Clinical trials: Gut Metabolites
Chronic Kidney Disease Stage 3
Effects of Replacing High Protein Foods in People With Chronic Kidney Disease
The goal of this crossover clinical trial is to explore the effects of red meat intake on serum and fractional urinary excretion of uremic toxins including trimethylamine N-oxide in people with chronic kidney disease.
- Trial name
- NCT07105670
- Testing
- Controlled dietary intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
Gastrointestinal Dysfunction, Metabolic Disturbance
Hemp Fiber Ingestion and Gut Permeability After Exercise
Two bioactive compounds, N-trans-caffeoyl tyramine (NCT) and N-trans-feruloyl tyramine (NFT), have been investigated for potential gut health benefits. The shells of hemp seeds are a rich source of NCT and NFT.
- Trial name
- NCT06204666
- Testing
- High Dose Hemp Fiber Bar, Low Dose Hemp Fiber Bar
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Health Adults
The Effect of Increasing Dietary Protein on the Gut Microbiome and Its Metabolites
This study will determine the effect of dietary protein not absorbed in the small intestine on the bacteria in the large intestine and the metabolites those bacteria produce when they break down the protein.
- Trial name
- PSGM (NCT06677333)
- Testing
- Whey Protein, Pea protein
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Colorectal Cancer, Precancerous Polyp
A Study of a Urine Test to Detect Colorectal Cancer
The purpose of this study is to find out whether a urine test can detect colorectal cancer (CRC) and precancerous polyps in participants living in Ghana, Tanzania, and South Africa.
- Conditions
- Colorectal Cancer, Precancerous Polyp, Rectal Bleeding, CRC
- Trial name
- NCT07649057
- Testing
- 3-metabolite biosensor
- Where
- 4 sites in United States, Ghana and 2 more
- Volunteers
- 210 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study
The goal of this pilot intervention trial is to investigate the biological effects of daily supplementation with different doses of indole-3-propionic acid (IPA) in healthy adults.
- Trial name
- iPROACT-pilot (NCT06674018)
- Testing
- Indole-3-propionic acid
- Where
- Denmark
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Healthy
Pharmacokinetics and Bioavailability of Pomegranate Phenolics and Urolithins in Healthy Subjects.
Pomegranate phenolics (such as the ellagitannin punicalagin and ellagic acid) are metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A).
- Trial name
- POMEkinetics (NCT02056496)
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Sarcopenia, Older Adults
Distinct Exercise Modalities on Gut Microbiome
Sarcopenia is a multifactorial muscular disease with detrimental clinical consequences, impairing physical function, functional independence, quality of life, need for long-term care and premature mortality.
- Trial name
- DEMGUTS (NCT06545123)
- Testing
- Concurrent exercise training
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- Faculty of Sports- Research Center in Physical Activity, Health and Leisure
Obesity, Childhood
Pediatric Obesity Related Metabolite Profile and Gut Microbiota
In this study, the investigators aimed to observe changes in the gut microbial composition before and after the weight-loss intervention, including dietary control and exercise, in obese children.
- Trial name
- NCT03812497
- Testing
- Individualized Education Program
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Colorectal Cancer, Coffee
COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have completed routine treatment (including surgery…
- Conditions
- Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis
- Trial name
- COMMENCER (NCT05692024)
- Testing
- Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Cardiometabolic Health, Healthy Aging
Impacts of Fruit on the Gut Health and Human Health
The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.
- Conditions
- Cardiometabolic Health, Healthy Aging, Cognition
- Trial name
- NCT05063929
- Testing
- Fruit (2 cup eq), Fruit restriction (1/2 cup eq)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Hepatocellular Carcinoma
Prospective Cohort Study of Changes in Circulatory MicroRNA of Resected Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer death globally but only 20% are diagnosed in its early stages where curative treatment can be carried out.
- Trial name
- PROSECT (NCT05148572)
- Where
- 6 sites in Singapore
- Volunteers
- 101 people
- Sponsor
- National Cancer Centre, Singapore
Crohn's Disease
A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy
Phase IV Design : Prospective, open-label, randomized three-arms study Main Inclusion criteria Luminal Crohn's disease patients with steroid free remission for at least 6 months and a combination therapy with infliximab and…
- Trial name
- SPARE (NCT02177071)
- Testing
- INFLIXIMAB, AZATHIOPRINE, MERCAPTOPURINE
- Where
- 27 sites in Australia, Belgium and 1 more
- Volunteers
- 211 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Hemorrhagic Stroke, Acute
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage.
- Conditions
- Hemorrhagic Stroke, Acute, Outcomes, Metabolites
- Trial name
- NCT05551923
- Testing
- intestinal flora disturbance
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Diabetes-Related Complications
Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression
The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence.
- Trial name
- SBDD (NCT06979440)
- Testing
- No intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Nantong University
Irritable Bowel Syndrome
An Assessment of Cognitive Function in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common disorder affecting up to 20% of the general population. Despite the prevalence of the disorder, it remains poorly understood.
- Trial name
- NCT01304355
- Where
- 2 sites in Ireland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University College Cork
Hyperlipidemias
The Effect of n-3 PUFA Plant Oil Intake on Human Metabolism
The findings of previous experiments suggested that polyunsaturated fatty acids(PUFAs) has been linked to anti-hyperlipidemia, and reducing the risk of cardiovascular disease.This is a randomized double-blind trial, aims to study…
- Trial name
- PUFA (NCT03484988)
- Testing
- Echium oil, Mixed oil
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Huazhong University of Science and Technology
Ulcerative Colitis (UC)
Urinary PGE-MUM as a Marker for Ulcerative Colitis Activity
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that requires regular monitoring of disease activity. Currently, assessment depends on invasive colonoscopy or clinical scores that may not accurately reflect…
- Trial name
- PGE-MUM_UC (NCT07637045)
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Assiut University
Colorectal Adenoma
the Serum Metabolite Based PrecogColo Dx Test for Advanced Colorectal Neoplasia Screening
This study is to Evaluate the diagnostic sensitivity of the serum metabolite based PrecogColo Dx test for advanced colorectal neoplasia Screening, including advanced adenoma and colorectal cancer.
- Trial name
- NCT05870696
- Testing
- PrecogColo Dx test
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Peking University Third Hospital