Clinical trials: Gut
Irritable Bowel Syndrome
Structured Patient Education Versus Written Information for Patients With Irritable Bowel Syndrome
In this randomized controlled study in patients with irritable bowel syndrome (IBS) we plan to compare the effects of a structured patient group education (IBS school) with receiving only written information in the form of a…
- Trial name
- NCT00706758
- Testing
- IBS school, IBS-guidebook
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Sahlgrenska University Hospital
Dietary Quality, Feasibility Studies
Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality in College Students: A Pilot Study
The goal of this single-arm feasibility, pilot study is to assess the feasibility, acceptability, and potential effectiveness of the Herbs and Spices Nutrition Education Program (HSNP-focusing on incorporating herbs and spices…
- Conditions
- Dietary Quality, Feasibility Studies, College Student, Dietary Guidelines for Americans
- Trial name
- HerbSpicesDiet (NCT07082348)
- Testing
- Herbs and Spices Nutrition Education Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nevada, Las Vegas
Colorectal Cancer
Capiri-sutent Phase-1 in Advanced Colo-rectal Cancer
The primary objective of this Phase 1 study is to identify the recommended dose of capiri and of sunitinib for combination therapy subsequent phase II trials.
- Trial name
- sutent-capiri (NCT00777478)
- Testing
- capiri-sutent
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Radboud University Medical Center
Ulcerative Colitis, Inflammatory Bowel Diseases
Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
FRESCO is a randomized, longitudinal, prospective, three arm, multicentre, double blind study to determine safety and efficacy of repeated faecal microbiota transplantation (FMT) or faecal microbiota filtrate transplantation…
- Trial name
- FRESCO (NCT03843385)
- Testing
- encapsulated faecal microbiota filtrate, encapsulated faecal microbiota
- Where
- 20 sites in Germany
- Volunteers
- 84 people
- Sponsor
- Andreas Stallmach
Roux-en-Y Bariatric Surgery
Investigation of the Effects of Obesity Surgery on Appetitive Behaviour
Among all the existing ways to treat obesity (lifestyle, pharmacological), Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective.
- Trial name
- NCT02010385
- Testing
- Octreotide, Saline
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Irritable Bowel Syndrome
Pilot Study Using a Dietary Intervention for Children With Irritable Bowel Syndrome
Malabsorption of certain foods (e.g. lactose) has been proposed as a cause of irritable bowel syndrome in adults and children. Recently, a diet that lowers intake of a combination of foods has been found to be effective in adults…
- Trial name
- NCT01018498
- Testing
- Restricted FODMAPs diet
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Irritable Bowel Syndrome Characterized by Constipation
Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C)
This study in patients with IBS-C is a randomized, double-blind, placebo-controlled, parallel-group clinical trial with 12 weeks of study drug therapy.
- Trial name
- IBS-C (NCT02493452)
- Testing
- Plecanatide
- Where
- 191 sites in United States
- Volunteers
- 1,135 people
- Sponsor
- Bausch Health Americas, Inc.
Gynecologic Cancer, Gynecologic Neoplasms
Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis
Background: Tumors that have spread to the lining of the abdomen from other cancers, such as cancer of the appendix, colon, or ovary, are called peritoneal carcinomatosis. In most cases, outcomes are poor.
