Clinical trials: Gut Metabolites
Anxiety, Microbiome
Microbiome, Anxiety and Cognitive Orientation Study
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood.
- Conditions
- Anxiety, Microbiome, Mood Disorders, Neurodegeneration
- Trial name
- MACO (NCT05388630)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Endominance
Multiple Sclerosis, Ulcerative Colitis
Determine PK Profiles of Ozanimod and Its' Major Metabolites in Healthy Subjects
The goal of this clinical trial is to learn how Ozanimod drug can be administered to the healthy subjects via transdermal delivery system (TDS, patch) to achieve better drug absorption and delivery than via oral capsules…
- Trial name
- NCT06528665
- Testing
- ZEPOSIA® indicated for the treatment of: Relapsing forms of multiple sclerosis, and active ulcerative colitis in adults
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Healthy Diet
Detection of Gut Metabolites in Mother's Milk Following Juice Intake
The goal of the biological sample collection is to assess the presence of gut metabolites in human breast milk (BM) samples obtained prospectively from healthy lactating mothers and after consumption of fruit juice.
- Trial name
- NCT04596254
- Testing
- Pomegranate Juice
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Healthy
Excretion of Radiolabelled AZD0837
This is an explorative study and the scientific question to be investigated in this study is if AZD0837 and/or its metabolites AR-H069927XX and AR-H067637XX and other unknown metabolites are excreted into the bile.
- Trial name
- NCT00812643
- Testing
- AZD0837
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
Effect of Proton Pump Inhibitors on Gut Microbiota Composition and Metabolites in Healthy Subjects Using CapScan
This study is designed to evaluate the effect of proton pump inhibitors on the regional composition of the gut microbiota and metabolic profiles of health volunteers using the CapScan collection capsule.
- Trial name
- NCT07054593
- Testing
- CapScan
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Envivo Bio Inc
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.
Healthy Individuals
Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals
Gut microbiota play a key role in polyphenol metabolism, participating in the breakdown of dietary components and producing various small molecule metabolites that affect human health.
- Trial name
- NCT07287306
- Testing
- BLa80, LRa05
- Where
- China
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Focus of the Study is on Gut Health
Effects of a Dietary Fiber on Fecal Microbiota and Metabolism
The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods.
- Trial name
- NCT01518088
- Testing
- Dietary Fiber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Changes in Gut Microbiota, Gut Metabolites, Respiratory Symptoms, and Well-being Index
A Probiotic for Health Outcomes in Short-Term Overseas Travel
With the improvement of living standards, travel has become a common form of leisure. However, travelers often face changes in living environments, dietary habits, and sleep schedules, all of which can impact the gut microbiota…
- Trial name
- NCT07705659
- Testing
- Bifidobacterium longum, Maltodextrin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DiproBio (Shanghai) Co., Ltd.