Clinical trials: Gut
Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung
Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases
This phase II trial studies how well chemotherapy and/or metastasectomy work in treating patients with colorectal adenocarcinoma that has spread to the lungs (metastases).
- Conditions
- Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8
- Trial name
- NCT03599752
- Testing
- Chemotherapy, Metastasectomy
- Where
- 6 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Adenoma, Colorectal Cancer
Early Screening of Colorectal Cancer Based on Plasma Multi-omics Combining With Artificial Intelligence
To evaluate the accuracy and effectiveness of a novel screening method based on plasma multi-omics combining with artificial intelligence in a large prospective cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- RECOMMEND (NCT05587452)
- Testing
- Colonoscopy, Test of ctDNA methylation, Test of characteristics of ctDNA fragment
- Where
- 5 sites in China
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer
ReAL Trial (Rectal Anastomotic seaL)
The problem of anastomotic leak is particularly relevant in rectal surgery. Many risk factors have been recognized in the onset of this complication.
- Trial name
- ReAL (NCT03941938)
- Testing
- Cyanoacrylate reinforcement, No reinforcement
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Crohn's Disease, Ulcerative Colitis
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease
Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Healthy Controls
- Trial name
- NCT03397108
- Testing
- The IBD group was divided into 2 subgroups: with or without anti-TNF antibody use
- Where
- 2 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Lung Disease, Brain Injury
Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology
This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC)…
- Conditions
- Lung Disease, Brain Injury, Necrotizing Enterocolitis, Respiratory Failure
- Trial name
- NCT00315263
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Children's Mercy Hospital Kansas City
Nutrition, Healthy
Effect of L. Plantarum Probiotic Supplementation on Broccoli Sulforaphane Bioavailability: Randomised Double-blind Placebo-controlled Crossover Study
Broccoli has the precursor of an active compound (sulforaphane) that has shown a wide range of health promoting benefits. Sulforaphane formation depends on the conversion of glucoraphanin (precursor) by myrosinase enzyme.
- Trial name
- PRO-BROC (NCT06561893)
- Testing
- Broccoli sprouts extract supplementation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
IBD (Inflammatory Bowel Disease)
The Clinical Efficacy and Influence Factors of Individualized Treatment of Ustekinumab in Crohn's Disease
The loss of response rate of ustekinumab(UST) is high, and the specific mechanism has not yet been elucidated. Our study aimed to retrospectively analyze the clinical efficacy and influence factors of individualized treatment of…
- Trial name
- NCT06785493
- Testing
- Optimized Treatment (OPT)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pancreatic Ductal Adenocarcinoma, Colorectal Cancer
FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; A Dose Escalation Study for TReatment of Patients With Select Solid Tumors (FRONTIER)
This Phase 1 study will evaluate the safety and tolerability of [Ga-68]-PNT6555 and [Lu-177]-PNT6555 in subjects with select solid tumors that have FAP over-expression, in order to determine a recommended Phase 2 dose.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Esophageal Cancer, Melanoma (Skin)
- Trial name
- NCT05432193
- Testing
- [Ga-68]-PNT6555, [Lu-177]-PNT6555
- Where
- 4 sites in United States, Canada
- Volunteers
- 20 people
- Sponsor
- POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Ulcerative Colitis
Study of the Golimumab Exposure-Response Relationship Using Serum Trough Levels
The purpose of this study is to gain insight into the exposure-response relationship of golimumab in moderate-to-severe Ulcerative Colitis (UC).
- Trial name
- GO-LEVEL (NCT03124121)
- Testing
- Golimumab
- Where
- United Kingdom
- Volunteers
- 112 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
CKD, PAD
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD
Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD).
- Trial name
- NCT04788914
- Testing
- Active bamboo charcoal± probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
IBS
Effects of Mexiletine on Colonic Transit in a Patient With Irritable Bowel Syndrome - Constipation (IBS-C)
To understand if Mexiletine will restores normal colonic motility in a patient with irritable bowel syndrome - constipation (IBS-C) and a genetic mutation in SCN5A.
- Trial name
- NCT01717404
- Testing
- Mexiletine
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Lung Tumor
Gut Microbiota And Radiotherapy
A pilot, single arm, single center study to determine the feasibility of obtaining stool samples from adult patients receiving SBRT to a lung tumor, if SBRT induces changes in the gut microbiota and to obtain preliminary data…
- Trial name
- NCT02559349
- Testing
- Stool Collection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Endothelial Dysfunction, High Blood Pressure
Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome
Previous research has revealed that adults with pre-hypertensive and hypertensive blood pressure levels typically exhibit impaired vasodilation, which is a crucial aspect of blood vessel function, due to decreased nitric oxide…
- Conditions
- Endothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and Nutrition
- Trial name
- NCT06502535
- Testing
- Inulin, Potassium nitrate and inulin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Exeter
Artificial Intelligence, Colonic Polyp
Intelligent-C Endoscopy Module for Real-time Detection of Colonic Lesions
To conduct an single blinded, non-randomized, prospective, single center trial to validate the performance of a novel state-of-the-art Artificial Intelligence model (AI-Model) for colorectal lesion detection during routine…
- Trial name
- iIDEAS/RTD (NCT05784935)
- Testing
- Real time AI detection model
- Where
- India
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Colorectal Cancer
Participation and Detection Rate of Screening CT Colonography and Screening Sigmoidoscopy
The objectives of this multicenter, randomized trial is to assess the participation rate achievable through two different screening strategies (Computed Tomographic Colonography-CTC and sigmoidoscopy-FS), to compare detection…
- Trial name
- Proteus (NCT01739608)
- Testing
- Invitation to screening
- Where
- Italy
- Volunteers
- 40,945 people
- Sponsor
- Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte
High Risk Polyposis Syndrome, Distal Colonic Lesions
Indocyanine Green Fluorescent Molecular Imaging of the Gastrointestinal Tract
Standard white light endoscopy involves the passage of a thin, flexible camera into the colon from the anus. Although standard white light endoscopy can detect most polyps and precancerous areas in the gastrointestinal tract and…
- Conditions
- High Risk Polyposis Syndrome, Distal Colonic Lesions, Colorectal Polyps
- Trial name
- NCT01112514
- Testing
- indocyanine green
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Massachusetts General Hospital
Metastatic Colorectal Cancer
FLOX in Combination With Cetuximab in First-line Treatment of Colorectal Cancer
The main objective of this trial is to explore the effect of combining an established chemotherapy regimen (FLOX), based on 5-fluorouracil, folinic acid, and oxaliplatin (Eloxatin®), with the EGF receptor antibody cetuximab…
- Trial name
- NCT00145314
- Testing
- FLOX (5-fluorouracil/folinic acid/oxaliplatin), FLOX (5-fluorouracil/folinic acid/oxaliplatin) and Cetuximab, FLOX (5-fluorouracil and folinic acid and oxaliplatin) intermittently and maintenance cetuximab
- Where
- Norway
- Volunteers
- 571 people
- Sponsor
- The Nordic Colorectal Cancer Biomodulation Group
Adhd, ALS
National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function.
The objective of the study will be to understand whether a supplementation of the diet with an active symbiotic, i.e. characterized by a mix of probiotics and a specially selected fiber with prebiotic activity combined with a…
- Conditions
- Adhd, ALS, Bronchial Asthma
- Trial name
- sPATIALS3 (NCT06005506)
- Testing
- Prebiotic fiber, Dietary fiber, Probiotic
- Where
- 4 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Institute of Biomedical Technologies-National Research Council, Italy
Advanced or Metastatic Solid Tumors
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations
To evaluate the efficacy of naporafenib administered with trametinib in patients with rat sarcoma viral oncogene (RAS) Q61X solid tumors To evaluate the safety and tolerability of naporafenib administered with trametinib in…
- Trial name
- SEACRAFT-1 (NCT05907304)
- Testing
- Naporafenib, Trametinib
- Where
- 29 sites in United States, Australia and 3 more
- Volunteers
- 86 people
- Sponsor
- Erasca, Inc.
GIST - Gastrointestinal Stromal Tumor, GIST
KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)
This study will test an experimental drug called KQB198 in combination with imatinib. The goal is to determine if this combination is safe and tolerable and assess how effective the combination is at treating GIST.
- Conditions
- GIST - Gastrointestinal Stromal Tumor, GIST, GIST Metastatic Cancer, Gastro Intestinal Stromal Tumour
- Trial name
- NCT07406633
- Testing
- KQB198, Imatinib (Gleevec)
- Where
- 17 sites in United States
- Volunteers
- 46 people
- Sponsor
- Kumquat Biosciences Inc.
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