Clinical trials: Gut Metabolites
Metabolites, Gut Microbiota
Interindividual Variation in Excretion of Curcumin
The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.
- Trial name
- NCT03746158
- Testing
- curcumin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Frontal Lobe Dysfunction
Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage
High rates of patients with frontal brain damage show serious cognitive functional deficits, which negatively impact their quality of life and are linked with poor clinical outcomes.
- Trial name
- NCT04252261
- Testing
- sulforaphane, placedo
- Volunteers
- 90 people
- Sponsor
- Xiangya Hospital of Central South University
Depressive Symptoms
Berries, Bugs, and the Blues
This study aims to investigate the impact of daily freeze-dried blueberry powder consumption on the gut microbiota, fecal short chain fatty acids, and depressive symptom severity in 40older, sedentary adults with depressive…
- Trial name
- NCT05817383
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hebrew SeniorLife
Inflammation Gastrointestinal Tract
Identifying the Microbial Metabolome: The Missing Link Between Diet and Human Health
There is a lot of evidence to suggest that the bacteria in our gut play a major role in maintaining our health, but very little is known about the way in which this is achieved.
- Trial name
- NCT07591961
- Testing
- Food
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Fibromyalgia (FM)
Dietary Strategies for the Treatment of Fibromyalgia in Overweight and Obese Patients
Spontaneous, non-sponsored, interventional, controlled, randomized, parallel-arm clinical study. Primary objective To assess the impact of specific dietary approaches (ketogenic diet, Mediterranean diet, or Mediterranean diet…
- Trial name
- FIBRODIET (NCT07517757)
- Testing
- Very Low-Calorie Ketogenic Diet, Mediterranean diet, Mediterranean diet enriched by GABA-producing probiotic
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Universita degli Studi di Genova
Sarcopenia, Inflammation
Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly
Sarcopenia, which refers to the progressive loss of skeletal muscle mass and strength, shares many characteristics with other disease states typically associated with risks of falling and fracture, including osteoporosis…
- Conditions
- Sarcopenia, Inflammation, Aging
- Trial name
- NCT04985877
- Testing
- Yakult 300 LIGHT Fermented Milk
- Where
- 3 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Nonalcoholic Fatty Liver Disease - Intermittent Calorie Restriction (FLICR) Study
Several diets have been proposed to reduce liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD), and various effects on liver steatosis have been observed.
- Trial name
- NCT05309642
- Testing
- Intermittent calorie restriction, Standard of care
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Gestational Diabetes Mellitus (GDM), Blood Glucose
Diabetes, Insulin, Gut, Enteric Supplementation Trial
Pregnancy is a critical window for metabolic health, and early changes in blood sugar regulation can increase the risk of gestational diabetes mellitus (GDM), which affects both maternal and infant health.
- Conditions
- Gestational Diabetes Mellitus (GDM), Blood Glucose, Insulin Resistance, Diabetes, Gut Microbiome
- Trial name
- DIGEST (NCT07682077)
- Testing
- Kefir
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Allergic Disorder, Food Hypersensitivity
Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age…
- Conditions
- Allergic Disorder, Food Hypersensitivity, Food Allergy in Children
- Trial name
- NCT05442658
- Testing
- Microbiota
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Menstrual Cycle, Athletes
Identifying Periods of High Training Load Considering the Menstrual Cycle Phases in Elite and Non-elite Female Athletes
Despite a rise in the number of women participating in competitive sports, there remains a gender gap within sport and exercise science literature.
- Conditions
- Menstrual Cycle, Athletes, Physical Activity
- Trial name
- NCT06377306
- Testing
- Effect of training loads and sport performance level on health and sport performance
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wingate Institute
Irritable Bowel Syndrome, Microbial Colonization
Microbiota Profiling in IBS
This study investigates differences in microbiota profiles and metabolite levels between mild and severe IBS patients, compared to matched healthy controls. Two fecal samples, with one month in between, will be analyzed.
- Conditions
- Irritable Bowel Syndrome, Microbial Colonization, Dietary Habits
- Trial name
- IBSQUtrition (NCT03720314)
- Testing
- NA observational study
- Where
- Netherlands
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Acute Pancreatitis, 2019 Novel Coronavirus Infection
Study and Analysis of Acute Pancreatitis Complicated With COVID-19
The goal of this observational study was to explore the complex relationship between changes in the intestinal microbiome and serum metabolites in patients with novel coronavirus infection and acute pancreatitis.
- Trial name
- NCT05722678
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yuansong Sun
Microbiota
Gut Microbiota and Nonpuerperal Mastitis
Nonpuerperal mastitis (NPM), mainly including Plasma cell mastitis (PCM) and Granulomatous mastitis (GM), which clinical presentation is an accessible and painful breast mass accompanied by skin redness and swelling, nipple…
- Trial name
- NCT05051215
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Chronic Obstructive Pulmonary Disease
Characteristics of Intestinal Microbiome in the Progression of Early COPD
This study is aiming at explore the characteristics of intestinal microbiome during the early progression of COPD, the correlation between the changes of intestinal microbiome and the severity and risk of acute exacerbation of…
- Trial name
- NCT04876833
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Pelvic Neoplasm
Exploiting the Gut Microbiota and Its Metabolites in Pelvic Cancer
The large intestine is the last part of the digestive tract. It absorbs water and dietary substances. However, it is also where most of our bacteria are resident.
- Trial name
- NCT05605353
- Testing
- Faecal microbiota sampling and blood sampling
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- University of Aberdeen
Irritable Bowel Syndrome
Analysis of Differences in Small Intestinal Microbiota Structure and Metabolites Between Patients With Irritable Bowel Syndrome and Healthy Individuals
Irritable Bowel Syndrome (IBS) is a common functional bowel disorder with complex and not yet fully elucidated pathophysiological mechanisms.
- Trial name
- NCT07212569
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Diet, Healthy, Microbial Colonization
Networks of Bacterium-Metabolite Interactions in the Small Intestine
Probands with an Ileo- or Colostomy are assigned to consume a test meal which is either high in fat or high in carbohydrates. After the test meal samples from the stoma, urine, blood and skin are retrieved.
- Trial name
- NCT04978077
- Testing
- Test meal (high fat = Nutricia Calogen®, or high carbohydrate = Nutricia preOp®)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Inflammatory Bowel Diseases
Biobank - Investigating the Gut Microbiota, Genetics, Epigenetics and Metabolites
Inflammatory bowel disease (IBD) affects 1 in 500 to 1,000 people in the West. Previously a disease predominantly of the West, there is now a marked increase in the incidence of ulcerative colitis (UC) and Crohn's disease (CD) in…
- Trial name
- NCT03855657
- Where
- Hong Kong
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Insulin Resistance
Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance
The primary aims of the current study: using L-carnitine supplementation modulate the level of plasma trimethylamine N-oxide to assess its effect on circulating cytokines related to diabetes and metabolic syndrome; using…
- Trial name
- MR (NCT05251207)
- Testing
- L-carnitine, L-leucine, Change of the circadian cycle
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education