Clinical trials: Growth Disorder
Congenital Diseases, Diaphragmatic Hernia
Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia
This trial investigates whether prenatal intervention improves survival rate of fetuses with isolated congenital diaphragmatic hernia and severe pulmonary hypoplasia, as compared to expectant management during pregnancy, both…
- Conditions
- Congenital Diseases, Diaphragmatic Hernia, Pulmonary Hypoplasia
- Trial name
- TOTAL (NCT01240057)
- Testing
- fetal endoluminal tracheal occlusion, watchful waiting during pregnancy
- Where
- 12 sites in United States, Australia and 9 more
- Volunteers
- 93 people
- Sponsor
- University Hospital, Gasthuisberg
Androgenetic Alopecia, Pattern Baldness
Evaluation of the Niostem Headset for Hair Growth and Hair Quality
This double-blind, randomized, placebo-controlled clinical trial evaluates the Niostem headset, an electronic device designed to support hair growth, reduce hair loss, and improve hair quality.
- Trial name
- NCT06994819
- Testing
- niostem headset (Active)
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mane Biotech GmbH
Childhood-onset Growth Hormone Deficiency, Pituitary Dwarfism
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency
The primary objective is to evaluate the efficacy and safety of two different dose regimens of r-hGH (Saizen®) in subjects with childhood-onset growth hormone deficiency (COGHD) during the transition phase from childhood to…
- Trial name
- NCT00109733
- Testing
- recombinant human growth hormone
- Where
- 9 sites in United States
- Volunteers
- 31 people
- Sponsor
- EMD Serono
Macular Edema Due to Type 2 Diabetes Mellitus
Efficacy Analysis of Anti-VEGF Drugs Combined With Micropulse Laser in the Treatment of Diabetic Macular Edema
The goal of this clinical trial is to clarify the efficacy of anti-vascular endothelial growth factor (anti-VEGF) drugs combined with subthreshold micropulse laser (SML) therapy on retinal function and anatomical recovery in…
- Trial name
- VEGF (NCT05759884)
- Testing
- Anti-VEGF, subthreshold micropulse laser
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Psychosocial Adjustment
Endocrine and Psychological Evaluation of Adopted Children
The deleterious effects of institutionalized care on the health and growth and development of children have been described. Early studies have shown that the effects of institutionalized care on a child's growth and development…
- Trial name
- NCT00368043
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Macular Edema (ME)
To Assess the Efficacy and Safety of Intravitreal Ranibizumab in People With Vision Loss Due to Macular Edema
To evaluate the efficacy and safety of 0.5 mg Ranibizumab intravitreal injections in adult patients with visual impairment due to macular edema (ME).
- Trial name
- NCT01846299
- Testing
- Ranibizumab
- Where
- 61 sites in Australia, Belgium and 17 more
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
Youth Mental Health, Anxiety
Using Conversational AI to Teach Growth Mindset Skills to Youths in India
This study aims to test whether a brief digital intervention using conversational AI can improve mental health outcomes among school-aged youth (grades 6-8) in India, where most young people with mental health issues do not…
- Conditions
- Youth Mental Health, Anxiety, Depression
- Trial name
- NCT07316647
- Testing
- Growth mindset training using conversational AI
- Where
- India
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Harvard University
Lung Cancer
Gefitinib Usage and Outcomes in Routine Treatment
The purpose of this study is to understand real world gefitinib usage patterns, patient characteristics and outcomes and to present these for a Caucasian population
- Trial name
- NCT01818947
- Where
- 12 sites in United Kingdom
- Volunteers
- 157 people
- Sponsor
- AstraZeneca
HER2-positive Breast Cancer
Anti-HER2 Therapy + Fulvestrant/Capecitabine in Women With HR+, HER2+, Non-visceral Metastases Stage IV Breast Cancer
The purpose of this study is to evaluate the effectiveness of anti-HER2 therapy plus Fulvestrant or Capecitabine in women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 positive (HER2+)…
- Trial name
- FAVOR (NCT04337658)
- Testing
- Pertuzumab, Trastuzumab, Fulvestrant
- Where
- 2 sites in China
- Volunteers
- 493 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate Cancer
Study of PTK787 in the Treatment of Patients With Non-Metastatic Androgen Independent Prostate Cancer
The purpose of this study is to evaluate PTK787/ZK 222584, a drug that blocks new blood vessel growth, in the treatment of patients with non-metastatic androgen independent prostate cancer.
