Clinical trials: Gut
Colorectal Neoplasms, Colonic Neoplasms
Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer.
To compare treatment with oxaliplatin/5-FU/leucovorin plus vatalanib versus oxaliplatin/5-FU/leucovorin plus placebo in patients with colorectal cancer that has spread to other organs and are seeking first chemotherapy treatment
- Conditions
- Colorectal Neoplasms, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- NCT00056459
- Testing
- Vatalanib
- Where
- 223 sites in United States, Australia and 17 more
- Volunteers
- 1,168 people
- Sponsor
- Novartis
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Irritable Bowel Syndrome
Study of Fecal Microbiota Transplantation (FMT) in Severe IBS Patients
The objective of this protocol is to evaluate the efficacy of fecal microbiota transplantation (FMT) using oral capsules containing frozen stools vs sham FMT on IBS severity score at 12 weeks in patients with severe irritable…
- Trial name
- ICEBOAT (NCT06433180)
- Testing
- Administration of fecal microbiota transplantation ( FMT capsules)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anal Cancer Patients
Patient Reported Outcomes (PROs) in Anal Cancer Patient Treated by Intensity Modulated Radiotherapy (IMRT).
Radiochemotherapy is the standard treatment for neoplasms of the anal canal with excellent rates of local control and preservation of the anal sphincter.
- Trial name
- PROACT (NCT06364579)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recurrent Colorectal Cancer
A Study of Radiotherapy Combined With Raltitrexed and Irinotecan in Metastatic or Locally Recurrent Colorectal Cancer
The study evaluates the effectiveness of radiotherapy combined with raltitrexed and irinotecan in treating patients who have metastatic or locally recurrent colorectal cancer that has not responded to fluorouracil.
- Trial name
- NCT04499586
- Testing
- Radiotherapy Combined With Raltitrexed and Irinotecan
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Ulcerative Colitis (UC), Fecal Calprotetin
DYNAMIC-UC: Early qFIT and Calprotectin Change Predicting Relapse in Biologic-Naive Ulcerative Colitis
This multicenter prospective cohort study aims to evaluate whether a >50% decrease or normalization of both quantitative fecal immunochemical test (qFIT) and fecal calprotectin (FC) levels at 2 weeks after starting conventional…
- Conditions
- Ulcerative Colitis (UC), Fecal Calprotetin, FIT, Biomarker
- Trial name
- DYNAMIC-UC (NCT07111273)
- Testing
- FC and FIT TEST at WEEK0 2 4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Colorectal Cancer Stage IV
AREG, EREG and EGFR: Response to Anti-EGFR Agents in Colorectal Cancer
Observational study investigating the relationship between tumour amphiregulin, epiregulin and epithelial growth factor receptor expression and response to anti-EGFR agents in advanced colorectal cancer.
- Trial name
- NCT03986541
- Testing
- Immunohistochemistry
- Where
- 7 sites in United Kingdom
- Volunteers
- 541 people
- Sponsor
- University of Leeds
Colon Cancer, Colon Disease
Analyzing Clinical Trial Experiences of Colon Cancer Patients
Participation in medical trials usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups.
- Trial name
- NCT05715905
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Crohn Disease
Stress in Crohn's Disease
There is little information on how Crohn's disease progresses in between a patient's clinic visits and how stress impacts symptom change including flare-ups.
- Trial name
- NCT04809194
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 195 people
- Sponsor
- 4YouandMe
Inflammatory Bowel Diseases
Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous as Induction Therapy in Patients With Active CD or UC
The goal of this clinical trial is to compare induction treatment with CT-P13 SC to induction treatment with CT-P13 IV in terms of pharmacokinetics in adult patients with inflammatory bowel disease (IBD) who have been diagnosed…
- Trial name
- PASSPORT (NCT06274294)
- Testing
- CT-P13
- Where
- France
- Volunteers
- 130 people
- Sponsor
- CMC Ambroise Paré
Low Anterior Resection Syndrome
Transanal Irrigation for Low Anterior Resection Syndrome.