- Conditions
- Gynecologic Cancer, Gynecologic Neoplasms, Peritoneal Carcinomatosis, Peritoneal Neoplasms
- Trial name
- NCT05185947
- Testing
- Paclitaxel, Nilotinib, ECG
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Non-celiac Gluten Sensitivity
Gluten and (Extra-)Intestinal Symptoms in NCGS
The goal of this randomized, double-blind, placebo-controlled study is to investigate the effect of expectancy related to gluten consumption versus actual gluten intake on overall GI symptoms in individuals with non-coeliac…
- Trial name
- WoW (NCT05779358)
- Testing
- Expectancy and gluten
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 84 people
- Sponsor
- Maastricht University
Fecal Calprotectin in Intestinal Protozoa
Fecal Calprotectin in Patients Infected with Intestinal Protozoan Infections
Calprotectin extracted from stool can be detected easily using ELISA. Numerous studies have shown that fecal calprotectin concentrations demonstrate a good correlation with intestinal inflammation This study aims to detect the…
- Trial name
- NCT06890455
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Colorectal Cancer
Selecting Treatment in Colorectal Cancer:Capecitabine or 5-fluorouracil Selection to be Combined With Oxaliplatin or Irinotecan as First-line Chemotherapy in Advanced Colorectal Cancer
The purpose of the study is to evaluate the efficacy and safety of the capecitabine or 5-fluorouracil selection, according to polymorphisms in TS-3'UTR and ERCC1-118, to be combined with oxaliplatin or irinotecan as first-line…
- Trial name
- SETICC (NCT01071655)
- Testing
- BVZ+XELOX or BVZ+XELIRI or BVZ+FUIRI or BVZ+FUOX, BVZ+XELOX
- Where
- Spain
- Volunteers
- 195 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Bladder Cancer, Breast Cancer
LMB-9 Immunotoxin in Treating Patients With Advanced Solid Tumors
RATIONALE: The LMB-9 immunotoxin may be able to locate tumor cells and kill them without harming normal cells. This may be an effective treatment for advanced solid tumors.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Esophageal Cancer
- Trial name
- NCT00019435
- Testing
- LMB-9 immunotoxin
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Hysterectomy
Total Versus Subtotal Hysterectomy:a Randomised, Prospective Multicentre Study of the Effect on Urinary, Sexual and Bowel Function
Background It is uncertain whether subtotal abdominal hysterectomy results in better bladder, bowel, or sexual function than total abdominal hysterectomy.
- Trial name
- NCT00750035
- Testing
- Total abdominal hysterectomy, Subtotal abdominal hysterectomy
- Where
- United Kingdom
- Volunteers
- 279 people
- Sponsor
- St George's Healthcare NHS Trust
Crohn's Disease
Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease
To evaluate the long-term maintenance of response, safety and tolerability of repeated administration of adalimumab in subjects with Crohn's disease who participated in and successfully completed Protocol M02-404 or Protocol…
- Trial name
- NCT00195715
- Testing
- Adalimumab
- Where
- 111 sites in United States, Australia and 13 more
- Volunteers
- 777 people
- Sponsor
- Abbott
Melanoma, Non Small Cell Lung Cancer
Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors
AI-061 is a co-formulation drug product (DP) consisting of 1:1 ratio mix of AI-025, an anti-PD-1 antibody, and ONC-392, an anti-CTLA-4 antibody.
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, High Grade Serous Adenocarcinoma of Ovary
- Trial name
- PRESERVE-009 (NCT05858736)
- Testing
- AI-061
- Where
- 5 sites in Australia
- Volunteers
- 18 people
- Sponsor
- OncoC4, Inc.
Crohn's Disease, Ulcerative Colitis
Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02862132
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Denmark and 4 more
- Volunteers
- 142 people
- Sponsor
- Shaare Zedek Medical Center
Colorectal Cancer, Breast Cancer
Promoting Cancer Screening Among Medicaid Recipients in Minnesota
This study evaluates the effectiveness of persuasive direct mail materials coupled with an incentive for increasing breast and colorectal cancer screening among people enrolled in Medicaid.
- Trial name
- NCT03275987
- Testing
- Mammography direct mail coupled with a financial incentive, Usual care, Colonoscopy direct mail coupled with a financial incentive
- Where
- United States
- Volunteers
- 138,554 people
- Sponsor
- Minnesota Department of Health
Colorectal Neoplasms
Study of Narrow Band Imaging in the Characterization of Residual Neoplasia After Endoscopic Piecemeal Mucosal Resection
This study is designed to evaluate the diagnostic accuracy of Narrow Band Imaging (NBI) compared with High Definition White Light colonoscopy (WLE) for detection of residual neoplasia in subjects with piecemeal polypectomy scars.
- Trial name
- CROMOPIE (NCT02448693)
- Testing
- WLE, NBI
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Parc de Salut Mar
Irritable Bowel Syndrome With Constipation
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
The objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (DR; DR formulation 1 is DR1; DR formulation 2 is DR2) administered orally to patients with…
- Trial name
- NCT02559206
- Testing
- Linaclotide
- Where
- 71 sites in United States
- Volunteers
- 759 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Stress Ulcer
Optimizing Stress Ulcer Prophylaxis Practices and Reducing Associated Costs in Intensive Care Units: a Nonrandomized Controlled Study
The study is a prospectively designed, nonrandomized controlled study. It was conducted for six months at the EICU and GICU of a training and research hospital between 1 Jun 2023 and 1 December 2023.
- Trial name
- NCT06586333
- Testing
- stress ulcer prophylaxis
- Where
- Turkey (Türkiye)
- Volunteers
- 196 people
- Sponsor
- Altinbas University
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