- Trial name
- NCT00134355
- Testing
- PTK787
- Volunteers
- 5 people
- Sponsor
- University of Michigan Rogel Cancer Center
Hypoxic-Ischaemic Encephalopathy, Neonatal Encephalopathy
Intranasal Breast Milk Therapy in HIE
This is an open-label prospective single-center randomized controlled trial to evaluate the effect of intranasal breast milk in hypoxic-ischemic encephalopathic neonates receiving therapeutic hypothermia on long term…
- Conditions
- Hypoxic-Ischaemic Encephalopathy, Neonatal Encephalopathy, Perinatal Asphyxia, Neonatal Hypoxic Ischemic Encephalopathy
- Trial name
- NEO-BRIGHT (NCT06746532)
- Testing
- Intranasal breast milk
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Semmelweis University
Cardiovascular Diseases, Heart Diseases
National Growth and Health Study (NGHS)
To determine if the Black-white differences in the development of obesity in pubescent females were due to differences in psychosocial, socioeconomic and other environmental factors.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Coronary Disease
- Trial name
- NCT00005132
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Estrogen Receptor Negative Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple Negative Metastatic Breast Cancer
This phase I/II trial study evaluates the tolerability and best tolerated dose of the PI3K inhibitor GDC-0941 when given with the chemotherapy cisplatin.
- Conditions
- Estrogen Receptor Negative Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Triple Negative Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01918306
- Testing
- cisplatin, laboratory biomarker analysis, pharmacological study
- Where
- 16 sites in United States
- Volunteers
- 11 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breastfeeding, Postnatal Depression
Mother and Late Preterm Lactation Study
Breastfeeding has various benefits for the mother and infant. It has the capability of reducing the risk of short term and long term problems for the infant, such as gastroenteritis, respiratory infections, type II diabetes and…
- Conditions
- Breastfeeding, Postnatal Depression, Stress, Psychological, Preterm Infant
- Trial name
- MAPLeS (NCT03791749)
- Testing
- Breastfeeding Support
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College, London
Leukemia, Lymphoma
Pharmacokinetic Study of Palifermin in Subjects Receiving Radiation Therapy and Chemotherapy Followed by Blood Stem Cell Support
Open label palifermin will be administered to subjects who are at a risk of developing mucositis after radiotherapy and chemotherapy followed by blood stem cell support.
- Conditions
- Leukemia, Lymphoma, Myeloma
- Trial name
- NCT00070616
- Testing
- Palifermin 6 x 60 μg/kg/day, Palifermin 2 x 180 μg/kg/day, radiotherapy
- Volunteers
- 25 people
- Sponsor
- Swedish Orphan Biovitrum
Advanced Non Small Cell Lung Cancer
Almonertinib Plus Microwave Ablation in Advanced Non-small Cell Lung Cancer
Almonertinib, as a third-generation EGFR-TKI, has been used for the treatment of advanced non small cell lung cancer. How to improve the progression free survival in advance was a challenge.
- Trial name
- MWA (NCT04755738)
- Testing
- Almonertinib plus microwave ablation
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Qianfoshan Hospital
Intermittent Fasting, Metabolic Dysfunction-Associated Fatty Liver Disease
Intermittent Fasting and Metabolic Dysfunction Associated Fatty Liver Disease
Previous studies have investigated the effect of different dietary patterns on metabolic dysfunction-associated fatty liver disease (MAFLD), for which lifestyle modification remains the primary treatment.
- Trial name
- NCT06664684
- Testing
- Energy-restricted dietary intervention, Energy + time-restricted dietary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Gastric Adenocarcinoma
Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma
The purpose of this study was to evaluate the efficacy of derazantinib monotherapy or derazantinib in combination with paclitaxel and ramucirumab in patients with gastric adenocarcinoma (GAC) i.e.
- Trial name
- FIDES-03 (NCT04604132)
- Testing
- Derazantinib, Derazantinib-paclitaxel-ramucirumab combination
- Where
- 81 sites in United States, Argentina and 13 more
- Volunteers
- 47 people
- Sponsor
- Basilea Pharmaceutica
Endocrine System Diseases
Treatment With Recombinant Human Growth Hormone (GH) in Children With Short Stature Secondary to a Long Term Corticoid Therapy
To assess the effect of a long-term treatment by Genotonorm on linear growth in children with short stature receiving steroid therapy To assess the effect of a long term treatment with Genotonorm on bone mineralisation To assess…
- Trial name
- NCT00174187
- Testing
- Somatropin
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Pfizer
Lung Cancer
MK-0646, Etoposide, and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Monoclonal antibodies, such as MK-0646, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00869752
- Testing
- anti-IGF-1R recombinant monoclonal antibody MK-0646, cisplatin, etoposide
- Where
- 3 sites in Canada
- Volunteers
- 12 people
- Sponsor
- NCIC Clinical Trials Group