Clinical trials: Gut Bacteria
Intestinal Bacteria Flora Disturbance
Multi-Antibiotic Resistance Carriage in Gut Flora
Prevalence Study evaluating the acquisition of carriage of multidrug-resistant Gram-negative bacteria (MDRGNB) in the gut flora in volunteers of French Armed Forces staying from 4 to 6 months outside France.
- Trial name
- MARC (NCT01591538)
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Intestinal Transit
Gut Transit Effect on Enterohepatic Circulation
A study to determine the influence of changing intestinal transit time of the enterohepatic recirculation of bile acids.
- Trial name
- NCT03501498
- Testing
- Loperamide, Senna
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Crohn's Disease, Dietary Modification
The Impact of "Crohn's Disease-TReatment-with-EATing" Diet and Exclusive Enteral Nutrition on Healthy Gut Bacteria
Current evidence suggests that the gut microbiota and dietary influences are as important as genetics in the aetiology of Crohn's disease (CD).
- Trial name
- NCT02426567
- Testing
- Exclusive Enteral Nutrition (EEN), Crohn's Disease TReatment-with-EATing diet (CD-TREAT diet)
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Healthy
The Effect of Grape Consumption on Increasing the Good Bacteria in the Human Intestine
This pilot study will assess the ability of daily consumption of one dose (2 servings) of freeze-dried whole table grape powder, made from conventionally grown grapes to alter the composition of the bacteria that live in the…
- Trial name
- NCT05025189
- Testing
- Table Grape Powder, Beige Diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Intestinal Bacteria Flora Disturbance, Constipation
Effects of Probiotic on Modulation of the Intestinal Microbiota in Constipated Patients
The probiotic for oral use, Probiatop®, consists of Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus HN001, Lactobacillus paracasei LPC-37 and Bifidobacterium lactis HN019.
- Trial name
- NCT03103958
- Testing
- Probiotic
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Farmoquimica S.A.
Irritable Bowel Syndrome (IBS)
The Role That Food and Bacteria Play in Generating Abdominal Pain
Irritable Bowel Syndrom (IBS) affects up to five percent of Canadians and has proven difficult to treat. Our research will explore how a type of dietary carbohydrate, called FODMAPS, contributes to chronic abdominal pain in…
- Trial name
- NCT07688044
- Testing
- FODMAP Challenge
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- David Reed
Microbial Colonization
Impact of Quinoa Milk Fermented With Lactic Acid Bacteria From Foods on Human Oral and Intestinal Flora
The demand for alternatives to dairy products has increased in recent years and a lot of proposals for vegetable milk and yogurt products have taken place in the market.
- Trial name
- NCT04280731
- Testing
- fermented quinoa
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity, High Blood Pressure
Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome
This study will investigate the effects of curcumin on the structure/function of the body by investigating whether targeted improvement of intestinal barrier function by supplementation with oral curcumin will result in…
- Conditions
- Obesity, High Blood Pressure, High Cholesterol, Type2 Diabetes
- Trial name
- NCT03542240
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Cardiovascular Disease, Constipation
Dose-Response Study of Probiotic Bacteria BB-12 and CRL-431 in Healthy Young Adults
The purpose of the study was to investigate the dose-response effect of increasing doses of Bifidobacterium animalis ssp lactis (BB-12) and Lactobacillus paracasei ssp paracasei (CRL-431) on the immune response, blood lipids, gut…
- Trial name
- NCT00611299
- Testing
- BB-12 and CRL 431
- Where
- Denmark
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Alcoholic Intoxication, Alcohol-Related Disorders
Longitudinal Changes in the Oral and Gut Microbiome of Individuals With Alcohol Dependence
Background: Many bacteria live in the gut. The gut is the tube that moves food from the mouth through the stomach to the intestines. Heavy alcohol use disturbs these bacteria.
- Trial name
- NCT02911077
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Ischemic Stroke, Atherosclerosis
The Gut and Oral Bacteria, Atherosclerosis and Ischemic Stroke Study
The main aim of this project is to demonstrate an association between gut and oral microbiota and their metabolites to carotid atherosclerosis and risk of ischemic stroke.
- Conditions
- Ischemic Stroke, Atherosclerosis, Microbiota
- Trial name
- NCT04803838
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria.
- Conditions
- Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection
- Trial name
- AB-care (NCT06919068)
- Testing
- Colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Obesity, Intestinal Bacteria Flora Disturbance
Study on Dietary Nutrition Intervention Techniques for Children Obesity
With the rapid development of society and economy, children's simple obesity is the rising in the world and has become a chronic disease which is one of the biggest public health challenges in the world.
- Conditions
- Obesity, Intestinal Bacteria Flora Disturbance, Body Weight
- Trial name
- NCT02539836
- Testing
- Dietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol
The aim of the study is to assess the safety and efficacy of new protocol fecal microbiota transplantation (FMT) in the eradication of antibiotic resistant bacteria, including those featuring of resistance to new generation…
- Trial name
- STOP-ARB2 (NCT06156956)
- Testing
- Fecal Microbiota Transplantation
- Where
- 5 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Human Biome S.A.
Irritable Bowel Syndrome
Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy
The aim of the current study is to test the hypothesis that patients with IBS may have a defective ICV pressures and may have small bowel bacterial overgrowth.
- Trial name
- NCT01413945
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Healthy
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
In this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to…
- Trial name
- NCT02847312
- Testing
- High avenanthramide, phenolic acid, Low avenanthramide, medium phenolic acid, Control
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
Uterine Prolapse, Urinary Incontinence
The Immune Reactivity of Biofilms in Vaginal Mesh Erosion.
Aging, birth trauma and extensive pelvic surgery are the causes known to cause advanced pelvic organ prolaspe, fecal as well as urinary incontinence.
- Conditions
- Uterine Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- NCT00564044
- Testing
- excision of the protruding mesh and its surrounding vaginal tissue
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Chang Gung Memorial Hospital
Diet, Healthy, Microbial Colonization
Networks of Bacterium-Metabolite Interactions in the Small Intestine
Probands with an Ileo- or Colostomy are assigned to consume a test meal which is either high in fat or high in carbohydrates. After the test meal samples from the stoma, urine, blood and skin are retrieved.
- Trial name
- NCT04978077
- Testing
- Test meal (high fat = Nutricia Calogen®, or high carbohydrate = Nutricia preOp®)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intestinal Bacteria Flora Disturbance
Use Babyguard® Breast Milk Probiotics to Verify the Authenticity of the Gut-Breast Axis Hypothesis
In order to understand the life history of the breast milk flora, explore its composition, source of strains, and ability to colonize the baby's intestinal environment, to find out strains with the potential of probiotics in…
- Trial name
- NCT04672889
- Testing
- Babyguard® Breast Milk Probiotics
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Metabolic Syndrome
Blackberry Flavonoid Absorption and Effects on Intestinal Bacteria
Intestinal bacteria can metabolize unabsorbed polyphenols (plant compounds) to produce smaller molecules which may impact health. In addition, evidence suggests that this process may be affected by body fatness.
- Trial name
- NCT01944579
- Testing
- Blackberries, Control
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Janet Novotny