Clinical trials: Gut
Children With Allergic Rhinitis
Effectiveness of Probiotics in Relieving Allergic Rhinitis in Children
To evaluate the clinical efficacy of probiotic gummies in the trial of allergic rhinitis in children compared to placebo, as well as the modulating effect on gut microbiota, serum metabolic profile, and occurrence of adverse…
- Trial name
- NCT06676111
- Testing
- Probiotic
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Wecare Probiotics Co., Ltd.
Obesity, Metabolic Syndrome
Milk Types and Fish Oil in 9- to 12-Month-Old Infants
The objective of this intervention study is to examine the effect of whole cow's milk versus infant formula as primary milk sources with or without supplements of n-3 LCPUFA for growth, nutritional status, development, risk…
- Conditions
- Obesity, Metabolic Syndrome, Growth, Blood Pressure
- Trial name
- NCT00379171
- Testing
- Cow's milk with fish oil, Cow's milk without fish oil, Formula with fish oil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Patient Satisfaction and Efficacy of Bowel-preparation, Colon Cancer Prevention
Effectiveness of Nurse Tele-consultation on the Quality of Elective Colonoscopy, Procedure-related Anxiety, and Financial Toxicity
This is a multicenter, non-pharmacological, experimental, prospective, randomized study, with two arms (1:1) in a single-blind design.
- Trial name
- NCT06887244
- Testing
- Tele-consultation
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- National Cancer Institute, Naples
Colonoscopy
HalfLytely Bowel Prep System for Colonoscopy
The purpose of the this study was to compare the safety and efficacy of HalfLytely (2L NULYTELY + 20mg bisacodyl) to NULYTELY for preparation prior to colonoscopy.
- Trial name
- NCT00164164
- Testing
- HalfLytely, NuLytely
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Braintree Laboratories
Mucinous Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer
Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery
This randomized pilot clinical trial studies the side effects of giving paricalcitol together with fluorouracil and radiation therapy in treating patients with rectal cancer that can be removed in surgery.
- Conditions
- Mucinous Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer, Stage IIB Rectal Cancer, Stage IIC Rectal Cancer
- Trial name
- NCT01197664
- Testing
- paricalcitol, radiation therapy, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Rectal Cancer
Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer
Background Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatments for patients with locally advanced rectal cancer.
- Trial name
- ARF-RC (NCT05671809)
- Testing
- NCRT with surgery, or NCT with surgery, or surgery
- Volunteers
- 402 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Healthy
Where is the Initial Site of Biotransformation of Folates in Humans?
The aim of this study is to test the assumption that, in humans, folic acid, a dietary supplement is biotransformed (reduced and methylated) to the natural circulating plasma folate 6S-5Methyltetrahydrofolic acid (5-MTHF) in the…
- Trial name
- FOLTIPS (NCT02135393)
- Testing
- 13C5-folic acid or 13C5-6S-5-FormylTHF
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Cryptogenic Pyogenic Liver Abscess
Prevalence of Colon Cancer in Pyogenic Liver Abscess
Although a proportion of pyogenic liver abscess may originated from colonic mucosal lesions, the prevalence of colonic neoplasm in the patients with pyogenic liver abscess are still not evaluated yet.
- Trial name
- NCT02032914
- Where
- 2 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Inje University
Crohn's Disease
Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis
Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract. The origin of Crohn's disease remains unknown and there is no curative therapy, either medical or surgical, for this gut disorder.
- Trial name
- NCT00513552
- Testing
- Rifabutin, Clarithromycin, and Clofazimine
- Sponsor
- Medstar Health Research Institute
Colo-rectal Cancer, Colon Cancer
Ellagic Acid, Urolithin and Colonic Microbial Communities Affected by Walnut Consumption
Briefly, this is a 28-day dietary intervention study participants will be asked to eat 2 ounces (52 grams) of walnuts every day for 3 weeks, and at the end of the study period they will come in for a colonoscopy.
