Clinical trials: Gulf War Illness
Chronic Inflammation, Chronic Pain
Gulf War Illness Inflammation Reduction Trial
The primary objective of this clinical trial is to determine if treatment with an anti-inflammatory drug (delayed-release prednisone) improves the health-related quality of life (HRQOL) of veterans with Gulf War Illness (GWI).
- Conditions
- Chronic Inflammation, Chronic Pain, Fatigue, Cognitive Impairment
- Trial name
- GWIIRT (NCT02506192)
- Testing
- Modified-Release Prednisone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Persian Gulf Syndrome, Mycoplasma Infections
Antibiotic Treatment of Gulf War Veterans' Illnesses
In 1990 and 1991, the U.S. deployed approximately 700,000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. While there were few casualties associated with the Gulf War, many individuals returned from this…
- Trial name
- NCT00007735
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gulf War Illness
"Immunomodulation in GWI (Phlebotomy)"
Gulf War Illness and deployed veterans of the 1990-1991 Persian Gulf War are invited to have a brief history and physical examination to determine their health status, complete questionnaires, then donate about 83 ml of blood.
- Trial name
- NCT04058275
- Testing
- Draw blood (phlebotomy, 83 ml)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Gulf War Illness
Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI
This project's objective is to identify effective treatments for Gulf War Illness (GWI). The project tests three potential treatments: curcumin, stinging nettle, and resveratrol.
- Trial name
- NCT05377242
- Testing
- Curcumin, Resveratrol, Stinging Nettle
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Alabama at Birmingham
Gulf War Illness
Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness
Gulf War Illness (GWI) is a multi-symptom disorder that is characterized by complex traits such as fatigue, headaches, joint pain, insomnia, and memory problems.
- Trial name
- NCT02915237
- Testing
- Concord grape juice
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gulf War Illness, Irritable Bowel Syndrome
Mechanisms of Gulf War Illness
Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but…
- Conditions
- Gulf War Illness, Irritable Bowel Syndrome, Gastrointestinal Symptoms
- Trial name
- NCT05972291
- Testing
- Oral Glutamine, Control Arm
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness
TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset
Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances…
- Trial name
- E/M (NCT04254627)
- Testing
- Etanercept, Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Nova Southeastern University
Chronic Multisymptom Illness in Gulf War Veterans
A Controlled Trial of Mifepristone in Gulf War Veterans With Chronic Multisymptom Illness
We propose to conduct placebo-controlled trial of the glucocorticoid receptor antagonist mifepristone in Gulf War veterans (GWV) with chronic multisymptom illness (CMI) to examine its effects on physical and mental health and…
- Trial name
- NCT00691067
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Gulf War Syndrome, Chronic Fatigue Syndrome
Hyporeactivity and Gulf War Illness
This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation.
- Conditions
- Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
- Trial name
- NCT00100412
- Testing
- Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Apnea, Sleep, Chronic Fatigue Syndrome
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
The purpose of this study is to determine any sleep disordered breathing in veterans with Gulf War Syndrome (GWS) and compare it to healthy normal asymptomatic Gulf War veterans.
- Trial name
- NCT00252629
- Testing
- Nasal CPAP treatment during sleep
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- US Department of Veterans Affairs
Chronic Pain
rTMS for the Treatment of Chronic Pain in GW1 Veterans
This study was designed to evaluate the effect of repetitive Transcranial Magnetic Stimulation (rTMS) in the resolution of Chronic Pain.
- Trial name
- rTMS (NCT01608321)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Gulf War Syndrome
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum…
- Trial name
- NAC (NCT04987775)
- Testing
- N-Acetyl Cysteine
- Where
- 7 sites in United States
- Volunteers
- 170 people
- Sponsor
- Nova Southeastern University
Gulf War Illness
Probiotic (Visbiome) for Gulf War Illness
The overall objective is to determine whether Visbiome will improve 1. intestinal symptoms of Irritable Bowel Syndrome (IBS) and 2.
- Trial name
- NCT03078530
- Testing
- Visbiome, VSL#3
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ashok Tuteja
Irritable Bowel Syndrome
Effect of Diet on Gulf War Illness
Fermentable Oligo-, Di and Mono-saccharides And Polyols (FODMAPs) are carbohydrates that are poorly digested in intestines. The undigested carbohydrates are fermented in the colon by gut bacteria.
- Trial name
- NCT02881944
- Testing
- Low FODMAP Diet, High FODMAP Diet
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ashok Tuteja
Gulf War Illness
Collaborative Specialty Care for Gulf War Illness
Gulf War Veterans (GWVs) with Gulf War Illness (GWI) do not receive the care they should in the Veterans Affairs (VA). The investigators' data show 70% of GWVs with Gulf War Illness (GWI) do not receive treatment recommendations…
- Trial name
- NCT04403295
- Testing
- Collaborative Specialty Care, e-consultation
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- VA Office of Research and Development
Gulf War Syndrome, Adult Growth Hormone Deficiency
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)
The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD).
- Trial name
- GWIT (NCT05355272)
- Testing
- Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Gulf War Veterans Illness, Neurobehavioral Manifestations
Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
The purpose of this study is to learn if an experimental treatment can help thinking ability, and memory in Veterans with Gulf War Veterans Illnesses (GWVI).
- Conditions
- Gulf War Veterans Illness, Neurobehavioral Manifestations, Memory Disorders
- Trial name
- NCT01782378
- Testing
- Real LED Treatment
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Chronic Fatigue Syndrome, Fibromyalgia
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
The purpose of this study is: 1. To identify specific set of proteins in the cerebrospinal fluid (fluid surrounding the brain and the spinal cord), that are believed to be seen in Chronic fatigue syndrome (CFS) patients, but not…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Gulf War Illness, Multiple Chemical Sensitivity
- Trial name
- NCT00810329
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Chronic Multisymptom Illness in Gulf War Veterans
Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness
Following their deployment to the 1991 Gulf War, many veterans (GWV) reported a constellation of unexplained health symptoms; common among them were attention and memory difficulties, fatigue, joint pain, headaches…
- Trial name
- NCT01802944
- Testing
- Intranasal Insulin
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc