Clinical trials: Gulf War
Gulf War Illness
Nicotinamide Riboside Clinical Trial for GWI
In this multi-site trial, we will use a randomized, double-blind, placebo-controlled study design to test whether 300 mg of Nicotinamide Riboside (NR) can achieve the primary objective of increasing plasma NAD+ levels in…
- Trial name
- NCT05243290
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Roskamp Institute Inc.
Gulf War Illness
Probiotic (VSL #3) for Gulf War Illness
The overall objective is to determine whether VSL #3 will improve 1) intestinal symptoms of Irritable Bowel Syndrome (IBS) and 2) non-intestinal symptoms (fatigue, joint pain, insomnia, general stiffness and headache) associated…
- Trial name
- NCT02011542
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Utah
Gulf War Illness
Trial of Naltrexone and Dextromethorphan for Gulf War Illness
Veterans of the 1991 Gulf War who developed Gulf War Illness are being studied. Treatments with FDA approved generic drugs are being administered to see if they help with the symptoms of Gulf War Illness, such as chronic fatigue…
- Trial name
- GWI Treatment (NCT02206490)
- Testing
- naltrexone, Dextromethorphan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- East Carolina University
Gulf War Illness
Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness
The Gulf War Synergy Trial will evaluate the safety and efficacy of a currently available medication, methylphenidate (Ritalin®), combined with a GWI Nutrient Formula (K-PAX Synergy) to treat Gulf War Illness (GWI).
- Trial name
- NCT02357030
- Testing
- Methyl-P plus GWI Nutrient Formula
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- K-PAX Pharmaceuticals, Inc.
Gulf War Syndrome
Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness
The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage.
- Trial name
- NCT07266571
- Testing
- Pycnogenol, 100mg, Pycnogenol, 200mg, Pycnogenol, 400mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Irritable Bowel Syndrome
Effect of Diet on Gulf War Illness
Fermentable Oligo-, Di and Mono-saccharides And Polyols (FODMAPs) are carbohydrates that are poorly digested in intestines. The undigested carbohydrates are fermented in the colon by gut bacteria.
- Trial name
- NCT02881944
- Testing
- Low FODMAP Diet, High FODMAP Diet
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ashok Tuteja
Chronic Multisymptom Illness in Gulf War Veterans
A Controlled Trial of Mifepristone in Gulf War Veterans With Chronic Multisymptom Illness
We propose to conduct placebo-controlled trial of the glucocorticoid receptor antagonist mifepristone in Gulf War veterans (GWV) with chronic multisymptom illness (CMI) to examine its effects on physical and mental health and…
- Trial name
- NCT00691067
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Gulf War Syndrome
Glutathione vs. Curcumin Clinical Trial
The investigator proposes to perform a phase I/II study comparing two nutraceuticals and placebo that target mediators identified in the investigator's prior dynamic modeling study of Gulf War Illness (GWI).
- Trial name
- Glutathione (NCT02848417)
- Testing
- Curcumin, Glutathione
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- South Florida Veterans Affairs Foundation for Research and Education
Gulf War Syndrome
Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness.
The goal of this study is to investigate long-term modulation of pain pathways leading to a suppression of pain symptoms in Gulf War Illness patients by applying transcranial direct current stimulation.
- Trial name
- NCT03547869
- Testing
- Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas at Dallas
Gulf War Syndrome, Headache
Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS
This study aims to assess the effect of repetitive transcranial magnetic stimulation (rTMS) on Gulf War illness related headaches and pain.
- Trial name
- NCT03030794
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Gulf War Illness
Probiotic (Visbiome) for Gulf War Illness
The overall objective is to determine whether Visbiome will improve 1. intestinal symptoms of Irritable Bowel Syndrome (IBS) and 2.
- Trial name
- NCT03078530
- Testing
- Visbiome, VSL#3
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ashok Tuteja
Gulf War Illness
Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness
Gulf War Illness (GWI) is a multi-symptom disorder that is characterized by complex traits such as fatigue, headaches, joint pain, insomnia, and memory problems.
- Trial name
- NCT02915237
- Testing
- Concord grape juice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gulf War Syndrome
START & STOPP in GWI
Gulf War Illness (GWI) veterans were divided into 2 pathophysiological groups based on their orthostatic tachycardia responses after submaximal exercise.
- Trial name
- START (NCT03560830)
- Testing
- 2 submaximal exercise stress tests
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Gulf War Syndrome, Gulf War Illness
Confirmation of Diet as a Treatment for Gulf War Illness
This clinical trial aims to confirm previous findings from a smaller study which demonstrated significant improvements in all symptoms among veterans with Gulf War Illness after one month on the dietary intervention.
- Trial name
- NCT05675878
- Testing
- Dietary Intervention
- Where
- 3 sites in United States
- Volunteers
- 111 people
- Sponsor
- American University
Gulf War Syndrome, Chronic Fatigue Syndrome
Hyporeactivity and Gulf War Illness
This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation.
- Conditions
- Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
- Trial name
- NCT00100412
- Testing
- Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gulf War Syndrome, Persian Gulf Syndrome
Coenzyme Q10 for Gulf War Illness: A Replication Study
The purpose of this study is to assess whether a high quality preparation of ubiquinone (coenzyme Q10) benefits symptoms, function, and quality of life in veterans with Gulf War illness.
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorder, Respiratory Chain
- Trial name
- NCT06515184
- Testing
- PharmaNord Bio-Quinone Active CoQ10 Gold 100mg
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of California, San Diego
Gulf War Syndrome, Persian Gulf Syndrome
Mitochondrial Cocktail for Gulf War Illness
The purpose of this study is to develop preliminary evidence, such as effect size and variance estimates, to guide successful conduct of a properly-powered clinical trial to assess the benefit of a mitochondrial cocktail…
- Conditions
- Gulf War Syndrome, Persian Gulf Syndrome, Mitochondrial Disorders
- Trial name
- NCT02804828
- Testing
- Individualized mitochondrial cocktail
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Diego
Gulf War Illness, Persian Gulf Syndrome
Exercise in Gulf War Illness (GWI)
The purpose of this study is to determine if submaximal exercise by bicycle stress tests with pulmonary measurement of VO2MAX plus maximal isometric hand grips on 2 consecutive days causes a higher level of "exertional…
- Trial name
- NCT01291758
- Testing
- Submaximal bicycle exercise stress tests performed 24 hr apart
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Persian Gulf Syndrome
Acupuncture in the Treatment of Gulf War Illness
This unblinded Phase II clinical trial tested the effects of individualized acupuncture treatments offered in extant acupuncture practices in the community; practitioners had at least 5 years of experience plus additional…
- Trial name
- NCT01305811
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- New England School of Acupuncture