Clinical trials: Gut Metabolites
Inflammation, Metabolic Disorder
Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes.
- Conditions
- Inflammation, Metabolic Disorder, Hypertriglyceridemia
- Trial name
- NCT05255718
- Testing
- Aronia juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montana State University
Crohn's Disease, Ulcerative Colitis
The Influence of 5-Aminosalicylates on Thiopurine Metabolite Levels
The purpose of this study is to determine the influence of different 5-aminosalicylate concentrations on the metabolism of azathioprine or 6-mercaptopurine in patients with inflammatory bowel disease.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT00167882
- Testing
- 5-aminosalicylate (Pentasa, Ferring)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Amsterdam UMC, location VUmc
Microbiome, Human
Effects of IAP-EOGBSD on Maternal Vaginal Microbiome, Offspring's Gut Microbiome and Metabolites.
In view of the current status of prevention and research on GBS disease in mothers and infants at home and abroad, this project intends to explore the characteristics of vaginal microbiota of GBS-colonized pregnant women in…
- Trial name
- NCT05738473
- Testing
- antibiotic
- Where
- China
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Gut Microbiota Dysbiosis and Nutrition
Inulin and the Gut Microbiota in Healthy Adults
In this study the effects of a fibre dietary supplement on the gut microbiome in healthy adults will be investigated. For this purpose, a 14-day dietary supplementation with inulin or placebo (maltodextrin) will be carried out in…
- Trial name
- INLITE (NCT05399316)
- Testing
- Inulin, Maltodextrin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Experimental and Clinical Research Center
Diet Modification
Metabotypes in the Urinary Excretion of Flavan-3-ol Metabolites: "Metanols"
Flavan-3-ols are the main source of flavonoids in Western diets. They are characteristic compounds of tea, cocoa, wine, apple, pears, etc.
- Trial name
- Metanols (NCT04124016)
- Testing
- Inulin, green tea extract, grape seed
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Parma
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers
Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents
Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as…
- Conditions
- Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
- Trial name
- NCT07125001
- Testing
- Ataulfo mango
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Amyotrophic Lateral Sclerosis
Correlation Between Intestinal Microflora Metabolites and Amyotrophic Lateral Sclerosis
To verify the correlation between TMAO level and the pathogenesis and progression of ALS
- Trial name
- NCT04948346
- Testing
- diagnosed with ALS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Microbiota
Gut Microbiota in Chronic GI Diseases
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease.
- Trial name
- ChronicGI (NCT06532110)
- Testing
- Endoscopy/Colonoscopy
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- McMaster University
Metabolic Disturbance, Permeability; Increased
Betaine, Exercise Performance, and Gut Permeability
This study will determine if ingestion of 3 g/d betaine versus placebo for two weeks prior to a 60-km cycling time trial will improve performance, moderate exercise-induced gut permeability, and improve metabolic recovery.
- Trial name
- NCT06392360
- Testing
- Betaine
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Appalachian State University
Liver Disease; Alcohol-Related, Gut Microbiota
Alterations of Gut Microbiota and Metabolites in ALD Patients
Alcohol-associated liver disease is one of the most prevalent liver diseases worldwide, and the leading cause of liver transplantation in the U.S.
- Trial name
- NCT05448144
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy, Controlled Feeding Trial
Gut Microbial Metabolites of Apple Polyphenols
The goal of this controlled feeding trial is to learn about the metabolism of polyphenols, a common class of compounds found in plant-based foods, by the gut microbiome.
- Trial name
- GutMMAP (NCT06107192)
- Testing
- Dietary intervention - apple catechin diet, Dietary intervention - low catechin diet
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Sarcopenia, Dietary Exposure
Impact of Diet on the Gut-Muscle Axis in Older Adults
Muscle health declines during aging. One factor that may impact muscle health is the community of bacteria that live in our intestines, but studies aimed at improving muscle health by targeting the gut in older adults are sparse.
- Conditions
- Sarcopenia, Dietary Exposure, Microbial Colonization
- Trial name
- NCT05549622
- Testing
- Low-soluble fiber diet, High-soluble fiber diet
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tufts University
Chronic Kidney Disease
AXOS and Microbial Metabolites in CKD
Chronic kidney disease is associated with the accumulation of various metabolites, i.e., uremic retention solutes. Evidence is mounting that the colonic microbiota contributes substantially to these uremic retention solutes.
- Trial name
- NCT02141815
- Testing
- Arabinoxylan-oligosaccharides, Maltodextrine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulcerative Colitis
A Study to Determine Whether Urinary PGE-M Levels Correlate With Ulcerative Colitis Disease
The purpose of this study is to determine whether urinary PGE-M levels correlate with Ulcerative Colitis Disease activity and to compare how well urinary PGEm correlates with other noninvasive biomarkers of disease activity such…
- Trial name
- NCT00409396
- Testing
- Urinary PGEm level, fecal calprotectin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Vanderbilt University
Chronic Kidney Diseases
Impact of Gum Acacia on Chronic Kidney Disease Patients
The aim of the study is to evaluate the impact of gum acacia on serum levels of protein-bound uremic toxins (indoxyl sulfate and p-cresyl sulfate).In addition to the evaluation of its effect on metabolic profile and disease…
- Trial name
- NCT05599399
- Testing
- Gum acacia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Head and Neck Cancer (H&N)
Fecal Microbiota And Metabolites In Head And Neck Cancer Patients Receiving (Chemo)Radiotherapy
This clinical study investigates whether the composition of the fecal microbiome and selected bacterial metabolites are associated with the efficacy and acute toxicity of radiotherapy in patients with locally advanced head and…
- Trial name
- NCT07407218
- Testing
- Radical (Chemo)Radiotherapy
- Where
- Slovenia
- Volunteers
- 58 people
- Sponsor
- Institute of Oncology Ljubljana
Health
Effects of Coffee Consumption on Health Among Adults
The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard…
- Trial name
- NCT03817944
- Testing
- Warm Water, Caffeinated Coffee, Decaffeinated Coffee
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Attention-deficit/Hyperactivity Disorder
Gut Microbiome and Serum Metabolome Alterations in ADHD Patients
Host-microbe interactions play a key role in brain development and function and in the etiology of neurodevelopmental disorders.
- Trial name
- ADHD (NCT03447223)
- Where
- China
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Healthy Subjects
Effect of Proton Pump Inhibitors on Gut Microbiota Composition and Metabolites in Healthy Subjects Using CapScan
This study is designed to evaluate the effect of proton pump inhibitors on the regional composition of the gut microbiota and metabolic profiles of health volunteers using the CapScan collection capsule.
- Trial name
- NCT07054593
- Testing
- CapScan
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Envivo Bio Inc
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.