Clinical trials: Gut Function, active
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D)
Efficacy of Repeated Transcranial Magnetic Stimulation Combined With a Live Probiotic Tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live) in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
To evaluate the overall efficacy of repeated Transcranial Magnetic Stimulation(rTMS) combined with a Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live) in…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D), Repetitive Transcranial Magnetic Stimulation (rTMS), Probiotic
- Trial name
- NCT06960369
- Testing
- rTMS combined with Live Probiotic tablet
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University
Obesity / Overweight
Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients
This is an observational cohort study. The primary objective is to analyze the dynamic changes in gut microbiota and metabolic profiles in obese patients treated with Tirzepatide.
- Trial name
- NCT07847515
- Testing
- Tirzepatide
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 1 Diabetes
Intervention for Children With Type 1 Diabetes Targeting Gut Microbes
The goal of this clinical study is to evaluate the effect of nutritional intervention program based on dietary products in the clinical treatment of newly diagnosed children with type 1 diabetes.
- Trial name
- TRIM1 (NCT06198725)
- Testing
- Trimtab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Children's Hospital of Fudan University
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Irritable Bowel Disease
Relaxation Exercise and Education in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by chronic recurrent abdominal pain, bloating, changes in bowel habits or bowel movements (1-3).
- Trial name
- NCT06690762
- Testing
- Education
- Volunteers
- 100 people
- Sponsor
- Muş Alparslan University
Colorectal Cancer, Functional Status
Functional and Respiratory Predictors of Early Postoperative Outcomes
Functional status is a fundamental indicator reflecting a patient's ability to perform activities of daily living and is closely associated with early postoperative outcomes.
- Conditions
- Colorectal Cancer, Functional Status, Respiratory Parameters, Clinical Outcomes
- Trial name
- NCT07529301
- Testing
- Preoperative Assessments, Postoperative Assessments (Daily from Postoperative Day 1 Until Discharge)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Müşerref Ebru YALÇIN
Rectal Cancer
Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer
Background Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatments for patients with locally advanced rectal cancer.
- Trial name
- ARF-RC (NCT05671809)
- Testing
- NCRT with surgery, or NCT with surgery, or surgery
- Volunteers
- 402 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Irritable Bowel Syndrome
Study of Fecal Microbiota Transplantation (FMT) in Severe IBS Patients
The objective of this protocol is to evaluate the efficacy of fecal microbiota transplantation (FMT) using oral capsules containing frozen stools vs sham FMT on IBS severity score at 12 weeks in patients with severe irritable…
- Trial name
- ICEBOAT (NCT06433180)
- Testing
- Administration of fecal microbiota transplantation ( FMT capsules)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Functional Gastrointestinal Disorders
Exploring Novel Therapeutic Approaches for Disorders of Gut-Liver-Brain Interaction-H1/H2
Functional dyspepsia (FD) is associated with inflammatory responses caused by the release of histamine from eosinophils and mast cells, leading to increased intestinal mucosal permeability, which is a key pathogenic mechanism.
- Trial name
- NCT07857941
- Testing
- Famotidine, Levocetirizine, Fuyuan Gasmin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Irritable Bowel Syndrome (IBS)
Prospective Observational Study of Naturopathic Approaches to IBS
Irritable bowel syndrome (IBS) is a common condition affecting about 4% of people worldwide and can significantly impact quality of life and healthcare costs.
- Trial name
- NCT06721624
- Testing
- Naturopathic medicine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National University of Natural Medicine
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Irritable Bowel Syndrome
Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome
This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07467278
- Testing
- low fodmap diet, dietary intervention
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Colorectal Cancer, Respiratory Function
Functional and Respiratory Determinants of Long-Term Colorectal Cancer Outcomes
Colorectal cancer is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related morbidity and mortality.
- Conditions
- Colorectal Cancer, Respiratory Function, Functional Status, Long Term
- Trial name
- NCT07523919
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Inonu University
Pancreatic Cancer
Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma
NutriCa65-PDAC is a clinical study for patients aged 65 years or older with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
- Trial name
- NutriCa65-PDAC (NCT07821554)
- Testing
- Experimental: Personalised nutritional care delivered by a trained dietitian
- Where
- 5 sites in Denmark, Italy and 3 more
- Volunteers
- 250 people
- Sponsor
- Inna Chen, MD
IBS (Irritable Bowel Syndrome)
Transcranial Magnetic Stimulation and Pharmacologic/Probiotic Interventions for Diarrhea-Predominant IBS
What is the study about? This study is for adults with diarrhea-predominant irritable bowel syndrome (IBS-D) who suffer from chronic visceral pain.
- Trial name
- rTMS (NCT07172139)
- Testing
- Active rTMS + Pinaverium Bromide, Active rTMS + Bifidobacterium
- Volunteers
- 140 people
- Sponsor
- Rui Li
Cognition, Affect (Mental Function)
ETASCAN Project: ETAS Project 2
This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.
- Conditions
- Cognition, Affect (Mental Function), Sleep, MRI
- Trial name
- ETASCAN (NCT07550140)
- Testing
- ETAS®
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cystic Fibrosis (CF), CFTR-related Disorders
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
Sometimes it is very difficult to tell if someone has cystic fibrosis (CF), especially when they have rare CF genes. Without this certainty, they are unlikely to get the correct treatment so their health may be affected.
- Trial name
- ADVANCE-CFTR (NCT07402434)
- Testing
- Rectal Biopsy, Rectal biopsy taken opportunistically during endoscopy procedure for other reasons., Blood test for CFTR Genotyping
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause
Probiotic Intake and Perimenopausal Psychological Assessments
Recent evidence suggests multi-strain probiotics containing Lactobacillus rhamnosus and Bifidobacterium longum have been found to enhance emotional processing and reduce salience to negative cues in studies involving people with…
- Conditions
- Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations, Perimenopause, Perimenopause-Related Depression, Perimenopausal Women
- Trial name
- PIPPA (NCT07590999)
- Testing
- Multi-strain probiotic
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- University of Oxford