Clinical trials: Gulf War
Gulf War Illness
OEA for Targeting Lipid Metabolism in GWI
The study is a single site, randomized, double-blind, placebo-controlled study with an open label extension to evaluate the effects of Oleoylethanolamine (OEA) on blood lipid and immune biomarkers in participants with Gulf War…
- Trial name
- NCT05252949
- Testing
- Oleoylethanolamide (OEA)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Gulf War Illness
Nicotinamide Riboside Clinical Trial for GWI
In this multi-site trial, we will use a randomized, double-blind, placebo-controlled study design to test whether 300 mg of Nicotinamide Riboside (NR) can achieve the primary objective of increasing plasma NAD+ levels in…
- Trial name
- NCT05243290
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Roskamp Institute Inc.
Gulf War Syndrome, Gulf War Illness
Validating Gulf War Illness Blood Biomarkers
The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI.
- Trial name
- NCT05736146
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Gulf War Syndrome
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum…
- Trial name
- NAC (NCT04987775)
- Testing
- N-Acetyl Cysteine
- Where
- 7 sites in United States
- Volunteers
- 170 people
- Sponsor
- Nova Southeastern University
Gulf War Illness
Study of Bacopa in Gulf War Illness Patients
Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances…
- Trial name
- NCT04927338
- Testing
- BacoMind® (Bacopa monnieri standardized extract)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Nova Southeastern University
Gulf War Illness
Identification of Gulf War Illness (GWI) Biomarkers
The scientists working on this study want to use blood samples to identify components in blood, such as protein, lipids and their breakdown products to determine if they can be used for diagnosing Gulf War Illness (GWI).
- Trial name
- NCT03082638
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Roskamp Institute Inc.
Gulf War Syndrome
Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness.
The goal of this study is to investigate long-term modulation of pain pathways leading to a suppression of pain symptoms in Gulf War Illness patients by applying transcranial direct current stimulation.
- Trial name
- NCT03547869
- Testing
- Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas at Dallas
Gulf War Illness
Effects of Botanical Microglia Modulators in Gulf War Illness
The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques.
- Trial name
- NCT02909686
- Testing
- Boswellia Serrata, Curcumin, Epimedium
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Syndrome
Assessing Neuroinflammation in GWI Using MRS
The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation.
- Trial name
- NCT04638998
- Testing
- Magnetic Resonance Spectroscopic Imaging, Blood draw
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gulf War, Fatigue
Groups for Regaining Our Wellbeing
This study is a randomized clinical trial measuring outcomes up to 6-months post-intervention. The objective of this study is to evaluate outcomes of two different group interventions for Veterans with Chronic Multisymptom…
- Conditions
- Gulf War, Fatigue, Pain, Depression
- Trial name
- GROW (NCT03058952)
- Testing
- Mindfulness-Based Stress Reduction, Chronic Disease Self-Management Program
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- VA Office of Research and Development
Gulf War Veterans' Illness
CAM in Veterans With Gulf War Illnesses
The purpose of this study is to explore the effectiveness Gulf War Health Education (GWHE) and iRest Yoga Nidra (mindfulness meditation)/auricular (ear) acupuncture for Veterans with Gulf War Veterans' Illnesses (GWVI).
- Trial name
- GW-CAM (NCT02180243)
- Testing
- Mindfulness meditation/Acupuncture, Gulf War Health Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome, Gulf War Illness
Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms
This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain.
- Conditions
- Gulf War Syndrome, Gulf War Illness, Headache, Muscle Pain
- Trial name
- NCT04182659
- Testing
- Transcranial Magnetic Stimulation
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Veterans Medical Research Foundation
Gulf War Syndrome, Persian Gulf Syndrome
Mitochondrial Cocktail for Gulf War Illness
The purpose of this study is to develop preliminary evidence, such as effect size and variance estimates, to guide successful conduct of a properly-powered clinical trial to assess the benefit of a mitochondrial cocktail…
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorders
- Trial name
- NCT02804828
- Testing
- Individualized mitochondrial cocktail
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Diego
Gulf War Illness, Chronic Fatigue
Coenzyme Q10 Phase III Trial in Gulf War Illness
The primary objective of this clinical trial is to determine if treatment with ubiquinol, a form of coenzyme Q10, improves the physical function of men and women Veterans suffering from Gulf War Illness (GWI).
- Conditions
- Gulf War Illness, Chronic Fatigue, Ubiquinol, Coenzyme Q10
- Trial name
- NCT02865460
- Testing
- Ubiquinol
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome
Ketamine in Veterans With Gulf War Illness
Up to one third of the 700,000 U.S. military veterans of the 1990-91 Gulf War have Gulf War Illness (GWI), a symptom complex characterized by a combination of chronic pain, cognitive impairment, debilitating fatigue…
- Trial name
- NCT04712071
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Gulf War Illness
Research Examining Gulf War Illness in Our Nations Service Members
At least 1 in 4 of the 700,000 U.S. Veterans who served in the 1990-1991 Gulf War suffer from Gulf War Illness (GWI). Despite considerable research, effective treatments remain elusive.
- Trial name
- REGIONS (NCT01846182)
- Testing
- Duloxetine, Pregabalin
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness, Insomnia
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Sleep disturbance is a common complaint of Veterans with Gulf War Illness (GWI). Because there is clinical evidence that sleep quality influences pain, fatigue, mood, cognition, and daily functioning, this study will investigate…
- Trial name
- CBTi GWI (NCT02782780)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome
Glutamate Neuro-Excitotoxicity in GWI
The objective of the proposed research is to examine whether dietary exposure to food additives containing glutamate may be contributing to symptoms in Gulf War Illness (GWI).
- Trial name
- GWI (NCT03342482)
- Testing
- Low-glutamate diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- American University
Gulf War Illness
Cognitive Rehabilitation for Gulf War Illness
There are almost 700,000 Gulf War Veterans (GWV) with 25-30% suffering from a devastating multi-symptom illness coined Gulf War Illness (GWI).
- Trial name
- NCT02161133
- Testing
- Problem-Solving Therapy, Health Education
- Where
- 3 sites in United States
- Volunteers
- 268 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness
Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness
Gulf War Illness (GWI) is a multi-symptom disorder that is characterized by complex traits such as fatigue, headaches, joint pain, insomnia, and memory problems.
- Trial name
- NCT02915237
- Testing
- Concord grape juice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai