Clinical trials: Gut
Colorectal Neoplasms
Study of Intrahepatic Arterial Infusion of TG6002 in Combination With 5-FC in Patients With Metastatic Colorectal Cancer
This study will include two parts: Phase I part is a dose-escalation study to assess the safety of increasing doses of TG6002 in combination with oral flucytosine (5-FC) in consecutive cohorts of 3 to 6 patients with colorectal…
- Trial name
- NCT04194034
- Testing
- TG6002, Flucytosine (5-FC)
- Where
- 3 sites in France, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Transgene
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases
FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis
FARGO is a randomised, phase IIa, multi-centre, placebo-controlled trial to compare Faecal Microbiota Transplant (FMT) with placebo in patients with primary sclerosing cholangitis (PSC) and concomitant inflammatory bowel disease.
- Trial name
- FARGO (NCT06286709)
- Testing
- Faecal Microbiota Transplant
- Where
- 5 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Birmingham
Colitis, Ulcerative, Crohn Disease
A Study to Evaluate Disease Control and Treatment Pattern in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD) in Real Life Practice
The purpose of this study is to characterize the treatment patterns associated with biologics agents use or non-biological therapy in participants with moderate to severe Ulcerative Colitis (UC) and Crohn's Disease (CD).
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- INTENT (NCT03532932)
- Where
- 36 sites in Belarus, Kazakhstan and 1 more
- Volunteers
- 1,990 people
- Sponsor
- Takeda
HIV, Hepatitis C, Chronic
The Study of Gut Associated Lymphocytes in HIV and HCV/HIV Co-infected Patients
The purpose of this research study is to explore what role immune cells within the gut (the sigmoid colon) have locally and on the immune system of patients infected with HCV, HIV or HCV/ HIV co-infection.
- Conditions
- HIV, Hepatitis C, Chronic, HCV Coinfection
- Trial name
- NCT01335230
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bowel Preparation for Colonoscopy
A Pilot Evaluation of an Experimental BLI4600 Formulation for Bowel Preparation in Adult Patients Undergoing Colonoscopy
To evaluate the safety, tolerance and efficacy of BLI4600 in multiple dosing regimens as a bowel preparation prior to colonoscopy in adult patients.
- Trial name
- NCT02376465
- Testing
- BLI4600 bowel preparation, PEG based bowel preparation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Braintree Laboratories
Colon Polyp
Combined Chromoendoscopy and Water Method for Screening Colonoscopy
In a RCT in screening colonoscopy subjects, we will determine if chromoendoscopy using a dilute solution of Indigocarmine (IC) delivered by the water method (study method) will improve adenoma detection rate compared with the…
- Trial name
- NCT01383265
- Testing
- Water method and chromoendoscopy, Water method
- Where
- United States
- Volunteers
- 1,177 people
- Sponsor
- VA Northern California Health Care System
Intestinal Pseudo-Obstruction, Fecal Microbiota Transplantation
Investigation of Fecal Microbiota Transplant in Chronic Intestinal Pseudo-obstruction Patients
Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare gastrointestinal disorder that primarily affects the movement of the intestines, leading to symptoms that resemble a true bowel obstruction but without a physical blockage.
- Trial name
- FMT-CIP (NCT06020365)
- Testing
- sequential fecal microbiota transplant combined with small intestinal fluid transplant
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai 10th People's Hospital
Intestinal Anastomosis
Early Enteral Feeding After Intestinal Anastomosis
The concept of starting the patient on early enteral nutrition has been a topic of much interest and research in the past decade.
- Trial name
- NCT00739271
- Testing
- Early feeding, late feeding after bowel sounds return
- Where
- India
- Volunteers
- 82 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Anal Fissure, Anal Fistula
Ultrasound Guided Caudal Block for Benign Anal Surgery
Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery
- Conditions
- Anal Fissure, Anal Fistula, Hemorrhoids, Pain, Postoperative
- Trial name
- NCT03345511
- Testing
- Ultrasound Guided Caudal Block
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Universidad de Antioquia
Insulin Resistance, Ethanol
The Effects of Ethanol on Intestinal Permeability and Gut Hormones
The aime of this study is to envsitigate if ethanol has an incretin effect. This is done by administration of ethanol orally vs. an isoethanolaemic i.v. infusion of ethanol.