The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low…
- Trial name
- HiLoV_TAI (NCT05245331)
- Testing
- Peristeen® Transanal irrigation system with the conic catheter, Standard reusable enema
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Colon Cancer, Immunotherapy
Tirellizumab+Anlotinib VS Anlotinib for MSS-type CRC
To compare the efficacy and safety of tirellizumab combined with anlotinib in the treatment of mss colorectal cancer. To investigate the effective biomarker of anlotinib combined with tiralizumab
- Trial name
- NCT06573424
- Testing
- Tislelizumab+anlotinib, anlotinib
- Where
- China
- Volunteers
- 124 people
- Sponsor
- fan li
Ulcerative Colitis
Generate Real World Data On Tofacitinib Induction Therapy and Changes In Clinical and Patient Reported Outcomes.
This study is expected to contribute to the body of real-world data of tofacitinib's safety and efficacy profile in ulcerative colitis.
- Trial name
- KIC-START (NCT05069259)
- Testing
- Stool sample collection
- Where
- 5 sites in Switzerland
- Volunteers
- 18 people
- Sponsor
- Pfizer
Covid19, Appendicitis
the Impact of COVID-19 Pandemic on the Incidence and Outcome of Complicated Appendicitis
During the COVID-19 pandemic, we noticed a rise in complicated appendicitis cases presenting to our medical center. We collected objective data on all patients admitted to the surgical department with appendicitis during February…
- Trial name
- NCT04786041
- Testing
- laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Colon Cancer
Using Probiotics to Reactivate Tumor Suppressor Genes in Colon Cancer
The purpose of the study is to determine if probiotic bacteria have a beneficial effect on the colon cancer-associated microbiota and epigenetic alterations in colon cancer.
- Trial name
- NCT03072641
- Testing
- ProBion Clinica
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer, Colorectal Cancer
The Engaging Primary Care in Cancer Survivorship (EPICS) Study
A quasi-experimental non-randomized pre/post with control group trial of two models of cancer survivorship care in early-stage colorectal and breast cancer survivors cared for in a community-based, integrated health care setting.
- Trial name
- EPICS (NCT04745754)
- Testing
- Embedded primary care in cancer survivorship model
- Where
- 13 sites in United States
- Volunteers
- 2,450 people
- Sponsor
- Kaiser Permanente
Advanced Solid Tumors
Phase I Study of OSI-930 and Erlotinib in Cancer Tumors
This is a Phase I, dose escalation, safety study of OSI-930 and Erlotinib in cancer tumors.
- Trial name
- NCT00603356
- Testing
- OSI-930 and erlotinib
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Astellas Pharma Inc
Ulcerative Colitis, Crohn's Disease
A Phase I Study of Etrolizumab Followed by Open-Label Extension and Safety Monitoring in Pediatric Patients With Moderate to Severe Ulcerative Colitis or Moderate to Severe Crohn's Disease
This study will evaluate pharmacokinetics, pharmacodynamics and safety of etrolizumab in pediatric patients of 4 to <18 years of age with moderate to severe ulcerative colitis (UC) or with moderate to severe Crohn's disease (CD).
- Trial name
- FENNEL (NCT03478956)
- Testing
- Etrolizumab
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of romidepsin and lenalidomide when combined with rituximab and to see how well this combination works in treating patients with B-cell non-Hodgkin lymphoma that has…
- Conditions
- B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Intraocular Lymphoma, Nodal Marginal Zone B-cell Lymphoma
- Trial name
- NCT02281279
- Testing
- rituximab, lenalidomide, romidepsin
- Sponsor
- Mayo Clinic
Ulcerative Colitis
Phase 2a Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Ulcerative Colitis
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Symptomatic Ulcerative Colitis Patients with Moderate to…
- Trial name
- TOP2 (NCT02888379)
- Testing
- TOP1288
- Where
- 28 sites in Bulgaria, Czechia and 6 more
- Volunteers
- 77 people
- Sponsor
- Topivert Pharma Ltd
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