- Conditions
- Colo-rectal Cancer, Colon Cancer, Diet Habit
- Trial name
- NCT04066816
- Testing
- Walnuts
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- UConn Health
Metastatic Colorectal Cancer
Safety, Tolerability and Pharmacokinetics of Oral Tablet of Irinotecan in Adult Patients With Solid Tumors
This study evaluates the safety, tolerability and pharmacokinetics of oral administration of irinotecan in adult patients. Oral irinotecan will be administered as monotherapy in a dose escalation trial to establish the Maximal…
- Trial name
- NCT03295084
- Testing
- Irinotecan, Capecitabine
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Dorte Nielsen
Diarrhea- Predominant Irritable Bowel Syndrome, Quality of Life
Effects of Mesalamine and Amitriptyline on Irritable Bowel Syndrome
The aim of this study is to evaluate the effects of Mesalamine and Amitriptyline drugs on the Quality of Life and Symptom Severity Scale in patients with Diarrhea- Predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- NCT02190526
- Testing
- Mesalazine(asacol 800 mg), Amitriptyline
- Where
- Iran
- Sponsor
- Tehran University of Medical Sciences
Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
EL CENTRO: Engaging Latinos in the Center of Cancer Treatment Options
The objective of this study is to improve the chemotherapy decision making process for Latinos with advanced gastrointestinal cancers.
- Conditions
- Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT03602885
- Testing
- Usual chemotherapy education (CE), Chemotherapy education intervention (CEI)
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer of Pancreas, Cancer of Duodenum
Enteral Nutrition After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the treatment of choice for resectable periampullary cancer. PD is still associated with a relatively a high incidence of delayed gastric emptying.
- Conditions
- Cancer of Pancreas, Cancer of Duodenum, Ampulla of Vater Cancer, Cholangiocarcinoma
- Trial name
- NCT03150615
- Testing
- Early enteral nutrition, Saline, nasojejunal tube insertion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
IBS - Irritable Bowel Syndrome
Efficacy and Safety of a Probiotic Formulation in Adults With Irritable Bowel Syndrome With Diarrhea (IBS-D)
The purpose of the study is to monitor safety and to evaluate the efficacy of a probiotic formulation on abdominal pain, abnormal defecation, comorbid mood disorders (anxiety and depression) as well as general quality of life in…
- Trial name
- NCT05509725
- Testing
- Probiotic formulation
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
Gastric Ulcer, Duodenal Ulcer
Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer
The purpose of this study is to assess the Safety and tolerability of D961H (Esomeprazole) 20 mg once daily for up to 52 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- NCT00595517
- Testing
- Esomeprazole 20 mg
- Where
- 3 sites in Japan
- Volunteers
- 395 people
- Sponsor
- AstraZeneca
Glucose Metabolism Disorders, Health Behavior
Relationship Between Individual Effect of Diet on Postprandial Glycemia and Gut Microbiome Profile in Healthy Subjects
When all the food we eat is digested, it will increase blood glucose. Two people can have different glucose blood levels to the same food and one reason can be bacteria live in our gut.
- Conditions
- Glucose Metabolism Disorders, Health Behavior, Diabetes, Metabolic Disease
- Trial name
- NCT06051318
- Testing
- Standardized breakfast A, Standardized breakfast B
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- BiomeHub Biotechnology Company
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using AI System in China
The primary aim of this study is to explore the usefulness of Artificial Intelligence system in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Artificial Intelligence is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoAIADR (NCT03840590)
- Testing
- CSK AI system, Standard Colonoscopy
- Where
- 4 sites in China
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer
Neoadjuvant Triplet Chemotherapy Regimen in Patients With Resectable Colorectal Cancer
Colorectal cancer is an aggressive malignancy with a poor overall outcome. The purpose of this study is to evaluate the feasibility, safety and efficacy of neoadjuvant oxaliplatin, irinotecan combined with…
- Trial name
- NCT02688023
- Testing
- oxaliplatin;irinotecan;leucovorin;5-fluorouracil;capecitabine;S-1
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese Academy of Medical Sciences
Rectal Cancer
Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX Chemotherapy for Rectal Cancer
Standard treatment for rectum cancer is a pre-surgery course of external beam radiotherapy given with chemotherapy at the same time.
- Trial name
- HDRBT (NCT01659424)
- Testing
- High Dose Rate Endorectal Brachytherapy (HDR-ERBT)
- Where
- 2 sites in United States
- Sponsor
- Beth Israel Medical Center
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