Clinical trials: Gut Damage
Lymphomas, Solid Tumors
TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas
Background: Methoxyamine hydrochloride (TRC102) is a new cancer treatment drug that may help improve the results of chemotherapy.
- Conditions
- Lymphomas, Solid Tumors, NSCLC, Metastatic Colon Carcinoma
- Trial name
- NCT01851369
- Testing
- TRC102, CT scan, Lomotil
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Cancer Institute (NCI)
Frontal Lobe Dysfunction
Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage
High rates of patients with frontal brain damage show serious cognitive functional deficits, which negatively impact their quality of life and are linked with poor clinical outcomes.
- Trial name
- NCT04252261
- Testing
- sulforaphane, placedo
- Volunteers
- 90 people
- Sponsor
- Xiangya Hospital of Central South University
Urinary Tract Infections
Disturbance of the Intestinal Microbiota by Temocillin vs Cefotaxime in Treatment of Febrile Urinary Tract Infections
This study will evaluate the ecological impact on the intestinal microbiota and compare the safety and efficacy of temocillin compared to cefotaxime, in empiric treatment of febrile UTI.
- Trial name
- NCT02959957
- Testing
- Temocillin, Cefotaxime
- Where
- 12 sites in Sweden
- Volunteers
- 157 people
- Sponsor
- Håkan Hanberger
Intestinal Inflammation, Rhinosinusitis
the Prevalence of Chronic Rhinosinusitis Associated With Inflammatory Bowel Disease and Association With Biomarkers of Epithelial Barrier Damage
The goal of this observational study is to define the prevalence of chronic rhinosinusitis in patients with intestinal bowel disease.
- Trial name
- PRIME (NCT06149949)
- Testing
- Observational study
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Moisture Associated Skin Damage, Incontinence Associated Dermatitis
Testing the Safety and Efficacy of a Novel Barrier Cream for the Treatment of Moisture Associated Skin Damage
Liquid stool and diarrhea are associated with an increased risk for moisture-associated skin damage (MASD), and clinical evidence suggests that exposure to liquid stool is associated with severe MASD and extensive erosion of…
- Conditions
- Moisture Associated Skin Damage, Incontinence Associated Dermatitis, Fecal Incontinence
- Trial name
- NCT06221046
- Testing
- Control (Standard treatment), Novel Barrier Cream
- Volunteers
- 60 people
- Sponsor
- Scotiaderm
Solid Tumor, Clear Cell Renal Cell Carcinoma
Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors
This is a Phase 1b/2 study to determine the recommended phase 2 dose (RP2D), safety and tolerability, pharmacokinetics (PK) and clinical activity of the glutaminase inhibitor CB-839 with the poly adenosine diphosphate ribose…
- Conditions
- Solid Tumor, Clear Cell Renal Cell Carcinoma, TNBC - Triple-Negative Breast Cancer, Colorectal Cancer
- Trial name
- NCT03875313
- Testing
- CB-839, Talazoparib
- Where
- 9 sites in United States
- Volunteers
- 33 people
- Sponsor
- Calithera Biosciences, Inc
Crohn's Disease
The ImageKids Study: Developing the pMEDIC and the PICMI
The overall objectives of this study are to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in Pediatric Crohn's disease by means of Magnetic Resonance Imaging with…
- Trial name
- NCT01881490
- Testing
- MRE
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Shaare Zedek Medical Center
Cerebral Palsy, Congenital
Effects of Hippotherapy in Children With Cerebral Palsy
Cerebral palsy is a group of permanent disorders affecting movement and posture due to non-progressive disturbances in the developing brain.
- Trial name
- NCT07739680
- Testing
- Hippotherapy Program, Special Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fenerbahce University
Anal Sphincter Injury, Fecal Incontinence
Risk Factors for Anal Sphincter Damage During Vaginal Delivery
Vaginal delivery may cause various levels of damage to the anal sphincter. According to the literature, one third - two third of women diagnosed with 3rd degree rupture during vaginal delivery suffer from fecal incontinence.