- Conditions
- Insulin Resistance, Ethanol, Incretin Effect
- Trial name
- NCT03348371
- Testing
- Ethanol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Ulcerative Colitis
COLISURG : Exploratory Analysis of Sexual Function and the Impact of Biotherapies on Postoperative Morbidity.
The surgical treatment of the ulcerative colitis (UC) remains associate to a significant morbidity (up to 60%). Anastomotic fistula and pelvic sepsis are the most severe complications which could dramatically compromise the…
- Trial name
- COLISURG (NCT03504930)
- Testing
- Impact of biotherapy on postoperative morbidity in ulcerative colitis
- Where
- 22 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
AI Care Device
Artificial Intelligence-based Dietary Care System
Patients with rectal cancer complicated by low anterior resection syndrome who undergo anal-preserving surgery may experience severe distress in daily life due to changes in bowel function, thus requiring significant…
- Trial name
- AI DC-system (NCT07637565)
- Testing
- Artificial Intelligence-based Dietary Care System, Routine Care
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer, Peritoneal Metastasis
Histopathological Response to FOLFOXIRI + Bevacizumab in Peritoneal Metastasis From Colorectal Cancer
There is a paucity of data on the histopathological response of peritoneal tumor deposits from colorectal cancer to neoadjuvant chemotherapy.
- Trial name
- CARCINOSIS (NCT02591667)
- Testing
- Upfront staging laparoscopy + peritoneal biopsy, Neoadjuvant chemotherapy with FOLFOXIRI + bevacizumab, Surgical re-exploration
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Colorectal Cancer, Solid Tumor
Real-world Study to Evaluate the Efficacy and Safety of Liposome Irinotecan
This study is a prospective, multicenter, real-world study. There are four cohorts. Cohorts 1-3 include second-line, posterior-line, and neoadjuvant colorectal cancer patients, respectively.
- Trial name
- NCT06443307
- Testing
- Irinotecan Liposome
- Where
- China
- Volunteers
- 933 people
- Sponsor
- Peking University
Colorectal Cancer, Gastroesophageal Cancer
A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal Cancer
Background: People with colorectal cancer (CRC) or gastroesophageal cancer (GEC) must often have major surgery to remove tumors from the esophagus, stomach, colon, or rectum.
- Trial name
- NCT06410534
- Testing
- nivolumab, ipilimumab
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Colo-rectal Cancer
The United States Healthy Living Study
The purpose of this study is to pilot test the efficacy of a patient-centered, tailored message intervention delivered via virtual human technology for increasing colorectal cancer (CRC) screening within guidelines.
- Trial name
- NCT03867409
- Testing
- message delivered via virtual technology
- Where
- United States
- Volunteers
- 2,105 people, healthy volunteers welcome
- Sponsor
- University of Florida
Intestinal Bacteria Flora Disturbance
The Effect of Fruit/Vegetable Drinks on the Human Intestine
This is a 4 ½ week study with 20 healthy subjects (including a 2 week run-in ) . Subjects will be taking vegetable/fruit juice supplementation for 3 days.
- Trial name
- NCT02377063
- Testing
- Pressed Juice
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Polyp of Colon
Linked Color Imaging Versus White Light Endoscopy for the Evaluation of Scars of Non-pedunculated Polyps. LCI Scar Study.
Careful inspection and evaluation of the post-polipectomy scars of polyps greater than 20 mm looking for residual polyp is mandatory. LCI has demonstrated to improve polyp and adenoma detection rate in previous studies.
- Trial name
- LCIScar (NCT04899700)
- Testing
- Linked Color Imaging, White light endoscopy
- Where
- 2 sites in Spain
- Volunteers
- 173 people
- Sponsor
- Hospital Clinic of Barcelona
Ischemic Stricture of Intestine
Safety and Effectiveness Evaluation of the ISS System in Treatment of Acute Ischemic Stroke
The primary objective of this pilot study is the assessment of the safety of the ISS500 System in patients who have experienced an acute ischemic stroke within the anterior circulation.
- Trial name
- ImpACT-1 (NCT03733236)
- Testing
- ISS Active Stimulation
- Where
- 2 sites in India
- Volunteers
- 98 people
- Sponsor
- BrainsGate
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