofractionated radiotherapy, Cyclophosphamide
- Where
- 47 sites in United States, Australia and 1 more
- Volunteers
- 398 people
- Sponsor
- Regeneron Pharmaceuticals
Wound Healing, Surgical Wound
Evaluating rhPDGF-BB-Enhanced Wound Matrix for Head and Neck Reconstruction
Skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma lesions that develop on the head and neck are treated by Mohs surgery or wide local excision to remove all tumor cells and preserve the…
- Trial name
- NCT06634030
- Testing
- RhPDGF-BB, Saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer
Cetuximab in Treating Patients With Stage IV Colorectal Cancer
RATIONALE: Monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00020930
- Testing
- cetuximab
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Transverse Cerebellar Diameter, Abdominal Circumference Ratio
Transverse Cerebellar Diameter and Abdominal Circumference Ratio Versus Mid-Thigh Circumference and Femur Length Ratio in Assessment of Gestational Age in Normal and Growth Restricted Fetuses
The aim of this research was to examine the accuracy of transcerebellar diameter to abdominal circumference ratio (TCD/AC) and mid-thigh circumference and femur length (MTC/FL) in estimating the gestational age of healthy and…
- Conditions
- Transverse Cerebellar Diameter, Abdominal Circumference Ratio, Mid-Thigh Circumference and Femur Length Ratio, Gestational Age
- Trial name
- NCT07675902
- Testing
- Fetal Ultrasound Assessment
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Gastric Cancer
Her 2 Testing in Indian Patients With Gastric Cancer
Gastric cancer remains a major health issue and a leading cause of cancer death worldwide, although the prevalence and mortality of the disease have gradually decreased.
- Trial name
- NCT01814345
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Hospital
Adrenal Insufficiency, Osteopenia, Osteoporosis
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study
Bone disease and adrenal suppression are two of the many side effects of steroid use in pediatrics. Evidence has shown that adrenocorticotropic hormone (ACTH) protects against the adverse bone effects of steroids in animals and…
- Conditions
- Adrenal Insufficiency, Osteopenia, Osteoporosis, Steroid Suppression of ACTH Secretion
- Trial name
- NCT03709381
- Testing
- Low Dose Cosyntropin (ACTH) stimulation test, High Dose Cosyntropin (ACTH) stimulation test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Dry Eye Syndrome
Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye
The primary objective of this study was to assess the efficacy and safety of different doses of rhNGF when administered as eye drops to patients with dry eye.
- Trial name
- NCT02101281
- Testing
- rhNGF 20 µg/mL, rhNGF 4 µg/mL
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Dompé Farmaceutici S.p.A
Melanoma (Skin)
PEG-Interferon Alfa-2b in Treating Patients With Stage IV Melanoma
RATIONALE: Peginterferon (PEG-interferon) alfa-2b may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: Phase II trial to study the effectiveness of PEG-interferon alfa-2b in treating patients who have stage…
- Trial name
- NCT00049530
- Testing
- PEG-interferon alfa-2b
- Where
- 32 sites in United States
- Volunteers
- 32 people
- Sponsor
- Eastern Cooperative Oncology Group
Growth and Development
Validation of a Smart Phone App to Non-invasively Measure the Size of Children
Smart phones are omnipresent. Apps exist to calculate size of medical equipment and doses of medication if a valid weight or age is entered. During emergency situations, these values are often unknown.
- Trial name
- NCT02805192
- Testing
- Size Measurement by a Smart phone App
- Where
- Switzerland
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Anorexia Nervosa
Influence of Protein Supplements on Serum Insulin-like Growth Factor-I Levels in Women With Anorexia Nervosa
This multicentre, randomised, double-blind, 2-parallel group, controlled trial aims to investigate whether oral milk protein supplements led to increase in serum Insulin-like Growth Factor-I levels (IGF-I) as compared with a…
- Trial name
- NCT01823822
- Testing
- Oral protein supplement (Tested product), Iso-caloric supplement (Control product)
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- University Hospital, Geneva
Coronary Artery Disease (CAD)
Predicting Plaque Growth Using Blood Flow Stress Markers: A Proof-of-Concept Study
Coronary artery disease occurs when fatty deposits (plaques) build up inside the arteries that supply blood to the heart. Some plaques remain stable, while others continue to grow or become more likely to rupture, which can lead…
- Trial name
- POSSEM (NCT07864051)
- Testing
- PCCTA scan, Endothelial cell isolation from peripheral blood sample
- Where
- United Kingdom
- Volunteers
- 270 people
- Sponsor
- Queen Mary University of London
Advanced Solid Tumors
Safety Study of IMC-18F1,to Treat Advanced Solid Tumors in Subjects That no Longer Respond to Standard Therapy
The purpose of this study is to determine if IMC-18F1 is safe for patients, and also to determine the best dose of IMC-18F1 to give to patients.
- Trial name
- NCT00782002
- Testing
- IMC-18F1
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Eli Lilly and Company
Carcinoma, Non-Small-Cell Lung
A Study Comparing Pemetrexed Plus Cisplatin Versus Pemetrexed Alone in NSCLC Patients Who Have Progressed on First Line EGFR-TKI
It has not been established whether platinum-based doublets is better than single agent chemotherapy in EGFR mutant NSCLC patients who failed first-line EGFR TKI.
- Trial name
- NCT03050437
- Testing
- Cisplatin, Pemetrexed
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Safety and Efficacy of SCT200 in Head and Neck Squamous Cell Carcinoma
The purpose of this study is to evaluate the efficacy and safety of recombinant anti-EGFR monoclonal antibody（SCT200）in patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma after failure of…
- Trial name
- NCT03713372
- Testing
- Anti-EGFR monoclonal antibody
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sinocelltech Ltd.