Clinical trials: Gut Metabolites
Relapsing Remitting Multiple Sclerosis (RRMS)
Indole-3-PROpionic Acid Clinical Trials - Multiple Sclerosis
This study, iPROACT-MS, is part of the iPROACT group of clinical trials aiming to investigate the effects of oral supplementation with indole-3-propionic acid (IPA) in humans.
- Trial name
- iPROACT-MS (NCT07318129)
- Testing
- Indole-3-propionic acid (IPA)
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Diet, Healthy
The Impact of Dietary Protein on the Metabolome
It is known that tumors have an affinity for taking up amino acids from circulation or nearby tissues to use as a fuel source, to enhance their growth.
- Trial name
- NCT05377892
- Testing
- Dietary protein
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Constipation
The Colonic Transit Time: a Modifiable Determinant of Intestinal Production and Uptake of Microbial Metabolites?
Chronic kidney disease is associated with the accumulation of various metabolites, i.e., uremic retention solutes. Evidence is mounting that the colonic microbiome contributes substantially to these uremic retention solutes.
- Trial name
- NCT01869751
- Testing
- Prucalopride
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Calcific Aortic Valve Disease, Inflammation
Impact of TAVI on the Gut Microbiota and Its Metabolites
Aortic stenosis is a common heart valve disease in older adults. It occurs when the aortic valve becomes narrowed, making it harder for blood to flow from the heart to the rest of the body.
- Conditions
- Calcific Aortic Valve Disease, Inflammation, Dysbiosis, TAVI
- Trial name
- Swiss-GUT-TAVI (NCT07565077)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Lifestyle
Protein-Distinct Macronutrient-Equivalent Diet 1
Plant-based diets are naturally low in Methionine (Met), and also low in precursor molecules (e.g L-carnitine, choline, betaine, etc.) producing microbiota-mediated proatherogenic TMAO.
- Trial name
- PRODMED1 (NCT05577858)
- Testing
- Meat based, Pulse based
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Colonic Cancer
Aquamin and Prevention of Colon Cancer
In the proposed study, investigators will conduct a 90-day dietary intervention study in human subjects. Thirty individuals at risk for adenomatous colon polyp formation will be randomized to receive a calcium and…
- Trial name
- NCT02647671
- Testing
- Aquamin®, Calcium Carbonate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- James Varani
Cancer, Glioma
Symptom Cluster Heterogeneity and Gut Microbiota Mechanisms in Childhood Cancer Survivors
Advances in medical care have significantly improved survival among children with cancer. In China, the 5-year survival rate has reached 71.9%.
- Conditions
- Cancer, Glioma, Leukemia (Both ALL and AML)
- Trial name
- SC-Het-GM-CCS (NCT07450872)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Chronic Kidney Disease
Intestinal Transport of Microbial Metabolites in Chronic Kidney Disease
Chronic kidney disease is associated with the accumulation of various metabolites, i.e., uremic retention solutes. Evidence is mounting that the colonic microbiome contributes substantially to these uremic retention solutes.
- Trial name
- NCT01752738
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity, Mild Cognitive Impairment
Improvement of Fish Oil in Obesity With Mild Cognitive Impairment
Eighty-eight patients with obesity with mild cognitive impairment（MCI） from the Multicenter Nutrition and Chronic Disease Cohort, who met the inclusion and exclusion criteria, were selected as study subjects and randomly divided…
- Trial name
- NCT06992726
- Testing
- Fish oil intervention
- Volunteers
- 88 people
- Sponsor
- Weiwei Ma
Colorectal Cancer
Pomegranate Extract Supplementation in Colorectal Cancer Patients
The most relevant pomegranate phenolics (ellagitannins and ellagic acid) are extensively metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A).
- Trial name
- POMEcolon (NCT01916239)
- Testing
- Standard pomegranate extract formulation, Pomegranate extract formulation-1, Pomegranate extract formulation-2
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Breast Cancer, Colorectal Cancer
Association of Capecitabine Pharmacokinetics and Toxicity With Aging
This is a multi-centre prospective non-interventional study designed to evaluate the effects of patient age on the pharmacokinetics of capecitabine and its metabolites 5'DFCR, 5'DFUR, and 5-FU.
- Trial name
- NCT03465202
- Testing
- Capecitabine
- Volunteers
- 100 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Healthy
Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults.
- Trial name
- iPROACT-pilot2 (NCT07105514)
- Testing
- Indole-3-propionic acid (IPA)
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Colorectal Cancer, Diet Habit
Walnuts and Colon Health (The WellNut Trial)
The purpose of this research study is to examine whether adding walnuts to your diet can have a beneficial effect on the gut bacteria population, inflammatory markers in the blood, and the tissue that lines the inside of the…
- Trial name
- NCT05195970
- Testing
- Walnuts
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- UConn Health
Type 2 Diabetes Mellitus, Coronary Heart Disease
Glycemic Variability, Gut Microbiota, and Prognosis in T2DM With ACS
Patients with type 2 diabetes mellitus (T2DM) diagnosed with acute coronary syndrome (ACS) by coronary angiography in the Second Affiliated Hospital of Nanchang University were consecutively included in a prospective cohort…
- Trial name
- NCT06573060
- Testing
- Continuous glucose monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Healthy Diet
Detection of Gut Metabolites in Mother's Milk Following Juice Intake
The goal of the biological sample collection is to assess the presence of gut metabolites in human breast milk (BM) samples obtained prospectively from healthy lactating mothers and after consumption of fruit juice.
- Trial name
- NCT04596254
- Testing
- Pomegranate Juice
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Crohn's Disease
Urinary Prostaglandin E Metabolite (PGE-M), A Metabolite of Prostaglandin E2 (PGE2): A Novel Biomarker of Crohn's Disease Activity
The purpose of this study is to determine whether urinary PGE-M levels correlate with Crohn's disease activity and to compare how well urinary PGE-M correlates with other non-invasive biomarkers of disease activity such as…
- Trial name
- NCT00496548
- Testing
- Fecal calprotectin, Urinary PGE-M Level
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Vanderbilt University Medical Center
Healthy
Excretion of Radiolabelled AZD0837
This is an explorative study and the scientific question to be investigated in this study is if AZD0837 and/or its metabolites AR-H069927XX and AR-H067637XX and other unknown metabolites are excreted into the bile.
- Trial name
- NCT00812643
- Testing
- AZD0837
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Non-Alcoholic Fatty Liver Disease, Obesity
Effects of Dietary Fructose on Gut Microbiota and Fecal Metabolites in Obese Men and Postmenopausal Women: A Pilot Study
Non alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal liver function tests in the U.S. (Browning, et al., 2004), ranging from steatosis to end-stage liver disease.
- Trial name
- NCT03339245
- Testing
- Fructose Solution (75 Grams), Glucose Solution (75 grams)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Diabetic Kidney Disease
Gut Microbiota and Serum Metabolites as Predictors of Glycemic Variability and Outcomes in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is one of the main complications of diabetes and a leading cause of end-stage kidney disease. Blood glucose variability is closely associated with disease progression in individuals with DKD.
- Trial name
- NCT07352436
- Volunteers
- 270 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
Vitamin E Supplements in Treating Patients Undergoing Surgery for Colorectal Cancer
RATIONALE: Vitamin E may help prevent the development of cancer. Studying samples of tissue from patients with colorectal cancer who receive Vitamin E before undergoing surgery in the laboratory may help doctors learn more about…
- Trial name
- NCT00905918
- Testing
- vitamin E, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rutgers, The State University of New Jersey