- Trial name
- AnaSphRF (NCT01310426)
- Testing
- 3D transperineal Ultrasound
- Where
- Israel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cerebral Palsy
The Impact of Commercial Blenderized Formula on Caloric Needs, Gastrointestinal Symptoms, and Gut Microbiome in Children With Cerebral Palsy (CP)
The purpose of this study is to compare the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Scale Gastrointestinal Symptoms Scale (GI-PedsQL) differences , to assess the differences in stool microbiome and stool…
- Trial name
- NCT06488560
- Testing
- commercial blenderized tube feed (CBTF), commercial formulas (CF)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Moisture Associated Skin Damage, Fecal Incontinence
Testing a Novel Barrier Cream for Fecal Incontinence in an Ambulatory Population
Liquid stool and diarrhea are associated with an increased risk for moisture-associated skin damage (MASD), and clinical evidence suggests that exposure to liquid stool is associated with severe MASD and extensive erosion of…
- Conditions
- Moisture Associated Skin Damage, Fecal Incontinence, Incontinence Associated Dermatitis
- Trial name
- NCT06370637
- Testing
- Barrier Cream, Dermategrity Everyday Barrier Cream
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Scotiaderm
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Aortic Aneurysm, Gastrointestinal Dysfunction
Gastrointestinal Dysfunction in Aortic Surgery Patients
The goal of this observational study is to determine the association of gastrointestinal dysfunction through the Gastrointestinal Dysfunction Scale (GIDS) tool and serum concentrations of citrulline and Intestinal fatty-acid…
- Conditions
- Aortic Aneurysm, Gastrointestinal Dysfunction, Aortic Diseases, Enteral Feeding Intolerance
- Trial name
- NCT06514170
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 114 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Radiation Enteritis, Radiation Proctitis
Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet.
The study will consist of pair of double-blind placebo-controlled trials of dietary supplementation with 15g/day FructoOligoSaccharide (FOS) for 7.5 weeks in patients with prostate carcinoma or 5 weeks in patients with cervical…
- Trial name
- NCT01414517
- Testing
- FructoOligoSaccharide, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University College London Hospitals
IgA Nephropathy (IgAN)
Exploring the Brain - Gut Microbiota - Kidney Interactive Damage Mechanisms Underlying Cognitive Decline in Patients With IgA Nephropathy Using Ultra-high Field Magnetic Resonance Imaging
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Its progression is often accompanied by cognitive decline, manifesting as multi-dimensional cognitive deficits in areas such as memory, attention…
- Trial name
- NCT07617402
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Healthy
Effects of Ethanol on Intestinal Permeability and Integrity
Alcohol consumption is a major health problem worldwide. It affects all systems of the body especially the gastrointestinal tract.
- Trial name
- NCT00928733
- Testing
- Gastroduodenoscopy- Intraduodenal intubation
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Motor Weakness in Two or Four Limbs, Damage in the Anterior Spinal Artery (ASA)
Thrombolysis in Ischemic Spinal Cord Stroke
Ischemic stroke of the spinal cord is a rare disease accounting for about 1% of all ischemic events in the central nervous system (CNS).
- Conditions
- Motor Weakness in Two or Four Limbs, Damage in the Anterior Spinal Artery (ASA), Temperature and Superficial Sensation, Urinary Retention or Bowel Disorder
- Trial name
- NCT02242084
- Testing
- Intravenuse Alteplase
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Rabin Medical Center
Gastrointestinal, Hypoperfusion
Effects of Citrulline on Gut Functioning During Excercise
During exercise, splanchnic perfusion is compromised, resulting in organ damage in healthy individuals. Improving the availability of NO might result increase splanchnic perfusion and prevent organ damage during exercise.
- Conditions
- Gastrointestinal, Hypoperfusion, Gut Damage
- Trial name
- NCT01239303
- Testing
- Citrulline, alanine
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center